2026
article
OpenAlex
Emma F. Shapiro, Clare McGillis, Gray H. Harlan, Zhi-Wei Lin et autres
Abstract We evaluated the performance of a new styrene-functionalized β-cyclodextrin (StyDex) bead formulation for removing a mixture of per- and polyfluoroalkyl substances (PFAS) and pharmaceuticals from municipal wastewater effluent using rapid small-scale column tests (RSSCTs) and a four month pilot study at …
ph, us
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2026
article
OpenAlex
Emma F. Shapiro, Zhi-Wei Lin, Gray H. Harlan, Disraëli Noami Marie-Theresse Kusmus et autres
Removal of trace organic contaminants (TrOCs) from wastewater is a major challenge, as existing technologies are nonselective and foul quickly in wastewater matrices. We used a rapid synthesis-screening approach to develop and test a range of styrene functionalized β-cyclodextrin (StyDex) bead formulations …
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2025
article
OpenAlex
Sheila L. Tran, Gray H. Harlan, David E Puckowitz, Nathan E Wohlstadter et autres
Within the field of mechanically interlocked molecules, catenanes have garnered much interest in the past few decades due to their chain-like architecture of interlocked molecular rings. This interest stems from their unique properties and degrees of freedom that are distinct in comparison …
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Accès ouvert
2024
article
OpenAlex
Gray H. Harlan, Sheila L. Tran, Nathan D. Colley, Mark A. Nosiglia et autres
Catenanes are a family of mechanically interlocked molecules that consist of molecular rings that can be interlocked to give linear, radial, or cyclic structures. Although chemists have pursued extended linear poly[n]catenane architectures for many decades, there still exists a fundamental gap between …
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Accès ouvert
2022
article
OpenAlex
Nathan D. Colley, Mark A. Nosiglia, Sheila L. Tran, Gray H. Harlan et autres
High Resolution Image Download MS PowerPoint Slide Catenanes are a well-known class of mechanically interlocked molecules that possess chain-like architectures and have been investigated for decades as molecular machines and switches. However, the synthesis of higher-order catenanes with multiple, linearly interlocked molecular …
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2022
article
OpenAlex
Mark A. Nosiglia, Nathan D. Colley, Mary K. Danielson, Mark S. Palmquist et autres
Mechanically interlocked molecules (MIMs) possess unique architectures and nontraditional degrees of freedom that arise from well-defined topologies that are achieved through precise mechanical bonding. Incorporation of MIMs into materials can thus provide an avenue to discover new and emergent macroscale properties. Here, …
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Accès ouvert
2021
preprint
OpenAlex
Mark A. Nosiglia, Nathan D. Colley, Mark S. Palmquist, Abigail O. Delawder et autres
Mechanically interlocked molecules (MIMs) possess unique architectures and non-traditional degrees of freedom that arise from well-defined topologies that are achieved through precise mechanical bonding. Incorporation of MIMs into materials can thus provide an avenue to discover new and emergent macroscale properties. Here, …
us
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Accès ouvert
2021
preprint
OpenAlex
Mark A. Nosiglia, Nathan D. Colley, Mark S. Palmquist, Abigail O. Delawder et autres
Mechanically interlocked molecules (MIMs) possess unique architectures and non-traditional degrees of freedom that arise from well-defined topologies that are achieved through precise mechanical bonding. Incorporation of MIMs into materials can thus provide an avenue to discover new and emergent macroscale properties. Here, …
us
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Accès ouvert
2021
article
OpenAlex
Hongbo Gao, Ayşe Naz Ozantürk, Qiankun Wang, Gray H. Harlan et autres
and humanized mouse models, we showed that the vpu/env assay could be used to measure antibody efficacy in clearing HIV-1 infection. These results suggest that the vpu/env assay can accurately evaluate HIV-1 reactivation and bNab-based therapeutic interventions.
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Accès ouvert
2021
article
OpenAlex
Qiankun Wang, Hongbo Gao, Kolin M. Clark, Christian Shema Mugisha et autres
Eradicating the last vestiges of HIV After treatment with antiretroviral therapy, HIV-1 wild-type and escape variants can persist in a latent form, especially within CD4 + T cells, hindering efforts to eradicate the virus. Q. Wang et al. found that human CARD8, …
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Accès ouvert
2020
preprint
OpenAlex
Qiankun Wang, Hongbo Gao, Kolin M. Clark, Tang Pengfei et autres
Abstract HIV-1 has high mutation rates and exists as mutant swarms in the host. Rapid evolution of HIV-1 allows the virus to outpace host immune system, leading to viral persistence. Novel approaches to target immutable components are needed to clear HIV-1 infection. …
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