Accès ouvert
2026
article
OpenAlex
Zixuan Wang, Zhouxuan Ge, Haoyu Chao, Алибек Затыбеков et autres
Abiotic stress limits cereal productivity, yet whether conserved stress-responsive genes retain similar transcriptional network organization and cellular deployment across cereal species remains unknown. Here, we developed a machine learning-guided comparative framework to integrate public leaf transcriptomes of rice (Oryza sativa) and wheat …
cn, kz, id, ru
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Accès ouvert
2026
article
OpenAlex
Tatyana E. Kornienko, Arina A. Chepanova, Maria V. Kolobenko, Irina A. Chernyshova et autres
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a key enzyme for the repair of stalled topoisomerase 1 (TOP1)-DNA complexes. We previously developed a TDP1 inhibitor, compound OL9-116, which is capable of enhancing the action of the anticancer drug topotecan (TPC), a TOP1 poison, in …
ru
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
В. А. Иванисенко, T. M. Khlebodarova, M. A. Kleshchev, A. R. Volyanskaya et autres
An important direction in industrial microbiology is the development of probiotic strains with valuable consumer properties. The probiotic industry is currently one of the most rapidly developing segments of the food and pharmaceutical sectors. Stearic (octadecanoic) acid C18:0 is one of the …
ru
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Stefaniya O. Lebedeva, A. A. Makarova, Ekaterina A. Butikova, Nikita V. Basov et autres
Terahertz (THz) radiation is increasingly explored for biomedical applications, however, its non-thermal effects on cellular metabolism and regulatory networks remain insufficiently characterized. This study aimed to investigate how 2.3 THz radiation affects metabolic pathways and membrane-associated signaling in human melanoma cells.
ru
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
П. С. Деменков, Timofey Ivanisenko, В. А. Иванисенко
In modern bioinformatics, the analysis of high-dimensional data (genomic, metabolomic, etc.) remains a critical challenge due to the “curse of dimensionality,” where feature redundancy reduces classification efficiency and model interpretability. This study introduces a novel method, AIMarkerFinder (v0.1.0), for analyzing metabolomic data …
ru
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
П. С. Деменков, Timofey Ivanisenko, В. А. Иванисенко
Macrophages are immune system cells that perform various, often opposing, functions in the organism depending on the incoming microenvironment signals. This is possible due to the plasticity of macrophages, which allows them to radically alter their phenotypic characteristics and gene expression profiles, …
ru
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Accès ouvert
2025
article
OpenAlex
Nadezhda S. Dyrkheeva, Irina A. Chernyshova, Albert F. Arutyunyan, А. Л. Захаренко et autres
Oncological diseases remain a leading cause of pathological mortality worldwide, making the development of anticancer drugs a critical focus in medicinal chemistry. A promising strategy to enhance therapeutic efficacy and reduce chemotherapy-induced toxicity involves the combined inhibition of DNA repair enzymes and …
ru
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Nadezhda Levanova, Eugeny G. Vergunov, Alexander N. Savostyanov, В. А. Иванисенко
Accumulated evidence links dysregulated cytokine signaling to the pathogenesis of autism spectrum disorder (ASD), implicating genes, proteins, and their intermolecular networks. This paper systematizes these findings using bioinformatics analysis and machine learning methods. The primary tool employed in the study was the …
ru
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Accès ouvert
2025
preprint
OpenAlex
П. С. Деменков, Timofey Ivanisenko, В. А. Иванисенко
In modern bioinformatics, the analysis of high-dimensional data (genomic, metabolomic, etc.) remains a critical challenge due to the "curse of dimensionality," where feature redundancy reduces classification efficiency and model interpretability. This study introduces a novel method, AIMarkerFinder, for analyzing metabolomic data to …
ru
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
A. R. Volyanskaya, A. V. Adamovskaya, П. С. Деменков, Timofey Ivanisenko et autres
Although nitrogen fertilizers increase rice yield, their excess can impair plant resistance to diseases, particularly sheath blight caused by Rhizoctonia solani. This pathogen can destroy up to 50 % of the crop, but the mechanisms underlying reduced resistance under excess nitrogen remain …
ru, cn
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Accès ouvert
2025
article
OpenAlex
N. L. Podkolodnyy, O. A. Podkolodnaya, В. А. Иванисенко, М. А. Марченко
To systematize and effectively use the huge volume of experimental data accumulated in the field of bioinformatics and biomedicine, new approaches based on ontologies are needed, including automated methods for semantic integration of heterogeneous experimental data, methods for creating large knowledge bases …
ru
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
A. A. Makarova, P. M. Melnikova, Artem D. Rogachev, П. С. Деменков et autres
Parkinson's disease (PD) and vascular parkinsonism (VP) are characterized by similar neurological syndromes but differ in pathogenesis, morphology, and therapeutic approaches. The molecular genetic mechanisms of these pathologies are multifactorial and involve multiple biological processes. To comprehensively analyze the pathophysiology of PD …
ru
(code pays fourni par la source)