Swati Garg

Leukemic Stem Cell Subtypes Drive Distinct Niche Remodeling in Acute Myeloid Leukemia

Karin D. Prummel, Anna Mathioudaki, Ivan Berest, Shubhankar Sood et autres

ABSTRACT Leukemic stem cells (LSCs) sustain acute myeloid leukemia (AML) and are implicated in therapy resistance and relapse. Yet, it remains unknown how LSCs remodel the bone marrow niche. AML is known to alter stromal and vascular microenvironments, but these effects are …

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Dual CDK2 and CDK4/6 inhibition suppresses Rb/E2F signaling and enhances anti-leukemic activity in acute myeloid leukemia

Ellen Weisberg, Basudev Chowdhury, Swati Garg, Taisei Akatsu et autres

The cyclin-dependent kinase 6 (CDK6) is a central regulator of cell cycle progression and an important contributor to the development of acute leukemia, particularly in poor prognosis subtypes. Preclinical studies have demonstrated activity of CDK6-targeting drugs in acute myeloid leukemia (AML) and …

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A novel combination approach targeting P300 and DNA-PK exploits epigenetic dependencies in acute myeloid leukemia

Srinivas Vinod Saladi, Swati Garg, Ellen Weisberg, Abigail E. Case et autres

Acute myeloid leukemia (AML) is characterized by poor survival, especially in older patients with relapse/refractory disease. With an apparent lack of reliable long-term treatments, pathways involved in chromatin regulation represent potentially leverageable targets. The arginine methyltransferase CARM1 is a known dependency in …

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Mendelian susceptibility to mycobacterial disease: Clinical, immunological, and genetic study in India

Aparna Dalvi, Lavina Temkar, Mukesh Desai, Swati Garg et autres

Mendelian susceptibility to mycobacterial disease (MSMD) is a rare syndrome characterized by increased and selective susceptibility to weakly virulent mycobacteria and other intramacrophagic pathogens. This study emphasizes the utility of immunological and functional assays in diagnosing MSMD by analyzing clinical, immunological, and …

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Phosphatidic acid phosphatase LPIN1 in phospholipid metabolism and stemness in hematopoiesis and AML

Karin Huber, Swati Garg, Lena P. Schlautmann, Rui Wang et autres

Abstract Targeting metabolism represents a promising approach to eradicate leukemic stem cells (LSCs) that are considered critical drivers of relapse in acute myeloid leukemia (AML). In this study, we demonstrate that the phosphatidic acid phosphatase LPIN1, which regulates the synthesis of diacylglycerol, …

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Dual CARM1-and IKZF3-targeting: A novel approach to multiple myeloma therapy

Wei Ni, Swati Garg, Basudev Chowdhury, Martin Sattler et autres

[This corrects the article DOI: 10.1016/j.omton.2025.200952.].

Dual CARM1-and IKZF3-targeting: A novel approach to multiple myeloma therapy

Wei Ni, Swati Garg, Basudev Chowdhury, Martin Sattler et autres

Advancements in the treatment of multiple myeloma (MM) have resulted in an improvement in the survival rate. However, there continues to be an urgent need for improved therapies. The protein arginine methyltransferase, CARM1 (coactivator associated arginine methyltransferase 1), is emerging as a …

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BRD9 regulates normal human hematopoietic stem cell function and lineage differentiation

Swati Garg, Wei Ni, Basudev Chowdhury, Ellen Weisberg et autres

Bromodomain containing protein 9 (BRD9), a member of the non-canonical BRG1/BRM-associated factor (ncBAF) chromatin remodeling complex, has been implicated as a synthetic lethal target in AML but its function in normal human hematopoiesis is unknown. In hematopoietic stem and progenitor cells (HSPC) …

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Absent Sounds: Use of Haptic Devices for LVAD Alarms in a Patient with Hearing Loss

Ali Jawaid, Melissa M. Thomas, Farah S. Hussain, Swati Garg et autres

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Synergy between BRD9- and IKZF3-Targeting as a Therapeutic Strategy for Multiple Myeloma

Basudev Chowdhury, Swati Garg, Wei Ni, Martin Sattler et autres

Progress in the treatment of multiple myeloma (MM) has resulted in improvement in the survival rate. However, there is still a need for more efficacious and tolerated therapies. We and others have shown that bromodomain-containing protein 9 (BRD9), a member of the …

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Chimeric Antigen Receptor T Cell Therapy in Acute Myeloid Leukemia: Trials and Tribulations

Swati Garg, Wei Ni, James D. Griffin, Martin Sattler

Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy that is often associated with relapse and drug resistance after standard chemotherapy or targeted therapy, particularly in older patients. Hematopoietic stem cell transplants are looked upon as the ultimate salvage option with curative …

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Hypomethylating agent decitabine sensitizes diffuse large B-cell lymphoma to venetoclax

Fen Zhu, Jennifer L. Crombie, Wei Ni, Nguyet-Minh Hoang et autres

Despite recent advances in the therapy of diffuse large B-cell lymphoma (DLBCL), many patients are still not cured. Therefore, new therapeutic strategies are needed. The anti-apoptotic B-cell lymphoma 2 (BCL2) gene is commonly dysregulated in DLBCL due to various mechanisms such as …

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