Feng Ye

Adjuvant Sintilimab Plus Bevacizumab After Curative Resection of Spontaneously Ruptured Hepatocellular Carcinoma: Protocol for a Prospective, Exploratory, Single-Arm Study (CLEAR-2)

Yuan Cheng, Feng Ye, Hui‐Chuan Sun, Yongjun Chen

Background: Spontaneous rupture of hepatocellular carcinoma (srHCC) is a life-threatening complication associated with high perioperative mortality and increased postoperative recurrence, particularly peritoneal dissemination. Although timely haemostasis and curative-intent resection allow selected patients to achieve meaningful survival, postoperative management remains poorly defined, and …

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Advances in general surgery: integrating innovation into surgical specialty education and global practice

Feng Ye, Qian Gu, Duan Cai, Weiguo Hu

Abstract General surgery has undergone transformative changes driven by technological innovations, evolving surgical paradigms, and persistent global disparities in education and practice. This review synthesizes contemporary developments in general surgery, with a focus on integrating innovation into surgical education and clinical practice. …

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Spontaneous Rupture of Hepatocellular Carcinoma: Pathogenesis, Clinical Management, Prognostic Factors, and Future Directions

Yuan Cheng, Feng Ye, Yongjun Chen

Spontaneous rupture of hepatocellular carcinoma (srHCC) is a life-threatening complication with complex pathophysiology and heterogeneous clinical presentations. This review aims to provide an up-to-date summary of the pathogenesis, clinical features, treatment strategies, prognostic factors, and emerging research in srHCC. We discuss current …

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Teaching design for chapter “primary liver cancer” in surgery course based on the clinical theory and clerkship synchronization model in the era of New Medicine

Feng Ye, Qiang Cai, Xiaoyong Gong, Jiajun Ren et autres

Abstract Objectives The chapter on primary liver cancer in the surgery course is designed to align with the New Medicine paradigm, emphasizing the integration of clinical theory with clerkship experiences to foster a comprehensive understanding of the disease. Methods The teaching design …

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The pattern of tumor progression on first-line immune checkpoint inhibitor-based systemic therapy for Chinese advanced hepatocellular carcinoma –CLEAP 004 study

Chao-Xu Yang, Yangxun Pan, Feng Ye, Xiao‐Dong Zhu et autres

Background: For decades, stratification criteria for first-line clinical studies have been highly uniform. However, there is no principle or consensus for restratification after systemic treatment progression based on immune checkpoint inhibitors (ICIs). The aim of this study was to assess the patterns …

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Cancer-associated fibroblast-derived exosome miR-181b-3p promotes the occurrence and development of colorectal cancer by regulating SNX2 expression

Yimei Jiang, Qingqing Qiu, Xiaoqian Jing, Zijia Song et autres

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Development and validation of risk score for predicting spontaneous rupture of hepatocellular carcinoma

Feng Ye, Di Ma, Xiaoyong Gong, Yuchen Yang et autres

PURPOSE: Spontaneous rupture is a potentially serious complication of liver cancer. A risk score was developed and validated for predicting spontaneous rupture based on a retrospective study. METHODS: Multiple logistic regression analysis was used to study the relationship between clinical variables and …

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