Lei Yang

Predicting immunohistochemical expression status and molecular subtypes using synthetic magnetic resonance imaging and multiple multiplexed sensitivity encoding diffusion weighted imaging in breast cancer: a prospective study

Lei Yang, Haifei Lan, Yang Li, Zaixian Zhang et autres

To evaluate and compare the performance of synthetic magnetic resonance imaging (SyMRI) and multiple multiplexed sensitivity encoding diffusion weighted imaging (MUSE DWI) in predicting the expression status of immunohistochemistry (IHC) markers and molecular subtypes in patients with breast cancer. This prospective study …

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Impact of Riolan arch and mesenteric vascular anatomy on tissue oxygenation in rectal cancer surgery: A prospective study on inferior mesenteric artery ligation strategies

Yudong Zhang, Lei Yang, Shuai Jing, Liangang Ma et autres

BACKGROUND: The optimal management of the inferior mesenteric artery during rectal cancer surgery, specifically whether to preserve the left colic artery using low-tie ligation or perform high-tie ligation, remains a subject of debate. This study aims to propose a preoperative strategy for …

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Splice-switching of the oncogenic BCS1L isoform suppresses ovarian cancer progression by disrupting mitochondrial function

Zhaojian Liu, Meining Xu, Zixiang Wang, Siyuan Yang et autres

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Isoform switching of CD47 induces macrophage-initiated cancer cell pyroptosis

Zhaojian Liu, Zixiang Wang, Lei Yang, Siyuan Yang et autres

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An Enhanced CT-based Radiomics Model for Predicting the Anaplastic Lymphoma Kinase Mutation Status in Lung Adenocarcinoma

Zaixian Zhang, Taijuan Zhang, Hui Ding, Shunli Liu et autres

Introduction: This study aimed to explore the relationship between radiomics features and anaplastic lymphoma kinase (ALK) gene mutation status in lung adenocarcinoma and to develop a radiomics nomogram for preoperative prediction of ALK mutations. Methods: A retrospective analysis was conducted on 210 …

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Early diagnostic challenges of isolated ocular motor nerve palsy: diabetic, ischemic, or Tolosa-Hunt Syndrome

Ling Yu, Wei Qin, Wenli Hu, Lei Yang

Objective Investigating the clinical features and etiological diagnosis of early isolated ocular motor nerve palsy to deepen understanding of the condition. Methods We retrospectively enrolled 68 patients with isolated ocular motor nerve palsy admitted our hospital between 2017 and 2024. A retrospective …

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METTL3-mediated m⁶A methylation in cardiac diseases: pathogenic roles and therapeutic potential

Ruida Liu, Xiaojuan Su, Lei Yang, Dongqiong Xiao

Cardiac dysfunction is a leading cause of death each year, putting heavy burdens on the global healthcare system. To improve our understanding of cardiac disease, novel perspectives for exploring their pathogenesis mechanisms are needed, which contributes to finding novel diagnoses and therapy …

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Analysis of Cardiovascular and Cerebrovascular Prognosis and Risk Factors in Patients with Primary Membranous Nephropathy

Nan Ye, Lei Yang, Guoqin Wang, Wenrong Cheng et autres

Key Points Higher serum phospholipase A2 receptor antibody is an independent risk factor of arterial and venous thromboembolic events in patients with primary membranous nephropathy. The inflammatory system may play a role in this relationship. Background This study investigated risk factors and …

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A bioactive hydrogel patch accelerates revascularization in ischemic lesions for tissue repair

Zhuo Liu, Kang‐Hsi Wu, Hong Zeng, Wenxin Huang et autres

Abstract Background Magnesium ions play crucial roles in maintaining cellular functions. Research has shown that Mg2+ can promote angiogenesis, indicating its potential for treating cardiovascular ischemic diseases. However, conventional intravenous or oral administration of Mg2+ presents several challenges, including the risk of …

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A bibliometric analysis of root canal irrigation: From laboratory to clinical practice

Yudi Deng, Jinglan Zhang, Xinran Wang, Lei Yang et autres

The study aims to conduct a bibliometric analysis on root canal irrigation to elucidate the development of this domain and pose the future research trends. Of 6722 articles retrieved from Clarivate Analytics' Web of Science Core Collection and PubMed, 6650 publications were …

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Effect of Early Oral Administration of Doxycycline on Macrolide Resistance in Children with Mycoplasma Pneumoniae Pneumonia: A Retrospective Study

Bingbing Cai, Lei Yang, Xin Li, Xin Zhang

Aims/Background Mycoplasma pneumoniae pneumonia (MPP) is typically a benign and self-limiting disease. This study aimed to investigate the effect of early oral administration of doxycycline on macrolide resistance in children with MPP. Methods This study retrospectively analyzed the clinical data of 173 …

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SARS-CoV-2 Protein Deposition Enhances Renal Complement Activation and Aggravates Kidney Injury in Membranous Nephropathy after COVID-19

Hong Cheng, Guoqin Wang, Lei Yang, Xiaoyi Xu et autres

Background: COVID-19 has been reported to be associated with the occurrence and recurrence of membranous nephropathy (MN). The clinicopathological characteristics and complement system activation of MN after COVID-19 are unclear. Methods: A total of 38 patients with biopsy-proven MN who developed new …

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