Jie Zhao

lncRNAs contribute to caste differentiation as a regulatory layer in ants

Guo Ping Ding, Fuqiang Lin, Jixuan Zheng, Dashuang Zuo et autres

Abstract Caste differentiation in ants represents one of the major evolutionary transitions and provides a unique model for studying developmental mechanisms underlying division of labor. Genetically identical individuals follow divergent epigenetically-regulated developmental trajectories that give rise to morphologically distinct phenotypes and specialized …

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Distinct Roles of Two UDP-N-Acetylglucosamine Pyrophosphorylase Genes in Chitin Biosynthesis and Molting of Oedaleus asiaticus (Orthoptera: Acrididae)

Haiyan Gao, Feng Yan, Elahe Rostami, Mei Liu et autres

UDP-N-acetylglucosamine pyrophosphorylase (UAP) is an essential enzyme in the insect chitin biosynthesis pathway; however, little is known regarding its molecular functions in Oedaleus asiaticus Bey-Bienko (Orthoptera: Acrididae). Here, two UAP genes, OaUAP1 and OaUAP2, were identified and characterized in O. asiaticus. The …

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Environmental exposure to bisphenol S suppresses white adipocyte beiging and energy expenditure via CYP2E1 in mice

Qi Liu, Yuancheng Shao, Jiaming Xue, Yicheng Jiang et autres

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Intermittent ketogenic diet promotes Treg differentiation and alleviates Crohn’s disease via the β-hydroxybutyrate driven AHCY–DNMT1–Foxp3 axis

Shaoqi Cheng, Chao Cheng, Chuanjiang Huang, Cuixia Liu et autres

BACKGROUND: Crohn's disease (CD) is characterized by epithelial barrier dysfunction and mucosal immune dysregulation. Dietary interventions have gained increasing attention as important therapeutic strategies. We evaluated whether an intermittent ketogenic diet (IKD), which elevates β-hydroxybutyrate (BHB), ameliorates CD via lysine β-hydroxybutyrylation (Kbhb) …

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Economic evaluation of icaritin versus cinobufotalin for first-line treatment of unresectable hepatocellular carcinoma

Jie Zhao, Linhui Peng, Jianwei Xuan

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LDHA facilitates immune escape in bladder cancer through H4K5 lactylation-dependent upregulation of PD-L1

Sensheng Tang, Yang Liu, Bo Jin, Tianyang Zhang et autres

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Targeting adipocyte differentiation with CRT0066101: activation of AMPK signaling in 3T3-L1 cells

Jinque Luo, Ling Wang, Li Zhang, Meijing Deng et autres

Introduction: Obesity is characterized by excessive fat accumulation resulting from adipocyte hypertrophy and hyperplasia, with adipocyte differentiation being a central process driving these changes. Methods: The anti-adipogenic effects of CRT0066101 (CRT), a pan-protein kinase D (PKD) inhibitor, were evaluated in 3T3-L1 adipocytes. …

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Generalized gingival enlargement, periodontitis, and osteonecrosis of the jaw as manifestations of IgG4-related disease: A rare case report

Jie Zhao, Yufeng Ling, Lingying Niu, Lei Zhang et autres

RATIONALE: Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated systemic fibro-inflammatory condition involving one or multiple organs. We report a rare case of IgG4-RD associated with generalized gingival enlargement, periodontitis, and osteonecrosis of the jaw in a Chinese man. PATIENT CONCERNS: A 44-year-old …

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Stem cell repair strategies for epilepsy

Ma Xiao, Zitong Wang, Jie Zhao, Xiaorui Wang et autres

Epilepsy is a serious neurological disorder; however, the effectiveness of current medications is often suboptimal. Recently, stem cell technology has demonstrated remarkable therapeutic potential in addressing various neurological diseases, igniting interest in its applicability for epilepsy treatment. This comprehensive review summarizes different …

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Camrelizumab combined with rivoceranib and TACE in the perioperative treatment of hepatocellular carcinoma: A randomized, open-label multicenter trial.

Yongxiang Xia, Xiaofeng Wu, Aihua Yao, Xiaofeng Qian et autres

e16279 Background: The high recurrence rate following resection presents a significant challenge to the survival of patients with resectable hepatocellular carcinoma (HCC). Therefore, it is imperative to develop novel and effective therapeutic interventions to reduce recurrence and improve the prognosis of patients …

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Characterization of the specific proteins to which HH-A, a drug that alleviates ischemic brain injury, binds in rat plasma

Jie Zhao, Yuandong Zheng, Lei Peng, Yuying Zhang et autres

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Sa1793: THE ROLE OF IL4:MICROBIOME INTERACTIONS IN ACUTE COLITIS

Nicolas F. Moreno, Yang Yang, Jie Zhao, Yankai Wen et autres