Xingwen Bai

The La Region of Foot-and-Mouth Disease Virus: Essential for L Protein Cellular Distribution but Not Functional Activity

Mengting Cai, H. G. Yuan, Tao Wang, Yuanfang Fu et autres

Foot-and-mouth disease virus (FMDV) is a highly contagious picornavirus that affects cloven-hoofed animals and carries significant economic implications for the global livestock industry. FMDV features two Leader (L) protein isoforms, Lab and Lb, differing at their amino termini by 28 amino acids …

cn (code pays fourni par la source)

ATG16L1 promotes virus trafficking to early endosomes and conducts its degradation by 2BC to benefit foot-and-mouth disease virus replication

Xiaohua Gong, Hong Yuan, Tao Wang, Lei Huang et autres

cn (code pays fourni par la source)

Porcine B cell receptor repertoire uncovers balanced recognition of antigenic structures on serotype Asia1 foot-and-mouth disease virus

Shulun Huang, Shanquan Wu, Fengjuan Li, Pinghua Li et autres

Of the seven serotypes of foot-and-mouth disease virus (FMDV) strains circulating globally, serotype Asia1 has been effectively eradicated in China through systematic vaccination in livestock. The structural characteristics of serotype Asia1 may enhance its immunogenicity compared to other serotypes. Herein, we present …

cn (code pays fourni par la source)

ANXA2 stabilizes mTOR at the plasma membrane to facilitate autophagic flux for CSFV release

Tao WANG, Liangcai Da, Junfang Zhao, Hong Yuan et autres

cn (code pays fourni par la source)

A chemiluminescence immunoassay for detecting neutralizing antibodies of foot-and-mouth disease virus serotype A

Mengyang Sun, Yanfang Bao, Kun Li, Yili Zuo et autres

Foot-and-mouth disease (FMD), caused by the foot-and-mouth disease virus (FMDV), is an extremely infectious disease that affects animals possessing cloven hooves. The disease spreads rapidly over long distances, with over 70 susceptible species, posing severe threats to global livestock industries (Kitching et …

cn (code pays fourni par la source)

Foot-and-mouth disease vaccine with insertion of a 24-amino acid VP1 G-H loop epitope of the Cathay virus provides broad antigenic coverage

Keqiang Zhang, Jingjing Zha, Pu Sun, Yifei Ouyang et autres

Vaccination with inactivated whole-virus vaccines remains the most effective measure for controlling foot-and-mouth disease virus (FMDV) transmission and disease outbreaks. However, the existing type O FMDV vaccines show suboptimal efficacy and antigenic mismatch to the circulating Cathay viruses in China, thus requiring …

cn (code pays fourni par la source)

Foot-and-mouth disease virus vaccine with VP1 G-H loop substitution of the Cathay strain broadens antigen spectrum

Jingjing Zha, Keqiang Zhang, Xingze Zhang, Pu Sun et autres

Recently, serotype O foot-and-mouth disease viruses (FMDVs) belonging to four lineages (O/ME-SA/PanAsia, O/ME-SA/Ind2001, O/SEA/Mya-98, and O/Cathay) co-circulate in China, and the emergence of new variant viruses belonging to the Cathay lineage renders the existing vaccines less effective, which poses a serious threat …

cn (code pays fourni par la source)

Remapping the spatial distribution of neutralizing sites and their immunodominance on the capsid of different topotypes of FMDV serotype O by site-directed competitive ELISA for detection of neutralizing antibodies

Qiongqiong Zhao, Fengjuan Li, Shulun Huang, Xiangchuan Xing et autres

The foot-and-mouth disease virus (FMDV) serotype O contains at least five neutralizing antigenic sites, yet the structural relationship and antibody abundance remain poorly characterized. This study identifies six distinct neutralizing antigenic sites by evaluating 27 host-derived neutralizing antibodies (NAbs) using competitive enzyme-linked …

cn (code pays fourni par la source)

Vaccine Prepared from Serotype O Recombinant FMDV with the Substitution of Hypervariable G-H Loop in VP1 of Cathay Virus Provides Broad Antigenic Coverage

Jingjing Zha, Keqiang Zhang, Xingze Zhang, Pu Sun et autres

cn (code pays fourni par la source)

Formononetin and mizoribine inhibit Porcine Reproductive and Respiratory Syndrome Virus replication in vitro

Zhanding Cui, Jinyi Liu, Jinlong Wang, Jing Zhang et autres

This study delves into the antiviral efficacy of Formononetin (FMN) and Mizoribine (MZR) against the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), a virus with a considerable economic impact and a current void in effective treatments. FMN and MZR were found to …

cn (code pays fourni par la source)

Establishment of a Direct Competitive ELISA for Camel FGF21 Detection

Yuxuan Yang, Hongbin Yuan, Shuqin Zhao, Yuanfang Fu et autres

Camels, with the ability to survive under drought and chronic hunger, developed exceptional efficient lipid reserves and energy substance metabolic characteristics. Fibroblast growth factor (FGF) 21 is a hormone that regulates important metabolic pathways and energy homeostasis. However, the absence of a …

cn (code pays fourni par la source)

Enhancement of immune responses to classical swine fever virus E2 in mice by fusion or mixture with the porcine IL-28B

Hong Yuan, Yunjuan Jiao, Jie Gao, Tao Wang et autres

The E2 subunit vaccine has been considered a promising alternative to an attenuated classical swine fever (CSF) vaccine. However, it fails to induce a good cellular immune response. Given that immunogenic adjuvants can regulate the cellular immunity to achieve a maximum efficacy …

cn (code pays fourni par la source)