Samir Bidnur

ATM Immunohistochemistry as a Tool to Identify and Classify Somatic ATM Variants in Prostate Cancer

Roger Ferreira, Kassandra R. Bisson, Andrea Beharry, C. J. Nicholas et autres

Background/Objectives: Ataxia telangiectasia-mutated kinase is encoded by the ATM gene. This gene is altered in many cancer types; however, it is most relevant for eligibility of poly-ADP-ribose polymerase inhibitor (PARPi) therapy in metastatic castrate-resistant prostate cancer in Canada. Non-benign ATM alterations are …

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Mediators of human ureteral smooth muscle contraction—a role for erythropoietin, tamsulosin and Gli effectors

Kymora B. Scotland, Samir Bidnur, Lu Wang, Ben H. Chew et autres

BACKGROUND: Ureteral contractility is a poorly understood process. Contractions have been demonstrated to occur in the smooth muscle layers of the ureter. Previous work suggests the involvement of Gli family proteins and erythropoietin (EPO) in regulating mammalian ureteral smooth muscle contraction. We …

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A polymeric paste-drug formulation for local treatment of upper tract urothelial carcinoma

Claudia Kesch, Veronika Schmitt, Samir Bidnur, Marisa Thi et autres

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Design and Characterization of Injectable Poly(Lactic-Co-Glycolic Acid) Pastes for Sustained and Local Drug Release

Veronika Schmitt, Claudia Kesch, John K. Jackson, Samir Bidnur et autres

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A polymeric paste-drug formulation for intratumoral treatment of prostate cancer

Claudia Kesch, Veronika Schmitt, Samir Bidnur, Marisa Thi et autres

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Does intra‐operative verapamil administration in kidney transplantation improve graft function

Nidhi Gupta, Mauricio Caldas, Nitin Sharma, Samir Bidnur et autres

The role of the calcium channel blocker (verapamil) in kidney transplant is controversial. Verapamil has been hypothesized to mitigate ischemia reperfusion injury (IRI) to the allograft. Herein, we evaluated the effect of intra-operative verapamil administration in a large cohort of kidney transplants. …

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PEG10 is associated with treatment-induced neuroendocrine prostate cancer

Soojin Kim, Daksh Thaper, Samir Bidnur, Paul Toren et autres

Neuroendocrine (NE) differentiation of advanced prostate adenocarcinoma following androgen receptor (AR) axis-directed therapy is becoming increasingly recognized. Several models of this transdifferentiation provide insight into its molecular pathogenesis and have highlighted the placental gene PEG10 for further study. Using our unique model …

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Renal transplant anastomotic pseudoaneurysms: Case report of open repair and endovascular management

Nitin Sharma, Samir Bidnur, Mauricio Caldas, Dermot McNally et autres

INTRODUCTION: Anastomotic pseudoaneurysm is one of the rarest vascular complications after renal transplant surgery. Therapeutic options include open surgical repair or endovascular stenting. CASE PRESENTATION: Case 1 had pseudoaneurysm involving external iliac artery and was managed by jump graft to allograft using …

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Urosepsis: Pathogenesis and Treatment

Samir Bidnur, Kymora B. Scotland

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Risk‐adjusted proposal for >60 months follow up after surgical treatment of organ‐confined renal cell carcinoma according to life expectancy

Sebastian Frees, Mohammed M. Kamal, Sebastian Nestler, Patrick Levien et autres

OBJECTIVES: To determine the long-term oncological outcome of organ-confined (<pT3) renal cell carcinoma. METHODS: We identified 889 patients with complete long-term follow-up data, who had been surgically treated for renal cell carcinoma (<T3) at our institution between 1976 and 2009. Kaplan-Meier analysis …

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The impact of time to metastasis on overall survival in patients with prostate cancer

Sebastian Frees, Shusuke Akamatsu, Samir Bidnur, Daniel Khalaf et autres

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Case ‒ Uretero-internal iliac artery fistula presenting with multiple negative angiographic studies

Gautamn Sarwal, Samir Bidnur, Edmund C.P. Chedgy, Alex Kavanagh

We report a rare case of a patient presenting with visible, unexplained hematuria and share the diagnostic challenges faced in the setting of multiple angiographic studies that failed to demonstrate an uretero-internal iliac artery fistula. Uretero-arterial fistulas (UAF) are rare, but well-recognized, …

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