Jennifer M. MacDonald

Noninvasive Neuromonitoring Modalities in Children Part I: Pupillometry, Near-Infrared Spectroscopy, and Transcranial Doppler Ultrasonography

Marlina E. Lovett, Jennifer M. MacDonald, Marina Villalón Mir, Suman Ghosh et autres

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Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling

Tsai-Yi Lu, Jennifer M. MacDonald, Lukas J. Neukomm, Amy E. Sheehan et autres

Draper/Ced-1/MEGF-10 is an engulfment receptor that promotes clearance of cellular debris in C. elegans, Drosophila and mammals. Draper signals through an evolutionarily conserved Src family kinase cascade to drive cytoskeletal rearrangements and target engulfment through Rac1. Glia also alter gene expression patterns …

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dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

Jeannette M. Osterloh, Jing Yang, Timothy M. Rooney, A. Nicole Fox et autres

Axonal and synaptic degeneration is a hallmark of peripheral neuropathy, brain injury, and neurodegenerative disease. Axonal degeneration has been proposed to be mediated by an active autodestruction program, akin to apoptotic cell death; however, loss-of-function mutations capable of potently blocking axon self-destruction …

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A Role for c-Jun Kinase (JNK) Signaling in Glial Engulfment of Degenerating Axons: A Dissertation

Jennifer M. MacDonald

The central nervous system (CNS) is composed of two types of cells: neurons that send electrical signals to transmit information throughout the animal and glial cells. Glial cells were long thought to be merely support cells for the neurons; however, recent work …

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The Drosophila Cell Corpse Engulfment Receptor Draper Mediates Glial Clearance of Severed Axons

Jennifer M. MacDonald, Margaret G. Beach, Ermelinda Porpiglia, Amy E. Sheehan et autres

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