Joost H.A. Martens

Comprehensive lincRNA Transcriptome in Acute Myeloid Leukemia: Integrating Known and Newly Identified lincRNAs Across Pediatric and Adult Cohorts

Saioa Arza-Apalategi, Daan Gilissen, Anne C. van der Grinten, Seline N. van den Oever et autres

Background/Objectives: Acute myeloid leukemia (AML) comprises genetic subclasses with distinct gene expression profiles. While AML gene expression studies have mainly focused on protein-coding genes, our understanding of expression patterns of long intergenic noncoding RNAs (lincRNAs) remains incomplete. This is due to limited …

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Identification of a robust metabolic signature associated with hospital-acquired pneumonia and response to interferon-gamma treatment in critically ill patients

Mélanie Petrier, Debajyoti Sinha, Florian P. Martin, Cécile Poulain et autres

AIM: Our objective was to increase our understanding of the effects of the time course of metabolic alterations on the risk of hospital-acquired pneumonia (HAP) and response to treatment in critically ill patients. METHODS: We first studied the blood metabolome at day …

fr, nl, au, es, gb, gr, de (code pays fourni par la source)

Persistent viral control status is associated with enhanced innate immune responses in people with HIV-1

Jéssica Cristina dos Santos, Albert L. Groenendijk, Suzanne D. E. Ruijten, Rainer Knoll et autres

The mechanisms mediating elite and persistent HIV control in people living with HIV (PLHIV) are only partially understood and largely attributed to adaptive T cell responses, but whether innate immunity also contributes remains unclear. Using samples from the 2000HIV study, we examined …

nl, de, at, be, ro (code pays fourni par la source)

Kaiso (ZBTB33) engages with non-canonical binding motifs to regulate DNA damage responses in breast cancer cells

Maximillian Rätze, Milou Tenhagen, Juul Vollaers, Christopher Benner et autres

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3046 – SUSTAINED PRC1.1 ACTIVITY PRESERVES GENE REPRESSION INDEPENDENT OF PRC2.2 AND SUPPRESSES LEUKEMIC CELL DIFFERENTIATION

Vincent van den Boom, Fatemeh Mojallali, Tjerk Jan Atsma, Alessandra De Meis et autres

Phenotypic and epigenetic profiles of circulating NK cells in spontaneous HIV-1 controllers

Albert L. Groenendijk, Adriana Navas, Nadira Vadaq, Suzanne D. E. Ruijten et autres

BACKGROUND: NK cells play a key role in eliminating HIV-infected cells, but it is unclear whether there are specific NK cell receptor signatures in spontaneous HIV controllers. METHODS: We conducted a cross-sectional analysis of circulating NK cell phenotypes in people living with …

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Long-term effects of BCG vaccination on telomere length and telomerase activity

Özlem Bulut, Valerie A. C. M. Koeken, Simone J.C.F.M. Moorlag, Charlotte J. de Bree et autres

, BCG training activated telomerase, particularly in females, and this was partially prevented by exogenous testosterone. These findings suggest BCG vaccination influences telomere dynamics in a sex-specific manner, contributing to understanding BCG's broader effects on aging-related processes.

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Editor’s Note: c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer

Angela Nebbioso, Vincenzo Carafa, Mariarosaria Conte, Francesco Paolo Tambaro et autres

cn, us (code pays fourni par la source)

C1q reprograms innate immune memory

Inge Jonkman, Maaike Jacobs, Y. Negishi, Julia I. P. van Heck et autres

Innate immune memory, also called trained immunity, is a metabolic and epigenetically regulated process that enables innate immune cells to recalibrate their inflammatory reactivity in response to pathogenic or endogenous stimuli. In addition to its function in host defense, trained immunity contributes …

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Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory

Athanasios Ziogas, Boris Novakovic, Lorenzo Ventriglia, Noriko Galang et autres

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Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory

Athanasios Ziogas, Boris Novakovic, Lorenzo Ventriglia, Noriko Galang et autres

© This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/. Deposited by shareyourpaper.org and openaccessbutton.org. We've taken reasonable steps to ensure this content doesn't violate copyright. However, if you think it does you can request a takedown by emailing …

Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory

Athanasios Ziogas, Boris Novakovic, Lorenzo Ventriglia, Noriko Galang et autres

© This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/. Deposited by shareyourpaper.org and openaccessbutton.org. We've taken reasonable steps to ensure this content doesn't violate copyright. However, if you think it does you can request a takedown by emailing …