Isabella Caligiuri

Peptide-Functionalized Gold Nanoparticles Targeting PD-L1: Design via a Molecular Dynamic Driven Approach and Further Experimental Validation

Micaela Giannetti, Marina Gobbo, Lucio Litti, Isabella Caligiuri et autres

The development of theranostic tools for the early detection and localization of tumors represents a major challenge in oncology. Among emerging strategies, the targeting of Programmed Death Ligand-1 (PD-L1), a key immune checkpoint protein overexpressed in many tumor types, has gained significant …

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Albumin-coated VS1 nanocrystals enable STARD3 inhibition and potentiate fluoropyrimidine therapy in colorectal cancer

Isabella Caligiuri, Alessandro Bregalda, Gloria Saorin, Luisa M. R. Napolitano et autres

ABSTRACT Poor aqueous solubility remains a major obstacle to the translational development of targeted anticancer compounds. VS1, a first-in-class inhibitor of the cholesterol-transfer protein STARD3, has emerged as a promising chemosensitizing agent in colorectal cancer (CRC), but its clinical applicability is limited …

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CCDC 2518455: Experimental Crystal Structure Determination

Tommaso Lorenzon, Alessia Schiavo, Anita Piccoli, Nicolò Perin et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2518454: Experimental Crystal Structure Determination

Tommaso Lorenzon, Alessia Schiavo, Anita Piccoli, Nicolò Perin et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2518450: Experimental Crystal Structure Determination

Tommaso Lorenzon, Alessia Schiavo, Anita Piccoli, Nicolò Perin et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2518449: Experimental Crystal Structure Determination

Tommaso Lorenzon, Alessia Schiavo, Anita Piccoli, Nicolò Perin et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2518447: Experimental Crystal Structure Determination

Tommaso Lorenzon, Alessia Schiavo, Anita Piccoli, Nicolò Perin et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2518453: Experimental Crystal Structure Determination

Tommaso Lorenzon, Alessia Schiavo, Anita Piccoli, Nicolò Perin et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2518448: Experimental Crystal Structure Determination

Tommaso Lorenzon, Alessia Schiavo, Anita Piccoli, Nicolò Perin et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2518451: Experimental Crystal Structure Determination

Tommaso Lorenzon, Alessia Schiavo, Anita Piccoli, Nicolò Perin et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2518446: Experimental Crystal Structure Determination

Tommaso Lorenzon, Alessia Schiavo, Anita Piccoli, Nicolò Perin et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2518456: Experimental Crystal Structure Determination

Tommaso Lorenzon, Alessia Schiavo, Anita Piccoli, Nicolò Perin et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …