Zoie Aiken

Genomic epidemiology and longitudinal sampling of ward wastewater environments and patients reveals complexity of the transmission dynamics of bla KPC-carbapenemase-producing Enterobacterales in a hospital setting

Nicole E Stoesser, Ryan George, Zoie Aiken, Hang T. T. Phan et autres

Abstract Background Healthcare-associated wastewater and asymptomatic patient reservoirs colonized by carbapenemase-producing Enterobacterales (CPE) contribute to nosocomial CPE dissemination, but the characteristics and dynamics of this remain unclear. Methods We systematically sampled wastewater sites (n = 4488 samples; 349 sites) and patients (n …

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Genomic epidemiology and longitudinal sampling of ward wastewater environments and patients reveals complexity of the transmission dynamics of bla KPC -carbapenemase-producing Enterobacterales in a hospital setting

Nicole E Stoesser, Ryan George, Zoie Aiken, Samuel Lipworth et autres

2. Abstract Healthcare-associated wastewater reservoirs and asymptomatic gastrointestinal patient colonisation by carbapenemase-producing Enterobacterales (CPE) contribute to nosocomial CPE dissemination. We systematically sampled wastewater sites (n=4488 sampling events; 349 sites) and patients (n=1247) across six wards over 6-12 months in 2016 to better …

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Genomic epidemiology of a complex, multi-species plasmid-borne bla KPC carbapenemase outbreak in Enterobacterales in the UK, 2009-2014

Nicole E Stoesser, Anna C. Seale, Zoie Aiken, Stephanie Thomas et autres

ABSTRACT Carbapenem resistance in Enterobacterales is a public health threat. Klebsiella pneumoniae carbapenemase (encoded by alleles of the bla KPC family) is one of the commonest transmissible carbapenem resistance mechanisms worldwide. The dissemination of bla KPC has historically been associated with distinct …

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Carbapenem-resistant Enterobacteriaceae dispersal from sinks is linked to drain position and drainage rates in a laboratory model system

Paz Aranega-Bou, Ryan George, N.Q. Verlander, Susan Paton et autres

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A Large, Refractory Nosocomial Outbreak of Klebsiella pneumoniae Carbapenemase-Producing Escherichia coli Demonstrates Carbapenemase Gene Outbreaks Involving Sink Sites Require Novel Approaches to Infection Control

Valérie Decraene, Hang T. T. Phan, Ryan George, David H. Wyllie et autres

Carbapenem-resistant Enterobacteriaceae (CRE) represent a health threat, but effective control interventions remain unclear. Hospital wastewater sites are increasingly being highlighted as important potential reservoirs.

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Novel bla KPC -carrying species identified in the hospital environment

Hang T. T. Phan, Zoie Aiken, Oluwafemi Akinremi, Julie Cawthorne et autres

Abstract bla KPC , encoding one of five dominant global carbapenemase families, is increasingly identified in environmental species difficult to characterize using routine diagnostic methods, with epidemiological and clinical implications. During environmental hospital infection prevention and control investigations (Manchester, UK) we used …

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