Charles E. McCall

Nuclear S100A9 Protein Induces Anti-Inflammatory Gene Expression in Sepsis.

Isatou Bah, Dima A. Youssef, Mary E. A. Howell, Zhi Qiang Yao et autres

may mitigate the immunosuppressive effects of MDSCs in late sepsis.

us (code pays fourni par la source)

Temporal associations of plasma levels of the secreted phospholipase A 2 family and mortality in severe COVID‐19

Eric Lu, Aki Hara, Shudong Sun, Brian Hallmark et autres

Abstract Previous research suggests that group IIA‐secreted phospholipase A 2 (sPLA 2 ‐IIA) plays a role in and predicts lethal COVID‐19 disease. The current study reanalyzed a longitudinal proteomic data set to determine the temporal relationship between levels of several members of …

us (code pays fourni par la source)

Author response for "Temporal associations of plasma levels of the secreted phospholipase A2 family and mortality in severe COVID‐19"

Eric Lu, Aki Hara, Shudong Sun, Brian Hallmark et autres

Author response for "Temporal associations of plasma levels of the secreted phospholipase A2 family and mortality in severe COVID‐19"

Eric Lu, Aki Hara, Shudong Sun, Brian Hallmark et autres

Author response for "Temporal associations of plasma levels of the secreted phospholipase A2 family and mortality in severe COVID‐19"

Eric Lu, Aki Hara, Shudong Sun, Brian Hallmark et autres

Glutathionylation of pyruvate dehydrogenase complex E2 and inflammatory cytokine production during acute inflammation are magnified by mitochondrial oxidative stress

David L. Long, Charles E. McCall, Leslie B. Poole

Lipopolysaccharide (LPS) is a known inducer of inflammatory signaling which triggers generation of reactive oxygen species (ROS) and cell death in responsive cells like THP-1 promonocytes and freshly isolated human monocytes. A key LPS-responsive metabolic pivot point is the 9 MDa mitochondrial …

us (code pays fourni par la source)

The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat

Peter W. Stacpoole, Charles E. McCall

us (code pays fourni par la source)

Glutathionylation of Pyruvate Dehydrogenase Complex E2 and Inflammatory Cytokine Production During Acute Inflammation Are Magnified By Mitochondrial Oxidative Stress

David L. Long, Charles E. McCall, Leslie B. Poole

ABSTRACT Lipopolysaccharide (LPS) is a known inducer of inflammatory signaling which triggers generation of reactive oxygen species (ROS) and cell death in responsive cells like THP-1 promonocytes and freshly isolated human monocytes. A key LPS-responsive metabolic pivot point is the 9 megadalton …

us (code pays fourni par la source)

Hotairm1 Controls S100A9 Protein Phosphorylation in Myeloid-Derived Suppressor Cells during Sepsis.

Isatou Bah, Dima A. Youssef, Zhi Qiang Yao, Charles E. McCall et autres

Hotairm1 knockdown decreases the production of the immunosuppressive cytokine IL-10. These results suggest that targeting Hotairm1 might reduce MDSC expansion during sepsis and thus relieve immunosuppression and improve survival.

us (code pays fourni par la source)

Temporal Associations of Plasma Levels of the Secreted Phospholipase A 2 Family and Mortality in Severe COVID-19

Eric Lu, Aki Hara, Shudong Sun, Brian Hallmark et autres

Abstract Previous research suggests that group IIA secreted phospholipase A 2 (sPLA 2 -IIA) plays a role in and predicts severe COVID-19 disease. The current study reanalyzed a longitudinal proteomic data set to determine the temporal (days 0, 3 and 7) relationship …

us (code pays fourni par la source)

Sepsis, pyruvate, and mitochondria energy supply chain shortage

Charles E. McCall, Xuewei Zhu, Manal Zabalawi, David L. Long et autres

Balancing high energy-consuming danger resistance and low energy supply of disease tolerance is a universal survival principle that often fails during sepsis. Our research supports the concept that sepsis phosphorylates and deactivates mitochondrial pyruvate dehydrogenase complex control over the tricarboxylic cycle and …

us (code pays fourni par la source)

Dichloroacetate improves systemic energy balance and feeding behavior during sepsis

Tae Seok Oh, Manal Zabalawi, Shalini Jain, David L. Long et autres

Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to an infection. The metabolic aberrations associated with sepsis underly an acute and organism-wide hyperinflammatory response and multiple organ dysfunction; however, crosstalk between systemic metabolomic alterations and metabolic reprogramming at organ …

us (code pays fourni par la source)