Harnessing the novel safeguarding role of Selenoprotein T in age-related myocardial left and right decline through the ferroptosis-mitochondrial axis
Anna De Bartolo, Naomi Romeo, Lidia Urlandini, Vittoria Rago et autres
BACKGROUND: Cardiovascular aging critically increases myocardial susceptibility to ischemia/reperfusion (I/R) injury. Selenoprotein T (SELENOT) has emerged as a novel modulator of cardiomyocyte differentiation and protection. However, its involvement in chronic age-associated cardiac dysfunction is unknown. METHODS: Using a D-galactose ageing model in …
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Journal of Translational Medicine