Accès ouvert
2026
preprint
OpenAlex
Mackenzie Welch, Paul J. Sampognaro, Shunpan Shu, Kriti Chaplot et autres
Abstract Lysosomes make key contributions to the maintenance of cellular proteostasis, and their functional compromise has been linked to aging and neurodegenerative disease. A defining characteristic of lysosomes is their relative acidity compared to other subcellular compartments, a quality that enables the …
us, gb
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Lovleen Garg, Kriti Chaplot, Gowhith Kuppili, Shweta Tendulkar et autres
Abstract Membrane Contact sites (MCS) have emerged as physiologically relevant zones that coordinate inter-organelle communication and cellular function. VAPB, an ER-resident MCS tethering protein, plays a central role in regulating MCSs through its numerous protein interactors, thereby influencing cellular homeostasis. A pathogenic …
in
(code pays fourni par la source)
Accès ouvert
2026
dataset
OpenAlex
Lovleen Garg, Kriti Chaplot, Gowhith Kuppili, Shweta Tendulkar et autres
Supplementary Material 2
in
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Lovleen Garg, Kriti Chaplot, Gowhith Kuppili, Shweta Tendulkar et autres
Supplementary Material 1
in
(code pays fourni par la source)
Accès ouvert
2026
dataset
OpenAlex
Lovleen Garg, Kriti Chaplot, Gowhith Kuppili, Shweta Tendulkar et autres
Supplementary Material 2
in
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Lovleen Garg, Kriti Chaplot, Gowhith Kuppili, Shweta Tendulkar et autres
Supplementary Material 1
in
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Lovleen Garg, Kriti Chaplot, Gowhith Kuppili, Shweta Tendulkar et autres
Abstract Membrane Contact sites (MCS) have emerged as physiologically relevant zones that coordinate inter-organelle communication and cellular function. VAPB, an ER-resident MCS tethering protein, plays a central role in regulating MCSs through its numerous protein interactors, thereby influencing cellular homeostasis. A pathogenic …
in
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Kriti Chaplot, Lin Zhang, Julia Wessman, Miguel Rivera et autres
Summary In vitro modelling of highly vulnerable nigral dopaminergic (DA) neuronal subtypes in Parkinson’s disease (PD), is necessary for studying disease mechanisms. Here, we optimized a new approach by expressing the pioneer neurogenic transcription factor, Achaete-scute-like 1 ( Ascl1 ), implicated in …
us
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Juan R. Peinado, Kriti Chaplot, Timothy S. Jarvela, Edward M. Barbieri et autres
As neurons age, protein homeostasis becomes less efficient, resulting in misfolding and aggregation. Chaperone proteins perform vital functions in the maintenance of cellular proteostasis, and chaperone-based therapies that promote sequestration of toxic aggregates may prove useful in blocking the development of neurodegenerative …
us
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Timothy S. Jarvela, Kriti Chaplot, Iris Lindberg
Alpha-synuclein pre-formed fibrils (PFFs) represent a promising model system for the study of cellular processes underlying cell-to-cell transmission of alpha-synuclein proteopathic aggregates. However, the ability to differentiate the fate of internalized PFFs from those which remain in the extracellular environment remains limited …
us
(code pays fourni par la source)
Accès ouvert
2020
preprint
OpenAlex
Timothy S. Jarvela, Kriti Chaplot, Iris Lindberg
ABSTRACT Alpha-synuclein pre-formed fibrils (PFFs) represent a promising model system for the study of cellular processes underlying cell-to-cell transmission of alpha-synuclein proteopathic aggregates. However, the ability to differentiate the fate of internalized PFFs from those which remain in the extracellular environment remains …
us
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Kriti Chaplot, Timothy S. Jarvela, Iris Lindberg
Protein homeostasis, or proteostasis, is a combination of cellular processes that govern protein quality control, namely, protein translation, folding, processing, and degradation. Disruptions in these processes can lead to protein misfolding and aggregation. Proteostatic disruption can lead to cellular changes such as …
us
(code pays fourni par la source)