Zhenquan Sun

Site-Specific and Programmable Editing of Serine and Threonine in Unprotected Peptides

Zhenquan Sun, Percy Man-Kit Liao, Adrian Kin Nam Chu, Alvin Wai Leung Lam et autres

Serine and threonine residues dominate regulatory post-translational modifications in nature, yet remain largely inaccessible to programmable chemical editing. Their weak hydroxyl nucleophilicity and the presence of multiple indistinguishable sites within proteins have prevented the development of general, site-selective strategies for modification in …

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Detecting ZDHHC acyltransferase inhibition using acylation-coupled lipophilic induction of polarization (Acyl-cLIP) or LC-MS

Wenzhe Chen, Jiaqi Zhao, Zhenquan Sun, Kewen Peng et autres

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Total Synthesis of the TIM-1 IgV Domain via N-to-C Serine/Threonine Ligation Enabled by Knorr Pyrazole Synthesis-Mediated Regeneration of Salicylaldehyde Esters

Xiaolin Cheng, Zhenquan Sun, Hongxiang Wu, Yao Xiao et autres

T-cell immunoglobulin and mucin domain-containing protein 1 (TIM-1) have recently emerged as the B-cell immune checkpoint with the potential to overcome the resistance of traditional immune checkpoint blockade therapy. However, the chemical biology of its post-translational glycosylations remains unexplored due to the …

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Pyridium-π Interaction Preserved the N,S-benzylidene Thioacetals (NTDs) in Acidolysis Enabling Efficient Protein Chemical Synthesis

Zhenquan Sun, Hongxiang Wu, Xuechen Li

The development of chemical protein synthesis enables access towards peptides and proteins with atomic-level precise modifications. However, the synthesis of aggregation-prone peptides and proteins remains a major challenge in both solid-phase peptide synthesis (SPPS) and chemical ligation. Here, we report a general …

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Exosomal integrin alpha 3 promotes epithelial ovarian cancer cell migration via the S100A7/p-ERK signaling pathway

Zeyuan Yin, Jiachen Ma, Joseph Adu‐Amankwaah, Guangyan Xie et autres

Epithelial ovarian cancer (EOC) is a highly aggressive malignancy with a poor prognosis due to late-stage diagnosis and the lack of reliable biomarkers for early detection. Exosomes, small vesicles involved in intercellular communication, play a critical role in cancer progression by promoting …

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Antibiotic candidates for Gram-positive bacterial infections induce multidrug resistance

Ana Martins, Fanni Judák, Zoltán Farkas, Petra Szili et autres

Several antibiotic candidates are in development against Gram-positive bacterial pathogens, but their long-term utility is unclear. To investigate this issue, we studied the laboratory evolution of resistance to antibiotics that have not yet reached the market. We found that, with the exception …

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Superfast Desulfurization for Protein Chemical Synthesis and Modification

Zhenquan Sun, Yihui Cao, Xuechen Li

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An integrated preventive and therapeutic magnetic nanoparticle loaded with rhamnolipid and vancomycin for combating subgingival biofilms

Wenyan Kang, Ting Zou, Ye Liang, Huaxiang Lei et autres

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Selective Peptide Cysteine Manipulation on Demand and Difficult Protein Chemical Synthesis Enabled by Controllable Acidolysis of N,S‐Benzylidene Thioacetals

Hongxiang Wu, Zhenquan Sun, Xuechen Li

Although solid-phase peptide synthesis combining with chemical ligation provides a way to build up customized polypeptides in general, many targets are still presenting challenges for the conventional synthetic process, such as hydrophobic proteins. New methods and strategies are still required to overcome …

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Selective Peptide Cysteine Manipulation on Demand and Difficult Protein Chemical Synthesis Enabled by Controllable Acidolysis of N,S‐Benzylidene Thioacetals

Hongxiang Wu, Zhenquan Sun, Xuechen Li

Abstract Although solid‐phase peptide synthesis combining with chemical ligation provides a way to build up customized polypeptides in general, many targets are still presenting challenges for the conventional synthetic process, such as hydrophobic proteins. New methods and strategies are still required to …

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Precision in protein chemical modification and total synthesis

Zhenquan Sun, Han Liu, Xuechen Li

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N,O‐Benzylidene Acetal Dipeptides (NBDs) Enable the Synthesis of Difficult Peptides via a Kinked Backbone Strategy

Hongxiang Wu, Zhenquan Sun, Xuechen Li

Proteins with highly hydrophobic regions or aggregation-prone sequences are typically difficult targets for chemical synthesis at the current stage, as obtaining such type of peptides via solid-phase peptide synthesis requires sophisticated operations. Herein, we report N,O-benzylidene acetal dipeptides (NBDs) as robust and …

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