M. Ménager

An integrative approach for studying immunological variation in an aging population – The Milieu Intérieur follow-up study

Anthony Jaquaniello, Florian Dubois, F. Rahal, Tom Dott et autres

Human immune responses vary across individuals due to both genetic and environmental factors. We previously established the Milieu Intérieur cohort to define boundaries of healthy immune variation and identify their determinants. To evaluate how immune responses change over time and test whether …

fr, us, ie, se, gb, ch, jp, de (code pays fourni par la source)

Thymic output in human newborns is shaped by environmental exposures and a common TCRD genetic variant

Ziyang Tan, Camille Kergaravat, Laura Gonzalez, Anette Johnsson et autres

Naïve T cell output from the thymus varies across the human lifespan and is a key determinant of health, differing between individuals by age, sex, and genetics. How thymic output is dynamically regulated early in life in response to initial microbial colonization …

se, fr, gb, us (code pays fourni par la source)

Computationnal code for analysis of patients' PBMC with Aicardi-Goutières syndrome

Maxime Batignes, Surabhi Jagtap, F. Carbone, M. Ménager

Annotated code to reproduce all computationnal analyses from the paper entitled "Pharmacological stabilization of hypoxia-inducible factor 1-alpha dampens the interferon response while favoring glycolysis pathway in Aicardi-Goutières syndrome" Batignes et al. accepted in Nature Communications in january 2026. A "Ressources" files is …

fr (code pays fourni par la source)

Computationnal code for analysis of patients' PBMC with Aicardi-Goutières syndrome

Maxime Batignes, Surabhi Jagtap, F. Carbone, M. Ménager

Annotated code to reproduce all computationnal analyses from the paper entitled "Pharmacological stabilization of hypoxia-inducible factor 1-alpha dampens the interferon response while favoring glycolysis pathway in Aicardi-Goutières syndrome" Batignes et al. accepted in Nature Communications in january 2026. A "Ressources" files is …

fr (code pays fourni par la source)

POS0728 DECIPHERING SYNOVIAL FLUID IMMUNE DYSREGULATION IN RHEUMATOID ARTHRITIS THROUGH CYTOKINE PROFILING AND SINGLE-CELL TRANSCRIPTOMICS

M. Lesturgie-Talarek, F. Carbone, V. Gonzalez, Adrien Schvartz et autres

Background: Rheumatoid arthritis (RA) is driven by the activation of complex inflammatory pathways involving immune cell infiltration into synovial tissue and fluid. Synovial fluid (SF) offers valuable insights into the pathophysiological mechanisms of joint disease. Few studies have applied advanced multiplex or …

fr (code pays fourni par la source)

Le syndrome VEXAS se caractérise par une activation des voies de l’inflammasome dans le sang et les tissus et par une dérégulation du compartiment monocytaire

B. Terrier, C. Posseme, M. Temple, A. Corneau et autres

fr (code pays fourni par la source)