Panagiotis Efentakis

Preclinical Evaluation of Berry Extracts as a Nutritional Intervention to Alleviate Myocardial Ischemia–Reperfusion Injury and Atherosclerosis Development

Lydia Symeonidi, Panagiota Nikolaou, Panagiotis Stathopoulos, Andriana Christodoulou et autres

ABSTRACT Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide. While studies suggest that berry fruits offer beneficial effects in CVD prevention, the bioactive compounds within different berries vary, and the specific mechanisms behind their protective effects are not …

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Correction: IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): a small animal acute myocardial infarction randomized-controlled multicenter study on the effect of ischemic preconditioning

Sauri Hernández‐Reséndiz, Reinis Vilšķe̅rsts, David Aluja, Ioanna Andreadou et autres

In the original article co-authors Gábor B. Brenner, András Makkos, Tamás G. Gergely and Nabil V. Sayour were missing from the author group due to an administrative error on the authors’ part. The authors contributed significantly to the study by generating all …

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Polycystin-1 as a Novel Biomarker for Peripheral Artery Disease: Findings from a Pilot Prospective Study

Theodoridis Pg, Spiros Georgopoulos, Chris N. Bakoyiannis, Konstantinos Davos et autres

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Challenges in the Investigation of Therapeutic Equivalence of Locally Applied/Locally Acting Drugs in the Gastrointestinal Tract: The Rifaximin Case

Georgia Tsakiridou, Panagiotis Efentakis, Maria Faidra Galini Angelerou, Lida Kalantzi

Background: Locally acting gastrointestinal (GI) drugs present challenges for generic drug development because traditional bioequivalence measures, which rely on systemic drug levels, do not reflect local efficacy. This review examines regulatory guidelines for establishing therapeutic equivalence for such drugs, using rifaximin—a minimally …

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Cardioprotection Through Pharmacological Activation of Sirtuin 5 in a Murine Model of Acute Myocardial Infarction

Carola Castiello, Panagiotis Efentakis, Panagiota Nikolaou, Lydia Symeonidi et autres

Purpose: Sirtuins (SIRTs) play a critical role in redox and metabolic regulation of the myocardium; however, the cardioprotective potential of SIRT5 in terms of infarct size (IS) reduction is still elusive. Herein, we employed the newly synthesized SIRT5-specific agonist, MC3215, developed by …

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IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): a small animal acute myocardial infarction randomized-controlled multicenter study on the effect of ischemic preconditioning

Sauri Hernández‐Reséndiz, Reinis Vilšķe̅rsts, David Aluja, Ioanna Andreadou et autres

Although many cardioprotective interventions have been shown to limit infarct size (IS), in preclinical animal studies of acute myocardial ischemia/reperfusion injury (IRI), their clinical translation to patient benefit has been largely disappointing. A major factor is the lack of rigor and reproducibility …

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Partial AUCs in Long-Acting Injectables: Rationale, Challenges, Variability, Usefulness, and Clinical Relevance

Georgia Tsakiridou, Maria-Faidra-Galini Angelerou, Panagiotis Efentakis, Antonios Margaritis et autres

Regulatory authorities typically require bioequivalence to be demonstrated by comparing pharmacokinetic parameters like area under the plasma concentration-time curve (AUC) and maximum plasma concentration (Cmax). Because in certain cases, AUC and Cmax alone may not be adequate to identify formulation differences in …

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Cardioprotective potential of oleuropein, hydroxytyrosol, oleocanthal and their combination: unravelling complementary effects on acute myocardial infarction and metabolic syndrome

A Christodoulou, Panagiota Nikolaou, Lydia Symeonidi, Konstantinos Katogiannis et autres

Abstract Background/Introduction Clinical studies have established the role of olive products in primary and secondary prevention of cardiovascular (CV) disease, but the single compounds or compound combinations responsible for the protective effects are still under investigation. Purpose We sought to explore and …

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Investigating the effect of chronic stress, depressive-like pathology and cognitive impairments on acute myocardial infarction: sex-differentiated effects

Christina Chania, Panagiota Nikolaou, Panagiotis Efentakis, Manousos Makridakis et autres

Abstract Background/Introduction Depression is an independent risk factor for cardiovascular disease (CVD) with the prevalence rates being higher in women than men in the general population and among patients with CVD. Furthermore, an association between myocardial infarction and cognitive deficits has been …

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Cardioprotective potential of oleuropein, hydroxytyrosol, oleocanthal and their combination: Unravelling complementary effects on acute myocardial infarction and metabolic syndrome

Andriana Christodoulou, Panagiota Nikolaou, Lydia Symeonidi, Konstantinos Katogiannis et autres

Clinical studies have previously established the role of olive products in cardiovascular disease (CVD) prevention, whilst the identification of the responsible constituents for the beneficial effects is still pending. We sought to assess and compare the cardioprotective potential of oleuropein (OL), hydroxytyrosol …

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Antihypertensive Potential of Pistacia lentiscus var. Chia: Molecular Insights and Therapeutic Implications

Panagiotis Efentakis, Lydia Symeonidi, Despoina D. Gianniou, Eleni V. Mikropoulou et autres

Background: Hypertension poses a significant global health burden and is associated with cardiovascular morbidity. Chios mastic gum (CMG), derived from Pistacia lentiscus var. Chia, shows potential as a phytotherapeutic agent, due to its multifaceted beneficial effects. However, its anti-hypertensive effects and vascular, …

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Myeloid cell-derived interleukin-6 induces vascular dysfunction and vascular and systemic inflammation

Tanja Knopp, Rebecca Jung, Johannes Wild, Magdalena L. Bochenek et autres

Abstract Aims The cytokine interleukin-6 (IL-6) plays a central role in the inflammation cascade as well as cardiovascular disease progression. Since myeloid cells are a primary source of IL-6 formation, we aimed to generate a mouse model to study the role of …

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