Wei Huang

Early-life tobacco smoke exposure and incident rheumatoid arthritis: mediated by allostatic load and joint effects with polygenic risk

Wei Huang, Xingyu Wan, Y. Wang, Yi-Han Hu et autres

OBJECTIVES: Rheumatoid arthritis (RA) is a widespread autoimmune disorder. Early-life environmental exposures may contribute to RA, and tobacco smoke represents an important modifiable factor. This study aimed to examine whether early-life tobacco smoke exposure affects incident RA risk, and to clarify the …

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Sex-driven differences in the rumen microbe-metabolite-epithelial transport axis: an integrated multi-omics study of rumen function in male and female Zhongwei goats

Wei Huang, Pengyang Shao, Qianling Chen, Yapeng He et autres

Sex is a critical regulatory factor affecting rumen microecology, substance metabolism, and epithelial transport function in ruminants. Nevertheless, potential molecular clues underlying sex‑associated differences of the ruminal microbe‑metabolite‑epithelial transport axis remain poorly understood. The present study aimed to elucidate the sex-specific regulatory …

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Integrated transcriptomic, proteomic, and metabolomic analyses characterize meat quality and flavor formation in Ziwuling Black Goats

Pengyang Shao, Qianling Chen, Juncheng Zhang, Wei Huang et autres

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Integrated mRNA-miRNA Transcriptome Analysis Reveals the Molecular Mechanism of Tibetan Sheep Rumen Epithelium Adaptation to High Altitude

Lei Wang, Wei Huang, Yuzhu Sha, Yanyu He et autres

The rumen epithelium of Tibetan sheep plays a critical role in energy metabolism and immune defense; however, its post-transcriptional regulatory mechanisms under high-altitude hypoxia stress remain unclear. In this study, we employed integrated mRNA and miRNA transcriptome sequencing to analyze the adaptive …

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Revealing the adaptive metabolic differences of different sheep breeds in plateau areas based on the Gut-Cardiac axis

Qianling Chen, Wenxin Yang, Yuzhu Sha, Xiu Liu et autres

Gut microbiota plays a significant role in maintaining the homeostasis of the gut internal environment, and the volatile fatty acids (VFAs) produced by it are the main source of energy utilization for the host. The cardiac, as a key metabolic organ of …

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Host EV–derived lipids promote malaria parasite development via mosquito fatty acid β-oxidation

Xiumei Song, Weimin Cai, Jiao Wu, Lijuan Liu et autres

Abstract Malaria parasites must transition between mammals and mosquitoes, but how they adapt to such distinct environments is unclear. We show that blood from infected mammals buffers this environmental shift by packaging parasite-induced signals into extracellular vesicles (EVs). EVs internalized by mosquito …

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Study on the Plateau Adaptive Synergistic Mechanism of Rumen Microbiome-Metabolome-Resistome in Tibetan Sheep

Qianling Chen, Yuzhu Sha, Yanyu He, Xiu Liu et autres

Tibetan sheep are an important livestock breed adapted to the extreme environment of the Qinghai–Tibet Plateau (QTP). Their energy metabolism and environmental adaptability are highly dependent on the rumen microbiome. However, systematic comparisons of the rumen microbiome, its functions, and the resistome …

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Interaction Between Rumen Microbiota and Epithelial Mitochondrial Dynamics in Tibetan Sheep: Elucidating the Mechanism of Rumen Epithelial Energy Metabolism

Ying Xu, Yuzhu Sha, Xiaowei Chen, Qianling Chen et autres

Investigating the functional interactions between rumen microbial fermentation and epithelial mitochondrial dynamics/energy metabolism in Tibetan sheep at different altitudes, this study examined ultrastructural changes in rumen epithelial tissues, expression levels of mitochondrial dynamics-related genes (fusion: Mfn1, Mfn2, OPA1, Mic60; fission: Drp1, Fis1, …

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A Study on the Differences in Rumen Microbiota–Liver Gluconeogenesis–Mitochondrial Interaction Between Tibetan Sheep and Hu Sheep in the Qinghai–Tibet Plateau

Qianling Chen, Yuzhu Sha, Xiu Liu, Min Gao et autres

As high-quality sheep germplasm resources in China, Hu sheep are characterized by fast growth and development, high fecundity, and tolerance to drought and cold. Tibetan sheep, adapted to high-altitude environments, have developed strong environmental adaptability. To explore the differences in the interaction …

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Host complement C3 promotes malaria transmission by killing symbiotic bacteria in the mosquito midgut

Biao He, Meilin Li, Feng Zhu, Zhiwei Jiao et autres

Host-derived factors ingested during mosquito blood feeding are poorly understood modulators of malaria transmission. Here, we demonstrated that host complement C3, acquired by mosquitoes during Plasmodium infection, significantly enhanced rodent malaria infection in laboratory-reared mosquitoes. This effect was recapitulated in field-caught Anopheles …

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The interaction between rumen microbiota and neurotransmitters plays an important role in the adaptation of phenological changes in Tibetan sheep

Wei Huang, Yuzhu Sha, Qianling Chen, Xiaowei Chen et autres

The gut-brain axis is regarded as the "second brain" of the host. Gut microbiota and their metabolites affect intestinal homeostasis, function, and phenotype by regulating bidirectional communication between the gut and brain. This serves as a vital strategy for understanding how gut …

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Leishmania sand fly-transmission is disrupted by Delftia tsuruhatensis TC1 bacteria

Pedro Cecílio, Luana Aparecida Rogerio, Tiago D. Serafim, Kristina Tang et autres

Most human pathogenic Leishmania species are zoonotic agents; therefore, sand fly-based control strategies are essential to prevent parasite circulation. Here, we used the Delftia tsuruhatensis TC1 strain, that inhibits the development of Plasmodium in mosquitoes, but in the context of Leishmania-infected sand …

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