Accès ouvert
2026
article
OpenAlex
Amaar Marefi, E Grasso, Loren McLendon, Sona Narula et autres
OBJECTIVES: Anti-interleukin 6 receptor (anti-IL6R) therapies have been proven to reduce relapse rates in patients with neuromyelitis optica spectrum disorder and are under investigation in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). One anti-IL6R therapy, tocilizumab (TCZ), has been reported as a treatment …
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2025
article
OpenAlex
Rachna Karumuri, Sam Kamoroff, Loren McLendon, Harry S. Abram
Patent foramen ovale (PFO) is a congenital cardiac anomaly resulting from the incomplete closure of the atrial septum, allowing blood to shunt from the right to the left atrium and bypass pulmonary filtration. This shunting can lead to paradoxical embolism, where emboli …
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2025
article
OpenAlex
Tristan Loveday, C. Hora, Lauren Chorny, Manisha Bansal et autres
Encephalopathy is a disturbance in neurologic function. It is commonly attributed to infectious and inflammatory etiologies but encompasses a wide differential. Hypereosinophilic syndrome (HES) is a rare cause of encephalopathy that is associated with underlying infection or malignancy. We present a pediatric …
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Accès ouvert
2025
article
OpenAlex
C. Hora, Loren McLendon
widely spaced teeth), and therefore a diagnosis of a lysosomal storage disorder was suspected.Our patient also presented with hepatosplenomegaly, umbilical hernia, frequent ear infections and mixed conductive/ sensorineural hearing loss (diagnosed via tympanograms, OAEs, and ABRs).Diagnostic Workup: His initial workup found a …
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2024
article
OpenAlex
Sam Kamoroff, Harry S. Abram, Loren McLendon
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Accès ouvert
2024
article
OpenAlex
Michael Enriquez, Scott Rosenthal, Loren McLendon, Jeffrey L. Bennett et autres
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disorder of the central nervous system caused by autoantibodies against the aquaporin-4 (AQP4) water channel. Inflammatory injury is often severe and focused on the optic nerves, spinal cord, and other CNS regions with …
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Accès ouvert
2023
article
OpenAlex
Nina Fainberg, Maya R. Silver, John D. Arena, Elizabeth I. Landzberg et autres
Background: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an inflammatory disorder of the CNS with a variety of clinical manifestations, including cerebral edema. Case Summary: A 7-year-old boy presented with headaches, nausea, and somnolence. He was found to have cerebral edema that …
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Accès ouvert
2023
article
OpenAlex
Loren McLendon, Claudia Gambrah-Lyles, Angela N. Viaene, Nina Fainberg et autres
OBJECTIVES: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an immune-mediated neuroinflammatory disorder leading to demyelination of the CNS. Interleukin (IL)-6 receptor blockade is under study in relapsing MOGAD as a preventative strategy, but little is known about the role of such treatment …
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Accès ouvert
2023
article
OpenAlex
Poorvi Agrawal, Douglas R. Nordli, Loren McLendon
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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Accès ouvert
2022
article
OpenAlex
Alexandra B. Kornbluh, Loren McLendon, Brenda Banwell
Familiarize neurologists with the association between herpes simplex encephalitis (HSE) and N-Methyl-D-aspartic acid receptor encephalitis (NMDARE). Case report and literature review We describe the case of a six-year-old boy who experienced neonatal herpes simplex virus (HSV) infection, effective early antiviral therapy, and …
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Accès ouvert
2022
article
OpenAlex
Chethan K. Rao, Loren McLendon, Fernando Galán
: We present a patient with anti-N-methyl D-aspartate receptor (NMDAR) encephalitis who presented with focal motor seizures that rapidly progressed to epilepsia partialis continua (EPC) with unilateral background slowing then encephalopathy. : A 12-year-old previously healthy girl presented to our pediatric emergency …
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2021
article
OpenAlex
Loren McLendon
To describe a case of acute demyelinating encephalomyelitis (ADEM) in infancy following SARS-CoV-2 infection.
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