Pavel Ovcharov

Multi-omic profiling of follicular lymphoma reveals changes in tissue architecture and enhanced stromal remodeling in high-risk patients

Andrea J. Radtke, Ekaterina Postovalova, Arina Varlamova, Alexander Bagaev et autres

us, de (code pays fourni par la source)

Spatial mapping of human hematopoiesis at single-cell resolution reveals aging-associated topographic remodeling

Aleksandr Sarachakov, Arina Varlamova, Viktor Svekolkin, Margarita Polyakova et autres

ABSTRACT: The spatial anatomy of hematopoiesis in the bone marrow (BM) has been extensively studied in mice and other preclinical models, but technical challenges have precluded a commensurate exploration in humans. Institutional pathology archives contain thousands of paraffinized BM core biopsy tissue …

us (code pays fourni par la source)

Single Cell Resolution Spatial Mapping of Human Hematopoiesis Reveals Aging-Associated Topographic Remodeling

Aleksandr Sarachakov, Arina Varlamova, Viktor Svekolkin, Ilia Galkin et autres

ABSTRACT The spatial anatomy of hematopoiesis in bone marrow has been extensively studied in mice and other preclinical models, but technical challenges have precluded a commensurate exploration in humans. Institutional pathology archives contain thousands of paraffinized bone marrow core biopsy tissue specimens, …

us (code pays fourni par la source)

Multiregional single-cell proteogenomic analysis of ccRCC reveals cytokine drivers of intratumor spatial heterogeneity

Natalia Miheecheva, Ekaterina Postovalova, Yang Lyu, Akshaya Ramachandran et autres

Intratumor heterogeneity (ITH) represents a major challenge for anticancer therapies. An integrated, multidimensional, multiregional approach dissecting ITH of the clear cell renal cell carcinoma (ccRCC) tumor microenvironment (TME) is employed at the single-cell level with mass cytometry (CyTOF), multiplex immunofluorescence (MxIF), and …

us (code pays fourni par la source)

Abstract 6151: Tumor microenvironment heterogeneity identifies potential biomarkers of response in ER-positive breast cancers treated with palbociclib

Maria Bruttan, Souzan Sanati, Anna Belozerova, Ilia Galkin et autres

Abstract Despite the breast cancer microenvironment being recognized as a critical participant in tumor progression and therapeutic response, current technologies for tumor cell-to-cell interaction analyses are limited to qualitative and descriptive histological methods. Here, we utilized multiplex immunofluorescence (MxIF), RNA sequencing (RNA-seq), …

us (code pays fourni par la source)

A Multi-scale, Multiomic Atlas of Human Normal and Follicular Lymphoma Lymph Nodes

Andrea J. Radtke, Ekaterina Postovalova, Arina Varlamova, Alexander Bagaev et autres

SUMMARY Reference atlases, molecular and spatial maps of mammalian tissues, are critical resources for discovery efforts and translational research. Their utility is dependent on operationalizing the resulting data by identifying cell types, histological patterns, and predictive biomarkers underlying health and disease. The …

us, de (code pays fourni par la source)

A clinical AI-driven multiplex immunofluorescence imaging pipeline to characterize tumor microenvironment heterogeneity.

Dmitry N. Zarubin, Valeriy Belotskiy, Zhongmin Xiang, Arina Varlamova et autres

3020 Background: Understanding the underlying heterogeneity of the tumor microenvironment (TME) on a single-cell level is becoming increasingly important to predict a patient’s response to immunotherapy. Conventional imaging methods can help reveal tissue heterogeneity, but are not optimal for identifying multiple cellular …

us (code pays fourni par la source)

Accompanying dataset for: A Multi-scale, Multiomic Atlas of Human Normal and Follicular Lymphoma Lymph Nodes

Andrea J. Radtke, Ekaterina Postovalova, Arina Varlamova, Alexander Bagaev et autres

This dataset accompanies the manuscript titled “A Multi-scale, Multiomic Atlas of Human Normal and Follicular Lymphoma Lymph Nodes”, A. Radtke et al., bioRxiv, 2022. [doi: 10.1101/2022.06.03.494716] The dataset contains comma-separated-value tables describing human lymph nodes, both normal and from Follicular Lymphoma (FL) …

us (code pays fourni par la source)

Accompanying dataset for: A Multi-scale, Multiomic Atlas of Human Normal and Follicular Lymphoma Lymph Nodes

Andrea J. Radtke, Ekaterina Postovalova, Arina Varlamova, Alexander Bagaev et autres

This dataset accompanies the manuscript titled “A Multi-scale, Multiomic Atlas of Human Normal and Follicular Lymphoma Lymph Nodes”, A. Radtke et al., bioRxiv, 2022. [doi: 10.1101/2022.06.03.494716] The dataset contains the processed scRNA-seq information from human lymph nodes, both normal and from Follicular …

us (code pays fourni par la source)

Accompanying dataset for: A Multi-scale, Multiomic Atlas of Human Normal and Follicular Lymphoma Lymph Nodes

Andrea J. Radtke, Ekaterina Postovalova, Arina Varlamova, Alexander Bagaev et autres

This dataset accompanies the manuscript titled “A Multi-scale, Multiomic Atlas of Human Normal and Follicular Lymphoma Lymph Nodes”, A. Radtke et al., bioRxiv, 2022. [doi: 10.1101/2022.06.03.494716] The dataset contains the processed scRNA-seq information from human lymph nodes, both normal and from Follicular …

us (code pays fourni par la source)

A Multi-Scale, Multiomic Atlas of Human Normal and Follicular Lymphoma Lymph Nodes

Andrea Radtke, Ekaterina Postovalova, Arina Varlamova, Alexander Bagaev et autres

us, de (code pays fourni par la source)

Topographic Analysis of Low-Grade Myeloid Neoplasms By Multiparametric in Situ Imaging of Human Bone Marrow Core Biopsy Tissues

Sanjay S. Patel, Viktor Svekolkin, Arina Varlamova, Ilia Galkin et autres

Abstract Diagnosis of low-grade myelodysplastic syndromes (LG-MDS) is one of the most challenging in hematopathology as it relies predominantly on morphologic assessment of dysplasia. Prior studies have demonstrated poor interobserver agreement among pathologists. Histomorphological evaluation of bone marrow core biopsy samples remains …

us (code pays fourni par la source)