Hiroki Hirao

Aberrant SOX9 expression mediated by protumour macrophages predicts poorer clinical outcomes in hepatoblastoma

Hiroki Hirao, Ahmad Adawy, Yukio Fujiwara, Daiki Yoshii et autres

Tumour-associated macrophages (TAMs) are known to promote tumour progression in many kinds of malignant tumour, including hepatoblastoma (HB). Based on previous studies, we suggested that TAM-mediated sex-determining region Y-box 9 (SOX9) signal might enhance HB progression. The present study investigated the significance …

jp, Égypte, cn (code pays fourni par la source)

Integrated transcriptomic and phenotypic analyses reveal spatiotemporal variation in neutrophil Cd14 expression after hepatectomy

Ahmad Adawy, Masaki Honda, Daiki Yoshii, Hiroki Hirao et autres

Neutrophils are key mediators of both hepatic injury and repair. This study aimed to characterize the spatiotemporal dynamics of Cd14 expression in neutrophils following hepatectomy and to explore its potential role in liver regeneration. We performed an integrated transcriptomic and phenotypic analysis …

Égypte, jp (code pays fourni par la source)

Identification of CD7 as a novel biomarker of embryonal hepatoblastoma

Ahmad Adawy, Daiki Yoshii, Hiroki Hirao, Yoshihiro Komohara et autres

Égypte, jp (code pays fourni par la source)

SOX9 Is a Key Factor for the Postnatal Maturation of the Intrahepatic Bile Duct Network

Hiroki Hirao, Daiki Yoshii, Shigeyuki Esumi, Ahmad Adawy et autres

AIM: The sex-determining region Y-box 9 (SOX9) plays a critical role in the development of intrahepatic bile ducts (IHBDs) during the embryonic stage. However, its role in postnatal IHBD maturation remains unclear. This study aimed to investigate the function of SOX9 in …

jp, Égypte (code pays fourni par la source)

Preventive role of CD163-positive macrophages in postoperative peritoneal adhesions

Lianbo Li, Hiroki Hirao, Masaki Honda, Ahmad Adawy et autres

BACKGROUND: Although abdominal surgeries can be lifesaving, they are often accompanied by the complication of peritoneal adhesion formation. While macrophages contribute to this process, the specific subtypes and underlying mechanisms remain unclear. METHODS: We aimed to identify and investigate the roles of …

cn, jp, Égypte (code pays fourni par la source)

Successful Pediatric Living Donor Liver Transplantation for Acute Liver Failure Due to Non‐transplant‐Related Severe Sinusoidal Obstruction Syndrome After Adjuvant Chemotherapy for Solid Organ Malignancy

Hiroki Hirao, Masaki Honda, Kaori Isono, Toru Goto et autres

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.

jp (code pays fourni par la source)

Intravital Imaging of Immune Responses in the Cancer Microenvironment

Hiroki Hirao, Masaki Honda, Masahiro Tomita, Lianbo Li et autres

BACKGROUND: To date, many types of immune cells have been identified, but their precise role in cancer immunity remains unclear. Understanding the immune responses involved in cancer and the cancer microenvironment is becoming increasingly important for elucidating disease mechanisms. In recent years, …

jp (code pays fourni par la source)

肝芽腫微小環境におけるSerpinB9の発現解析

Hiroki Hirao

The expression analysis of SerpinB9 in hepatoblastoma microenvironment

Hiroki Hirao, Ahmad Adawy, Lianbo Li, Daiki Yoshii et autres

jp, Égypte, cn (code pays fourni par la source)

Overexpression of SerpinB9 in non-seminomatous germ cell tumors

Toshiki Anami, Yuki Ibe, Lianbo Li, Yoshihiro Komohara et autres

jp (code pays fourni par la source)

Reappraisal of anatomical liver resection for hepatoblastoma in children

Masaki Honda, Kaori Isono, Kazuya Hirukawa, Masahiro Tomita et autres

Background: The principle of hepatoblastoma (HB) treatment is complete resection. The removal of tumor-bearing section(s) or hemiliver is widely accepted. However, neither the standardized anterior approach for right hepatectomy nor parenchymal sparing anatomical liver resection has been described for HB. Methods: We …

jp (code pays fourni par la source)

Potential involvement of IL-32 in cell-to-cell communication between macrophages and hepatoblastoma

Ahmad Adawy, Lianbo Li, Hiroki Hirao, Tomoaki Irie et autres

Égypte, jp, cn (code pays fourni par la source)