Accès ouvert
2026
article
OpenAlex
Tamara Büttner, Xiaoyan Wang, Brenda Krishnacoumar, Athanasios Papadamakis et autres
Hypoxia is a hallmark of solid tumors and represents a major barrier for effective cancer therapies, including oncolytic virotherapy. While adenoviruses are widely studied as oncolytic agents, the impact of tumor-associated hypoxia on viral infection and spatial spread remains incompletely understood. Here, …
de
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Stefanie Saoub, Eric Metzen, Basant Kumar Thakur, Yoshiyuki Henning et autres
BACKGROUND: Colorectal cancer (CRC) frequently exhibits hypoxic regions due to poor vascularization, leading to the stabilization of hypoxia-inducible factor 1 alpha (HIF-1α). Moreover, mutations in the tumour suppressor p53 occur in approximately half of all CRCs. While the individual roles of both …
de
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Stefanie Saoub, Eric Metzen, Basant Kumar Thakur, Yoshiyuki Henning et autres
Supplementary Material 1.
de
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Stefanie Saoub, Eric Metzen, Basant Kumar Thakur, Yoshiyuki Henning et autres
Supplementary Material 1.
de
(code pays fourni par la source)
Accès ouvert
2026
conference-abstract
OpenAlex
Stefanie Saoub, Eric Metzen, Basant Kumar Thakur, Yoshiyuki Henning et autres
Abstract Background Colorectal cancer (CRC) frequently exhibits hypoxic regions due to poor vascularization, leading to the stabilization of hypoxia-inducible factor 1 alpha (HIF-1α). Moreover, mutations in the tumour suppressor p53 occur in approximately half of all CRCs. While the individual roles of …
de
(code pays fourni par la source)
Accès ouvert
2026
conference-abstract
OpenAlex
Stefanie Saoub, Eric Metzen, Basant Kumar Thakur, Yoshiyuki Henning et autres
Abstract Background Colorectal cancer (CRC) frequently exhibits hypoxic regions due to poor vascularization, leading to the stabilization of hypoxia-inducible factor 1 alpha (HIF-1α). Moreover, mutations in the tumour suppressor p53 occur in approximately half of all CRCs. While the individual roles of …
de
(code pays fourni par la source)
2025
article
OpenAlex
Anna Wrobeln, Yves Schild, Lars Kleine-Möllhoff, Tristan Leu et autres
Since its approval in 2019, hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors, like roxadustat, have been used for treatment of anemia in chronic kidney disease. However, the impact of HIF stabilization on circulating leukocytes remains largely unexplored. In this study, we examined how …
de, us
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Yves Schild, Jonah Bosserhoff, Freya Droege, Elisabeth Littwitz-Salomon et autres
The interplay between hypoxia-inducible factors (HIFs) and transforming growth factor beta (TGF-β) is critical for both inflammation and angiogenesis. In hereditary hemorrhagic telangiectasia (HHT), we have previously observed that impairment of the TGF-β pathway is associated with downregulation of HIF-1α. HIF-1α accumulation …
de
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Yves Schild, Abdirizak Mohamed, Edward J. Wootton, Amy Lewis et autres
Multi-drug-resistant tuberculosis is a worldwide problem, and there is an urgent need for host-derived therapeutic targets, circumventing emerging drug resistance. We have previously shown that hypoxia-inducible factor-1α (Hif-1α) stabilisation helps the host to clear mycobacterial infection via neutrophil activation. However, Hif-1α stabilisation …
de, gb
(code pays fourni par la source)
Accès ouvert
2019
preprint
OpenAlex
Yves Schild, Abdirizak Mohamed, Edward J. Wootton, Amy Lewis et autres
Abstract Multi-drug resistant tuberculosis is a worldwide problem and there is an urgent need for host-derived therapeutic targets, circumventing emerging drug resistance. We have previously shown that hypoxia inducible-1α (Hif-1α) stabilisation helps the host to clear mycobacterial infection via neutrophil activation. However, …
de, gb
(code pays fourni par la source)