Wandi Xu

Rimegepant for vestibular and cochlear symptoms associated with vertigo in a real-world retrospective study

Ziyu Zhai, En-jiang Tian, Wandi Xu, Jun Wang et autres

Vertigo commonly co-occurs with cochlear symptoms, yet evidence for calcitonin gene-related peptide (CGRP) receptor antagonists across audiovestibular disorders remains limited. We retrospectively evaluated 54 adults with vertigo who received rimegepant 75 mg daily or every other day for 8 weeks. Rimegepant use …

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Migraine and auditory dysfunction: beyond comorbidity

Wandi Xu, Ni Zhai, Jingyu Chen, Shun Zhou et autres

Migraine operates as a systemic disorder of multisensory sensitization. Within this spectrum, auditory manifestations, including sensorineural hearing loss, tinnitus, and hyperacusis, represent prevalent yet frequently overlooked otologic phenotypes. Epidemiological data show that 15%–49% of migraine patients present with comorbid auditory symptoms, and …

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Vestibular Dysfunction and Binocular Vision Impairment: A New Clinical Perspective

Xixi Yu, E. Tian, Jun Wang, Zhaoqi Guo et autres

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Migraine-induced cochlear injury triggers ZBP1-mediated PANoptosis via CGRP signaling

Wandi Xu, Ni Zhai, Jingyu Chen, Shun Zhou et autres

OBJECTIVE: Consequences of hearing abnormalities in migraine remain largely unexplored, particularly regarding peripheral outcomes. This study aims to explore how migraine induces peripheral auditory injury and what role calcitonin gene-related peptide (CGRP) plays in the inner ear, which may contribute to the …

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Aerobic Exercise Promotes Hippocampal Neurogenesis and Ameliorates Cognitive Dysfunction Induced by Unilateral Labyrinthectomy

Zhanghong Zhou, Xixi Yu, E. Tian, Zhaoqi Guo et autres

AIMS: Vestibular dysfunction is strongly linked to cognitive impairment and dementia risk, yet its underlying mechanisms remain unclear, hindering treatment development. As a primary physical therapy intervention, aerobic exercise improves cognitive dysfunction. Thus, we investigated its potential to reverse cognitive deficits after …

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Orexin promotes vestibular compensation via projection from lateral hypothalamus to medial vestibular nucleus

Engang Tian, Jun Wang, Yixu Wang, Yuejin Zhang et autres

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Cognitive impairments and neurobiological changes induced by unilateral vestibular dysfunction in mice

Zhanghong Zhou, Engang Tian, Jun Wang, Zhaoqi Guo et autres

The vestibular system is essential for balance and spatial orientation, and its dysfunction can lead to cognitive deficits. This study investigates the effects of unilateral vestibular dysfunction (UVL) on cognitive function and the underlying neurobiological changes in mice. We established a unilateral …

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Pediatric Ménière’s disease with disassociated cochlear and vestibular symptoms: a case report

Wandi Xu, Xiaoyi Li, Xiaofei Li, Daogong Zhang et autres

Background: Typical Ménière's disease (MD) rarely occurs in childhood. Compared to adults, age-associated changes in vestibular function can occur during infancy and childhood. Previous case reports may have lacked some audiovestibular tests in children. It is worthwhile to follow a child with …

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Ménière’s disease and allergy: Epidemiology, pathogenesis, and therapy

Wandi Xu, Xiaofei Li, Yongdong Song, Ligang Kong et autres

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Protective effect of anakinra on audiovestibular function in a murine model of endolymphatic hydrops

Na Zhang, Na Li, Siyue Wang, Wandi Xu et autres

Introduction: Ménière's disease (MD), a common disease in the inner ear, is characterized by an increase in endolymph in the cochlear duct and vestibular labyrinth. The pathophysiology of the condition appears to be the immune response. Studies have shown that basal levels …

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Surgical Resection Is Still Better Than Endoscopic Resection for Patients With 2-5 cm Gastric Gastrointestinal Stromal Tumours: A Propensity Score Matching Analysis

Hao Wu, Han Li, Qinfeng Xu, Liang Shang et autres

BACKGROUND: The management of 2-5 cm gastric gastrointestinal stromal tumours (GISTs) is still debated between surgeons and endoscopists. We aimed to investigate short-term and long-term outcomes between surgical resection (SR) and endoscopic resection (ER). METHODS: This study included 67 and 215 patients …

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