Takatoshi Maeyama

Age‐related variations in prostaglandin E‐major urinary metabolite values in Japanese children

Takatoshi Maeyama, Ayaka Takashiba, Ayaha Hata, Keinosuke Hizuka et autres

BACKGROUND: Prostaglandin E-major urinary metabolite (PGE-MUM) is an emerging noninvasive biomarker used to evaluate clinical and endoscopic activity in patients with inflammatory bowel disease. Previous studies have shown that PGE-MUM values correlate with colonic inflammation in pediatric ulcerative colitis; however, reference values …

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Sibling cases of congenital hypogonadotropic hypogonadism harboring compound heterozygous KISS1R variants

Yuki Miyahara, Kenichi Yamamoto, Ayaha Hata, Takatoshi Maeyama et autres

l Compound heterozygous KISS1R variants were identified in two siblings with congenital hypogonadotropic hypogonadism.l The p.Pro147Leu variant has been reported as pathogenic.l Familial assessment reclassifies the p.Met136Arg variant as likely pathogenic.

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Hydrocortisone dosage at 3 years of age is positively correlated with body mass index at 10 years in individuals with 21-hydroxylase deficiency

Yuki Miyahara, Ayaha Hata, Tamaki Wada, Takatoshi Maeyama et autres

Obesity is a major complication in individuals with 21-hydroxylase deficiency (21-OHD) and excessive hydrocortisone (HC) dosing is a likely contributing factor. However, the association between the HC dosage and body mass index (BMI) during childhood remains unclear. We previously reported a positive …

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Chronic intestinal pseudo-obstruction complicated with sand-like enterolithiasis: case report

Yoshikazu Miura, Shin‐ichiro Hagiwara, Keinosuke Hizuka, Ryutaro Saura et autres

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Efficacy of Acotiamide in Pediatric Patients with Functional Dyspepsia

Keinosuke Hizuka, Shin‐ichiro Hagiwara, Ryutaro Saura, Yu Masuda et autres

Purpose: Functional dyspepsia (FD) is a chronic disorder characterized by upper abdominal symptoms in the absence of an identifiable organic cause.Although the efficacy of acotiamide has been demonstrated in adults with FD, its effectiveness in pediatric patients remains unclear.This study aimed to …

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Changes in body mass index during chemotherapy are positively associated with height outcome in childhood cancer survivors of acute lymphoblastic leukemia

Tamaki Wada, Ayaha Hata, Takatoshi Maeyama, Shinobu Ida et autres

Impaired linear growth is an important morbidity in childhood cancer survivors (CCS); however, chemotherapy-associated factors that affect height outcomes remain elusive. Accordingly, we conducted a single-center, retrospective cohort study that included survivors of childhood-onset acute lymphoblastic leukemia (ALL) diagnosed between 2002 and …

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Genetic backgrounds and genotype-phenotype relationships in anthropometric parameters of 116 Japanese individuals with Noonan syndrome

Yasuko Shoji, Ayaha Hata, Takatoshi Maeyama, Tamaki Wada et autres

Noonan syndrome (NS) is caused by pathogenic variants in genes encoding components of the RAS/MAPK pathway and presents with a number of symptoms, including characteristic facial features, congenital heart diseases, and short stature. Advances in genetic analyses have contributed to the identification …

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Validation of the simplified PIBD ‐classes criteria: A single‐center retrospective study

Yoshikazu Miura, Shin‐ichiro Hagiwara, Keinosuke Hizuka, Ryutaro Saura et autres

BACKGROUND: Pediatric inflammatory bowel disease (PIBD) subtypes are classified according to the PIBD-classes criteria, comprising 23 items. These criteria were later simplified to 19 diagnostic items. Inflammatory bowel diseases (IBDs) are classified as ulcerative colitis (UC), atypical UC, IBD-unclassified (IBD-U), Crohn's disease …

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Utility of a rapid assay for prostaglandin E-major urinary metabolite as a biomarker in pediatric ulcerative colitis

Shin‐ichiro Hagiwara, Naoki Abe, Kenji Hosoi, Tomoko Hara et autres

Prostaglandin E-major urinary metabolite (PGE-MUM) is a urinary biomarker reflecting ulcerative colitis (UC) activity. This prospective observational study aimed to evaluate the usefulness of PGE-MUM via rapid chemiluminescent enzyme immunoassay in detecting endoscopic remission (ER) and histologic remission (HR) in pediatric UC …

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A case of early-onset idiopathic chronic pancreatitis associated with a loss-of-function TRPV6 p.R483Q variant successfully treated by pancreatic duct stenting

Mizuki Goma, Shin‐ichiro Hagiwara, Tamaki Wada, Takatoshi Maeyama et autres

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Utility of a rapid assay for Prostaglandin E-major urinary metabolite as a biomarker in pediatric ulcerative colitis

Shin‐ichiro Hagiwara, Naoki Abe, Kenji Hosoi, Tomoko Hara et autres

Abstract Prostaglandin E-major urinary metabolite (PGE-MUM) is a urinary biomarker reflecting ulcerative colitis (UC) activity. This prospective observational study aimed to evaluate the usefulness of PGE-MUM via rapid chemiluminescent enzyme immunoassay in detecting endoscopic remission (ER) and histologic remission (HR) in pediatric …

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Dosage of hydrocortisone during late infancy is positively associated with changes in body mass index during early childhood in patients with 21-hydroxylase deficiency

Tamaki Wada, Satsuki Nishigaki, Ayaha Hata, Takatoshi Maeyama et autres

Obesity is a major complication in children with 21-hydroxylase deficiency (21-OHD). There is evidence to show that higher body mass index (BMI) during infancy and early childhood is associated with an increased risk for the subsequent development of obesity in the general …

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