Jiarong Xu

Local surgical trauma in the penile tunica albuginea of the rat: a new animal model of Peyronie's disease

Zitaiyu Li, Hongji Hu, Xiaoping Zheng, Biao Liu et autres

Background: Peyronie's disease (PD) is a relatively common clinical disorder of the penis that causes curvature and erectile dysfunction. However, the pathophysiological processes of PD are not well understood in current animal models and there exists limited clinical treatment options, which significantly …

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The critical role of PDGFRa + Sca1 + fibroblasts in angiogenesis and vascular repair in the corpus cavernosum

Biao Liu, Zitaiyu Li, Zhitao Han, Yuzhuo Chen et autres

BACKGROUND: Erectile dysfunction (ED) is an important cause of reduced quality of life for men and their partners. A common pathological feature across various types of ED, including diabetes mellitus-induced ED (DMED) and bilateral cavernous nerve injury-induced ED (CNIED), is the loss …

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Cadmium exposure induces Leydig cell injury via necroptosis caused by oxidative stress and TNF-α/TNFR1 signaling

Yaohui Sun, Jinhua Wang, Yinghao Yin, Zitaiyu Li et autres

Cadmium, a ubiquitous environmental pollutant, has been linked to testicular damage, primarily through mechanisms such as oxidative stress and various forms of programmed cell death. Despite extensive studies on its toxic effects, the specific role of necroptosis in cadmium-induced reproductive toxicity remains …

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Molecular and spatial signatures of human and rat corpus cavernosum physiopathological processes at single-cell resolution

Yinghao Yin, Yuzhuo Chen, Jiarong Xu, Biao Liu et autres

The composition and cellular heterogeneity of the corpus cavernosum (CC) microenvironment have been characterized, but the spatial heterogeneity at the molecular level remains unexplored. In this study, we integrate single-cell RNA sequencing (scRNA-seq) and spatial transcriptome sequencing to comprehensively chart the spatial …

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Low-grade elevation of palmitate and lipopolysaccharide synergistically induced β-cell damage via inhibition of neutral ceramidase

Yanan Xu, Zheng Wang, Shaokun Zhang, Jiarong Xu et autres

High concentrations of free fatty acids (FFAs) or lipopolysaccharide (LPS) could lead to β-cell apoptosis and dysfunction, while low-grade elevation of FFAs or LPS, which are more common in people with type 2 diabetes mellitus (T2DM) or obesity, have no obvious toxic …

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Lung protection of remote limb ischemic preconditioning after pulmonary resection

Maimaiti Tuerxunayi, Aimaiti Abulikemu, Ning Ma, Jiarong Xu et autres

Objective To evaluate lung protection of remote limb ischemic preconditioning after pulmonary resection. Methods Methods sixty adult patients scheduled for elective pulmonary resection, were randomly divided into control group(group C, 30 cases) and remote limb ischemic preconditioning(group RLIP, 30 cases) using a …

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Dysregulation of lncRNAs GM5524 and GM15645 involved in high‑glucose‑induced podocyte apoptosis and autophagy in diabetic nephropathy

Yamin Feng, Sheng Chen, Jiarong Xu, Qun Zhu et autres

Diabetic nephropathy (DN) is an important microvascular complication of diabetes, and one of the leading causes of end‑stage kidney disease. However, the mechanism of the DN pathogenic process remains unclear. Recently, long non‑coding (lnc)RNA dysregulation has been regarded to cause the occurrence …

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Prognostic value of SOX2, CyclinD1, P53, and ki-67 in patients with esophageal squamous cell carcinoma

Hui Wang, Yaxing Zhou, Qian Liu, Jiarong Xu et autres

Abstract: In this study, we evaluated SOX2 , Cyclin D1, p53, and ki-67 expression immunohistochemically in 117 samples of surgically resected esophageal squamous cell carcinoma (ESCC) and matched normal tumor adjacent tissues and correlated the expression with clinicopathological finding and patient survival. …

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Resveratrol protects podocytes against apoptosis via stimulation of autophagy in a mouse model of diabetic nephropathy

Shanshan Huang, Dafa Ding, Sheng Chen, Chenglong Dong et autres

Podocyte apoptosis coincides with albuminuria onset and precedes podocytopenia in diabetic nephropathy. However, there is a lack of effective therapeutic drugs to protect podocytes from apoptosis. Here, we demonstrated that resveratrol relieved a series of indicators of diabetic nephropathy and attenuated apoptosis …

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Relationship between serum bilirubin and serum C-peptide levels in patients with type 2 diabetes mellitus

Chenghui Yang, Jiarong Xu, You Na

The relationship between serum bilirubin and serum C-peptide levels in patients with type 2 diabetes mellitus was investigated. The clinical and laboratory data of 206 healthy subjects and 271 type 2 diabetic patients were collected. The partial correlation analysis and multiple linear …

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Heme oxygenase-1 enhances autophagy in podocytes as a protective mechanism against high glucose-induced apoptosis

Chenglong Dong, Haining Zheng, Shanshan Huang, You Na et autres

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[Impact of techniques for gastrointestinal tract reconstruction following gastrectomy on pancreatic β-cell function in patients with type 2 diabetes mellitus].

Jingli Cai, Baoqing Li, Chao Zheng, Xiaokun Lin et autres

OBJECTIVE: To evaluate the impact of different techniques for gastrointestinal tract reconstruction on postoperative pancreatic β-cell function in patients with type 2 diabetes mellitus (T2DM). METHODS: Twenty-three patients with gastric cancer and T2DM were studied. Techniques for reconstruction included Billroth I (n=13) …

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