Aldo Quattrone

MIND-based cortical similarity networks reveal distinct cortical alterations in motor subtypes of Parkinson’s disease

Maria Giovanna Bianco, Camilla Calomino, Fabiana Novellino, Marianna Crasà et autres

Parkinson's disease (PD) is a biologically heterogeneous disorder, yet conventional motor classifications may not fully reflect underlying cortical organization. We combined Morphometric INverse Divergence (MIND) networks, data-driven clustering, and explainable machine learning to investigate cortical morphometric heterogeneity in 219 patients with PD …

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Joint Risk Factor Combinations with Additive Interaction Increase the Risk of Parkinson's Disease

Andrea Quattrone, Basilio Vescio, Fulvia Arcuri, Giuseppe Chiarella et autres

BACKGROUND: Combined effects of multiple risk factors on incident late-onset Parkinson's disease (PD; LOPD) remain poorly characterized. OBJECTIVE: The objective of this study was to quantify the impact of joint risk exposures and estimate the contribution of potentially modifiable factors to incident …

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Risk of Epilepsy in People with Adult-Onset Hydrocephalus: Insights from the UK Biobank

Jolanda Buonocore, Francesco Fortunato, Enrico Fratto, Ilaria Sammarra et autres

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Multimodal radiomic and foundation-model MRI features converge on basal ganglia patterns in Parkinson’s motor subtypes

Marianna Inglese, Maria Celeste Bonacci, Jolanda Buonocore, Andrea Quattrone et autres

Parkinson’s disease (PD) comprises heterogeneous motor phenotypes, most prominently tremor-dominant (TD) and postural instability/gait difficulty (PIGD), which differ in progression, disability burden, and therapeutic response. Despite standardized Movement Disorder Society–Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) criteria, subtype classification remains partly subjective and …

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Dataset related to article: Early-onset parkinsonism with intellectual disability in an Italian family associated with a PTRHD1 variant

Pedullà Giuseppe, Maurizio Morelli, Paola Soliveri, Chiara Reale et autres

VCF data from patient IV-8 (proband), analyzed using NGS panel containing genes associated with Parkinson disease.

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Dataset related to article: Early-onset parkinsonism with intellectual disability in an Italian family associated with a PTRHD1 variant

Pedullà Giuseppe, Maurizio Morelli, Paola Soliveri, Chiara Reale et autres

VCF data from patient IV-8 (proband), analyzed using NGS panel containing genes associated with Parkinson disease.

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Morphometric Inverse Divergence Networks Combined with HYDRA Identify Parkinson’s Disease Subtypes with Distinct Transcriptomic and Serum Biomarker Profiles

Maria Giovanna Bianco, Camilla Calomino, Maria Celeste Bonacci, Maria Eugenia Caligiuri et autres

Parkinson's disease (PD) is the second most common age-related neurodegenerative disorder, yet it remains unclear whether cortical architecture can reveal biologically distinct subtypes with distinct molecular and serum biomarker signatures. Two hundred PD patients and 121 healthy controls underwent structural MRI. Subject-specific …

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Risk of epilepsy in people with adult-onset hydrocephalus: insights from the UK Biobank

Jolanda Buonocore, Francesco Fortunato, Enrico Fratto, Ilaria Sammarra et autres

AIM: We aim to determine whether individuals with adult-onset hydrocephalus have an increased risk of incident epilepsy over time. METHODS: We analysed data from the UK Biobank cohort. Diagnoses of "hydrocephalus" and "epilepsy" were identified through ICD-10-coded health records, excluding congenital and …

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Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Alberto Cacciola, Carlo Vittorio Cannistraci, Alessandro Muscoloni, Vaibhav Narula et autres

The human brain connectome is a topologically complex, spatially embedded network. One of the characteristic, basic, nonrandom rules on which brain topology relies on is the tendency of brain networks nodes to cluster into modules with high efficiency and short path length, …

Cerebral amyloid angiopathy-related inflammation (CAA-ri): an updated systematic review and meta-analysis

Vincenzo Laterza, Giuseppe Magro, Federico Tosto, Aldo Quattrone

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Thalamic Structural Connectivity Alterations in Essential Tremor Associated with REM Sleep Behaviour Disorder (P5-17.008)

Elisa Bortolin, Salvatore Mazzeo, Camilla Calomino, Rita Nisticò et autres

We aimed at investigating investigated thalamic regions in Essential Tremor (ET) patients with and without REM sleep behavior disorder (RBD), using a graph theoretical analysis.

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Reproducibility of Brain Morphometry Measurements Across Different Head Coils and Acceleration Factors on a PET/MR Scanner

Maria Celeste Bonacci, Domenico Zacà, Ilaria Chimento, Alisea Sacilotti et autres

Background/Objectives: This study evaluated the reproducibility of brain morphometric measurements obtained with different head coils and acceleration factors on a PET/MR scanner, with the aim of supporting reliability in longitudinal neuroimaging studies following major scanner hardware upgrades and introduction of higher-channel-density coils …

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