Accès ouvert
2025
article
OpenAlex
Julieta S. del Valle, Ruben W Van Helden, Ioannis Moustakas, Wei En Fu et autres
Tissue fibrosis, with the excessive accumulation of extracellular matrix, leads to organ dysfunction. The ovary shows signs of fibrosis from an early age, creating a permissive environment for ovarian cancer. A robust culture-platform to study human ovarian fibrosis would enable screens for …
nl, be
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Accès ouvert
2024
article
OpenAlex
Hui Cheng, Wei Fu, Julieta S. del Valle, Tessa H R Stolk et autres
STUDY QUESTION: Can secondary follicles be obtained from cultured cryopreserved-thawed human ovarian cortical tissue? SUMMARY ANSWER: We obtained high-quality secondary follicles from cultured cryopreserved-thawed human ovarian cortical tissue from cis female donors (cOVA), but not from trans masculine donors (tOVA) in the …
nl, dk, us, cz, be
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Julieta S. del Valle, Azra Husetic, Dina Diek, Laurens Rutgers et autres
The ovarian surface epithelium (OSE), the outermost layer of the ovary, undergoes rupture during each ovulation and plays a crucial role in ovarian wound healing while restoring ovarian integrity. Additionally, the OSE may serve as the source of epithelial ovarian cancers. Although …
nl
(code pays fourni par la source)
2024
conference-abstract
OpenAlex
Fu‐Chan Wei, Hanrong Cheng, Xueli Fan, Julieta S. del Valle et autres
Abstract Study question How does the ovarian microenvironment, involving neural fibers, vascular networks, and immune cells, interplay with follicular dynamics in the human adult ovary? Summary answer Neural fibers growing into the ovarian cortex and vascular network expansion were associated with primordial …
nl, be
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Joyce Danielle Asseler, Julieta S. del Valle, Susana M. Chuva de Sousa Lopes, Marieke O. Verhoeven et autres
Transmasculine people usually reach amenorrhea within 6 months of adequate testosterone treatment. It is often assumed that no ovulation occurs during amenorrhea. However, in this study, we report recent ovulatory activity in amenorrheic transmasculine people on testosterone therapy at gender-affirming oophorectomy. Histological …
nl, be
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Wei Fu, Xueying Fan, Julieta S. del Valle, Joyce Danielle Asseler et autres
The reproductive lifespan in humans is regulated by a delicate cyclical balance between follicular recruitment and atresia in the ovary. The majority of the small antral follicles present in the ovary are progressively lost through atresia without reaching dominance, but this process …
nl, be
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Julieta S. del Valle, Susana M. Chuva de Sousa Lopes
Ovarian dysfunction poses significant threats to the health of female individuals. Ovarian failure can lead to infertility due to the lack or inefficient production of fertilizable eggs. In addition, the ovary produces hormones, such as estrogen and progesterone, that play crucial roles …
nl, be
(code pays fourni par la source)
Accès ouvert
2023
conference-abstract
OpenAlex
Hanrong Cheng, Shanshan Chen, Julieta S. del Valle, Xueying Fan et autres
Abstract Study question Can we obtain secondary follicles from cultured cryopreserved-thawed human cortical tissue? Summary answer We obtained a comparable percentage of secondary follicles after culture of cryopreserved-thawed human cortical tissue to that reported after culture of fresh human cortical tissue. What …
nl, be
(code pays fourni par la source)
Accès ouvert
2023
conference-abstract
OpenAlex
Julieta S. del Valle, Ruben W.J. van Helden, Joyce Danielle Asseler, Leoni A. Louwé et autres
Abstract Study question Could the excess deposition of fibrotic collagen and the presence of myofibroblast be reversed by in vitro culture of human cortical tissue with antifibrotic targets? Summary answer The in vitro treatment of fibrotic ovarian stroma with Metformin, Pirfenidone or …
nl
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Julieta S. del Valle, Vanessa Mancini, Maitane Laverde Garay, Joyce Danielle Asseler et autres
Current strategies for fertility preservation include the cryopreservation of embryos, mature oocytes or ovarian cortical tissue for autologous transplantation. However, not all patients that could benefit from fertility preservation can use the currently available technology. In this regard, obtaining functional mature oocytes …
nl, be
(code pays fourni par la source)
Accès ouvert
2022
conference-abstract
OpenAlex
Julieta S. del Valle, Joyce Danielle Asseler, Xueli Fan, L.A Louwe et autres
Abstract Study question Can cryopreserved-thawed human ovarian cortex be cultured in vitro to produce growing follicles as efficiently as from fresh samples? Summary answer In contrast to fresh samples, cryopreserved-thawed ovarian cortex did not develop morphologically normal growing follicles, even when adding …
nl
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Xueying Fan, Ioannis Moustakas, Monika Bialecka, Julieta S. del Valle et autres
Human ovarian folliculogenesis is a highly regulated and complex process. Characterization of follicular cell signatures during this dynamic process is important to understand follicle fate (to grow, become dominant, or undergo atresia). The transcriptional signature of human oocytes and granulosa cells (GCs) …
nl, be
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