Olia Papacosta

5-028 Association between ketone body ratio and heart failure incidence: results from a 15-year prospective study

Khalil Saadeh, Olia Papacosta, Lucy Lennon, S. Goya Wannamethee

Background Heart failure (HF) is a growing public health concern with high morbidity and mortality that increase with age. Ketone bodies (KB), acetoacetate and β-hydroxybutyrate, serve as an alternative myocardial energy source, particularly under metabolic stress. KB metabolism can influence haemodynamic parameters, …

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Association of ideal cardiovascular health and Life's Simple 7 metrics with incident heart failure among older men: the British Regional Heart Study

Mehar Chawla, Olia Papacosta, Lucy Lennon, Ayesha Ahmed et autres

Abstract Aims Ideal cardiovascular health (CVH) determined by categorisation of component Life's Simple 7 (LS7) metrics has been associated with reduced risk of heart failure (HF). However, few studies have explored the relationship between changes in CVH from middle to older age …

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Carotid Intima‐Media Thickness, Carotid Distensibility, and Incident Heart Failure in Older Men: The British Regional Heart Study

Atinuke Akinmolayan, Olia Papacosta, Lucy Lennon, Elizabeth A. Ellins et autres

Background Carotid intima‐media thickness (CIMT) and carotid distensibility are markers of arterial change; however, little is known of the association with incident heart failure (HF). We aimed to assess this. Methods This was a longitudinal analysis of data from the British Regional …

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Abstract P1151: Varying Measures of Subclinical Carotid Arterial Injury and the Associations with Incident Cardiovascular Disease in Older Men: The British Regional Heart Study.

Atinuke Akinmolayan, Olia Papacosta, Lucy Lennon, Elizabeth A. Ellins et autres

Objectives Carotid intima-media thickness (CIMT) is reflective of arterial aging and injury. However, there are inconsistencies in the reported associations between CIMT measurements and CVD risk, specifically mean versus maximum CIMT, the role of carotid plaque location and quantity. This study explores …

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Association between poor oral health and deterioration of appetite in older age: results from longitudinal analyses of two prospective cohorts from the UK and USA

Suruchi G. Ganbavale, Ziyi Cai, John C. Mathers, Olia Papacosta et autres

OBJECTIVE: This study investigated the association of poor oral health with appetite loss and deterioration in appetite longitudinally in older adults. DESIGN: Cross-sectional and longitudinal observational study. SETTING: Data came from two population-based cohorts of older adults from the UK and USA. …

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Oral Health and Incident Type 2 Diabetes: A Longitudinal Analysis from the British Regional Heart Study

Pauline Sobiesuo, Rachel Kimble, Heather Brown, Roshan Varghese et autres

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Associations of social engagement and loneliness with the progression and reversal of frailty: longitudinal investigations of 2 prospective cohorts from the UK and the USA

Ziyi Cai, Olia Papacosta, Lucy Lennon, Peter H. Whincup et autres

Social connections may impact the dynamic trajectory of frailty. Using data from the British Regional Heart Study (BRHS) in the UK (n = 715) and the US Health, Aging and Body Composition (Health ABC) Study (n = 1256), we conducted multinominal regression …

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Association of Life’s Simple 7 lifestyle metric with cardiometabolic disease-free life expectancy in older British men

Qiaoye Wang, Amand F. Schmidt, Lucy Lennon, Olia Papacosta et autres

BACKGROUND: Cardiometabolic diseases (CMD), including myocardial infarction, stroke, and type 2 diabetes, are leading causes of disability and mortality globally, particularly for people at an older age. The impact of adhering to the Life's Simple 7 (LS7) on the number of years …

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Carotid Intima-media thickness, carotid distensibility and incident heart failure in older men: The British Regional Heart Study

Atinuke Akinmolayan, Olia Papacosta, Lucy Lennon, Elizabeth A. Ellins et autres

Abstract Objectives Carotid intima-media thickness (CIMT) and carotid distensibility are markers of arterial change, however little is known of the prognostic value in incident HF. We aimed to assess this prospective association. Design Longitudinal analysis of data from the British Regional Heart …

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Neighborhood Deprivation and Changes in Oral Health in Older Age: A Longitudinal Population-Based Study

Suruchi G. Ganbavale, Efstathios Papachristou, John C. Mathers, Olia Papacosta et autres

The aim of this study was to examine the extent to which neighborhood-level socioeconomic factors (objective and perceived) are associated with poor oral health in older adults over time, independent of individual socioeconomic position. Data for this cross-sectional and longitudinal observation study …

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Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease

J.C. Bis, Christopher J. O’Donnell, R. Sofat, Olia Papacosta et autres

Development of cholesteryl ester transfer protein (CETP) inhibitors for coronary heart disease (CHD) has yet to deliver licensed medicines. To distinguish compound from drug target failure, we compared evidence from clinical trials and drug target Mendelian randomization of CETP protein concentration, comparing …

Association between Oral Health and Incidence of Type 2 Diabetes Among Older British Men: A Longitudinal Analysis from the British Regional Heart Study

Pauline Sobiesuo, Rachel Kimble, Heather Brown, Roshan Varghese et autres

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