Karin Nielsen

Production of no-carrier-added holmium-166 by double neutron capture reaction at McMaster University research reactor

Karin Nielsen, Derek R. Morim, Karin A. Stephenson, Harshaben Sindhi et autres

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Optimization of technetium-94m production by cyclotron proton-irradiation of phosphomolybdic acid in automated liquid target system

Chloe Green, T. Gregory P. Harper, Dhyey Mehta, Jordan Cale et autres

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Adverse fetal and perinatal outcomes associated with Zika virus infection during pregnancy: an individual participant data meta-analysis

Edna Acosta‐Pérez, Juan Aguilar Ticona, Jackeline Alger, Emily Ansusinha et autres

Background: Zika virus (ZIKV) infection during pregnancy is associated with an increased risk of congenital malformations. The prevalence of short and long-term consequences, however, remains uncertain due to heterogeneity across studies. Individual Participant Data Meta-Analysis (IPD-MA) offers an alternative approach to provide …

Strategies to Facilitate Service Utilization Among Youth at Risk for HIV: A Randomized Controlled Trial (ATN 149)

Dallas T. Swendeman, Mary Jane Rotheram‐Borus, Elizabeth Mayfield Arnold, María Isabel Ruiz Fernández et autres

Sexual and gender minority youth (SGMY) are vulnerable to acquiring HIV and need HIV prevention and health services, but may have competing needs. A prior analysis found that PrEP use reports increased in a combination intervention study arm with coaching, peer support, …

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Effectiveness of the Original Monovalent Messenger RNA Coronavirus Disease 2019 (COVID-19) Vaccination Series Against Hospitalization for COVID-19–Associated Venous Thromboembolism

David N. Hager, Yuwei Zhu, Ine Sohn, William B. Stubblefield et autres

BACKGROUND: Coronavirus disease 2019 (COVID-19) is a strong risk factor for venous thromboembolism (VTE). Few studies have evaluated the effectiveness of COVID-19 vaccination in preventing hospitalization for COVID-19 with VTE. METHODS: Adults hospitalized at 21 sites between March 2021 and October 2022 …

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Optimised production of technetium-94m for PET imaging by proton-irradiation of phosphomolybdic acid in cyclotron liquid target

R. K. Harper, Derek R. Morim, Dhyey Mehta, Veronika Rosecker et autres

Natural-abundance phosphomolybdic acid (H3(Mo12PO40) ‧12H2O, 0.181-0.552 g Mo/mL) solutions were irradiated with 12.9 MeV protons on a GE PETtrace cyclotron using an adapted standard liquid target. Technetium-94m (94mTc) was produced through the 94Mo(p,n)94mTc nuclear reaction with saturation yields of up to 53 …

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Optimal strategies to improve uptake of and adherence to HIV prevention among young people at risk for HIV acquisition in the USA (ATN 149): a randomised, controlled, factorial trial

Dallas T. Swendeman, Mary Jane Rotheram‐Borus, Elizabeth Mayfield Arnold, Maria Isabel Fernandez et autres

BACKGROUND: Pre-exposure prophylaxis (PrEP), condom use, post-exposure prophylaxis (PEP), and sexual partner reduction help to prevent HIV acquisition but have low uptake among young people. We aimed to assess the efficacy of automated text messaging and monitoring, online peer support, and strengths-based …

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Optimised Production of Technetium-94m for Pet Imaging by Proton-Irradiation of Phosphomolybdic Acid in Cyclotron Liquid Target

R. K. Harper, Derek R. Morim, Dhyey Mehta, Veronika Rosecker et autres

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Implementation and optimisation of scandium-44 and manganese-52 production at King’s College London for preclinical research

Karin Nielsen, Veronika Rosecker, Esra Korpe, David A.S Parker et autres

Using Machine Learning to Identify Predictors of Sexually Transmitted Infections Over Time Among Young People Living With or at Risk for HIV Who Participated in ATN Protocols 147, 148, and 149

Warren Scott Comulada, Mary Jane Rotheram‐Borus, Elizabeth Mayfield Arnold, Peter Norwood et autres

BACKGROUND: Sexually transmitted infections (STIs) among youth aged 12 to 24 years have doubled in the last 13 years, accounting for 50% of STIs nationally. We need to identify predictors of STI among youth in urban HIV epicenters. METHODS: Sexual and gender …

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Changing Severity and Epidemiology of Adults Hospitalized With Coronavirus Disease 2019 (COVID-19) in the United States After Introduction of COVID-19 Vaccines, March 2021–August 2022

Noah Kojima, Katherine Adams, Wesley H. Self, Manjusha Gaglani et autres

INTRODUCTION: Understanding the changing epidemiology of adults hospitalized with coronavirus disease 2019 (COVID-19) informs research priorities and public health policies. METHODS: Among adults (≥18 years) hospitalized with laboratory-confirmed, acute COVID-19 between 11 March 2021, and 31 August 2022 at 21 hospitals in …

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Microwave-assisted synthesis of [52Mn]Mn-porphyrins: Applications in cell and liposome radiolabelling

Peter J. Gawne, Sara M. A. Pinto, Karin Nielsen, George P. Keeling et autres

Manganese porphyrins have several therapeutic/imaging applications, including their use as radioprotectants (in clinical trials) and as paramagnetic MRI contrast agents. The affinity of porphyrins for lipid bilayers also makes them candidates for cell/liposome labelling. We hypothesised that metalation with the positron emission …

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