Yonghui Jiang

Hyperandrogenism drives a pathogenic adipocyte differentiation to promote insulin resistance in PMOS

Yonghui Jiang

The uploaded files include:All_celltype_data.rds: All cell types (117,457 nuclei).ASPC_data.rds: Adipose stem and progenitor cells (19,289 nuclei).Adipocyte_data.rds: Adipocytes (22,047 nuclei).

Hyperandrogenism drives a pathogenic adipocyte differentiation to promote insulin resistance in PMOS

Yonghui Jiang

The uploaded files include:All_celltype_data.rds: All cell types (117,457 nuclei).ASPC_data.rds: Adipose stem and progenitor cells (19,289 nuclei).Adipocyte_data.rds: Adipocytes (22,047 nuclei).

Hyperandrogenism drives a pathogenic adipocyte differentiation to promote insulin resistance in PMOS

Yonghui Jiang

The uploaded files include:All_celltype_data.rds RNA UMI counts and major cell-type annotations for 117,457 nuclei from human omental visceral adipose tissue. ASPC_data.rds RNA UMI counts and subpopulation annotations for 19,289 adipose stem and progenitor cell (ASPC) nuclei. Adipocyte_data.rds RNA UMI counts and subpopulation …

Hepatic Mechanisms and Therapeutic Target Underpinning Hypercoagulation in Obesity: Insights From Genetic and Transcriptomic Analyses

Shumin Li, Gengchen Feng, Xin Huang, Xiao Teng et autres

Obesity predisposes individuals to hypercoagulation, a key factor in life-threatening complications like stroke and cardiovascular disease. While clotting factors are primarily secreted by the liver, the mechanisms linking obesity to hypercoagulation remain unclear. In this study, we established an obesity cohort and …

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Generation of human pineal gland organoids with melatonin production for disease modeling

Ferdi Rıdvan Kiral, Woo Sub Yang, Onur İyilikci, Xiaona Lu et autres

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Author Correction: Data-driven subtypes of polycystic ovary syndrome and their association with clinical outcomes

Xueying Gao, Shigang Zhao, Yanzhi Du, Ziyi Yang et autres

In the version of this article initially published, there was a typo in the graph shown in Fig. 1g, where in the label now reading “SHBG-PCOS; 53%,” the percentage was originally listed as “34%.” The figure has been amended in the HTML …

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Data-driven subtypes of polycystic ovary syndrome and their association with clinical outcomes

Xueying Gao, Shigang Zhao, Yanzhi Du, Ziyi Yang et autres

Polycystic ovary syndrome (PCOS) is a common and heterogeneous endocrine disorder that affects 11%–13% of women worldwide, with profound implications for fertility and long-term metabolic health. Here we identify four reproducible subtypes—PCOS with hyperandrogen, with obesity, with high-sex hormone-binding globulin and with …

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Sexually Dimorphic Profiling of Osteoarthritis: A Comprehensive Metabolomic Dataset

Yuhan Zhang, Yonghui Jiang, Gengchen Feng, Ziyi Yang et autres

Osteoarthritis (OA) is a chronic disease characterized by high morbidity, affecting multiple body systems and associated with systemic metabolic disorders. The clinical features of OA exhibit significant sexual dimorphism. However, the specific metabolic characteristics underlying this difference remain incompletely understood, with a …

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Bioinformatic prediction of key genes involved in pro-chondrogenic effect of fragmentated cartilage transplantation

Zhu Jiang Dai, Yonghui Jiang, Ying Liao, Lin He et autres

Minced cartilage transplantation is thought to promote cartilage repair. However, the underlying mechanisms remain less well understood. In this study, we established a rat osteochondral defect model to evaluate fragment size-dependent repair efficacy, and tried to explore the mechanisms preliminarily. Herein, rats …

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Caloric restriction prevents inheritance of polycystic ovary syndrome through oocyte-mediated DNA methylation reprogramming

Yue Liu, Yi Wei Dong, Yonghui Jiang, Shan Han et autres

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snRNA-seq of human ovaries reveals heat shock proteins are associated with obesity related cancer risk

Yuhan Zhang, Yonghui Jiang, Yunhai Yu, Gengchen Feng et autres

BACKGROUND: Obesity significantly impacts female reproductive health and increases the risk of gynecological tumors. However, the specific transcriptional changes that occur in the ovarian microenvironment during obesity-induced stress and the relationship between obesity and ovarian cancer remain unclear. METHODS: Our study investigated …

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No Association of Polycystic Ovary Syndrome with Pancreatic Cancer: A Mendelian Randomization Study

Xueying Gao, Yuteng Wang, Yikun Wang, Ziyi Yang et autres

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