Hidayet Tutun

Optimization of Ultrasound-Assisted Extraction of Phenolic Compounds from Salvia tomentosa via Response Surface Methodology: Evaluation of Antioxidant Activity and Phenolic Content

Melike Sultan DEMİRAĞ, Hidayet Tutun

Objective: This study aimed to optimize the ultrasound-assisted extraction (UAE) of total phenolic content (TPC) and DPPH radical scavenging activity from aerial parts of Salvia tomentosa (S. tomentosa) using Response Surface Methodology (RSM) based on a Box-Behnken design (BBD). Materials and Methods: …

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Protective effects of rosmarinic acid against carbaryl-exposed toxicity in honey bees (Apis mellifera): histopathological and molecular docking evidence

Muhammet Mükerrem KAYA, Seda Yakut, Sibel Kaymak, Melike Sultan DEMİRAĞ et autres

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The effects of infusion of wormwood (Artemisia absinthium) and European red pine (Pinus sylvestris) on honey bee health and against nosemosis

Sedat Sevin, Hidayet Tutun, Babür Erdem, Okan Can Arslan et autres

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Optimization of Ultrasound‐Assisted Extraction of Thymbra Spicata L. Using Response Surface Methodology: Polyphenol Profile and Antibacterial Activity

Muhammed Hasan Şirin, Muhammet Mükerrem KAYA, Melike Sultan DEMİRAĞ, Erhan Keyvan et autres

Thymbra spicata L. (Zahter) is a medicinal aromatic plant naturally growing in Türkiye. This study aimed to optimize ultrasound-assisted extraction (UAE) conditions using response surface methodology (RSM) to maximize its total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activity (DPPH). …

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Extracts From Grapefruit ( Citrus paradisi ) Peel via Microwave‐Assisted and Conventional Extractions: Evaluation of Nosema Infection and Toxicity in Honey Bees

Muhammet Mükerrem KAYA, Hidayet Tutun, Nilüfer Vural, Özlem Özmen et autres

BACKGROUND AND OBJECTIVES: This study aimed to assess the effects of grapefruit peel extract on bee health and its anti-nosema activity. METHODS: Conventional and microwave-assisted extractions of grapefruit peels were optimized by using the response surface method based on a central composite …

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Efficacy and safety of Moroccan and Turkish essential oils against Varroa destructor: varroacidal potency, locomotor activity impact, and mechanistic insights via molecular docking

Sedat Sevin, Hidayet Tutun, Soukaina Miloudi, Okan Can Arslan et autres

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Optimization of Phenolic and Flavonoid Extraction From Bee Bread Using Response Surface Methodology and Central Composite Design, and Evaluation of Antimicrobial Activity

Nilay Keyvan, Muhammet Mükerrem KAYA, Melike Sultan DEMİRAĞ, Murat Bayezit et autres

ABSTRACT Bee bread is a remarkable apicultural product recognized for its abundant proteins, minerals, vitamins, and phenolic compounds, which enhance its notable biological activity. This study aimed to optimize the extraction conditions to maximize the total phenolic content (TPC), total flavonoid content …

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Gastrointestinal stability and bioactivity of propolis from diverse origins

Zehra Can, Zeynep Berin Çelebi, Erol Tunca, Sevgi Kolaylı et autres

Abstract Propolis is a chemically complex bee product whose biological properties depend on its botanical and geographical origin. However, little is known about how gastrointestinal digestion affects its phenolic profile and bioactivity. In this study, twelve propolis samples from eight countries were …

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In Vitro Ocular Cytotoxicity of BEE Venom in ARPE-19, NTM5, HCET, and HCEC-12 Cell Lines

Emine Kubra Bilir, Hidayet Tutun, Sedat Sevin, Şeyda Kıvrak et autres

Bee venom (BV) is a complex natural secretion of Apis mellifera with documented anti-inflammatory, antimicrobial, and anticancer properties. Despite its therapeutic potential, safety concerns remain due to its strong cytotoxic effects, particularly in sensitive tissues such as the eye. In this study, …

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Optimization of microwave-assisted extraction to maximize phenolic content and antioxidant capacity of Salvia tomentosa using response surface methodology

Muhammet Mükerrem KAYA, Hidayet Tutun

Objective of this study was to optimise microwave-assisted extraction for maximizing the recovery of Salvia tomentosa polyphenols and antioxidant compounds by using Response Surface Methodology (RSM). A three-level trivariate Box-Behnken design (BBD) was used to optimize the total phenolic content (TPC) and …

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Evaluation of mineral composition, phenolic content, antioxidant, and antibacterial properties, and health risk assessment of Moroccan honeys

Hidayet Tutun, Abdessamad Aglagane, Sedat Sevin, Yaşar Aluç et autres

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Salvia tomentosa'nın Fenolik İçeriğini ve Antioksidan Kapasitesini En Üst Düzeye Çıkarmak İçin Mikrodalga Destekli Ekstraksiyonun Tepki Yüzey Metodolojisi Kullanılarak Optimizasyonu

Muhammet Mükerrem KAYA, Hidayet Tutun