Amanda C. Hemmerich

Comparison of digital displays for efficient diagnosis and accuracy

Monika Lamba Saini, Amanda C. Hemmerich, Anna Banach-Ovens, Hannah Manssens et autres

Digital pathology is transforming diagnostic workflows by enabling the interpretation of whole-slide images on digital displays, offering advantages in remote diagnostics, efficiency, and integration with computational tools. However, diagnostic reliability depends not only on scanner and software quality but also on the …

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A Retrospective Genomic Landscape of 661 Young Adult Glioblastomas Diagnosed Using 2016 WHO Guidelines for Central Nervous System Tumors

James Haberberger, Worthy Pegram, Nicholas S. Britt, Kelsie Schiavone et autres

The authors present a cohort of 661 young adult glioblastomas diagnosed using 2016 WHO World Health Organization Classification of Tumors of the Central Nervous System, utilizing comprehensive genomic profiling (CGP) to explore their genomic landscape and assess their relationship to currently defined …

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Supplemental Data from Comprehensive Genomic Landscapes in Early and Later Onset Colorectal Cancer

Christopher Hanyoung Lieu, Erica A. Golemis, Ilya G. Serebriiskii, Justin Y. Newberg et autres

Supplemental Table 1 and Figures 1 and 2

Data from Comprehensive Genomic Landscapes in Early and Later Onset Colorectal Cancer

Christopher Hanyoung Lieu, Erica A. Golemis, Ilya G. Serebriiskii, Justin Y. Newberg et autres

AbstractPurpose: The incidence rates of colorectal cancers are increasing in young adults. The objective of this study was to investigate genomic differences between tumor samples collected from younger and older patients with colorectal cancer. Experimental Design: DNA was extracted from 18,218 clinical …

Data from Comprehensive Genomic Landscapes in Early and Later Onset Colorectal Cancer

Christopher Hanyoung Lieu, Erica A. Golemis, Ilya G. Serebriiskii, Justin Y. Newberg et autres

AbstractPurpose: The incidence rates of colorectal cancers are increasing in young adults. The objective of this study was to investigate genomic differences between tumor samples collected from younger and older patients with colorectal cancer. Experimental Design: DNA was extracted from 18,218 clinical …

Supplemental Data from Comprehensive Genomic Landscapes in Early and Later Onset Colorectal Cancer

Christopher Hanyoung Lieu, Erica A. Golemis, Ilya G. Serebriiskii, Justin Y. Newberg et autres

Supplemental Table 1 and Figures 1 and 2

Genomic Profiling Reveals Differences in Primary Central Nervous System Lymphoma and Large B-Cell Lymphoma, With Subtyping Suggesting Sensitivity to BTK Inhibition

Eric Allan Severson, James Haberberger, Amanda C. Hemmerich, Richard S.P. Huang et autres

BACKGROUND: B-cell primary central nervous system (CNS) lymphoma (PCL) is diffuse large B-cell lymphoma (DLBCL) confined to the CNS. Less than 50% of patients with PCL achieve complete remission with current therapies. We describe the findings from comprehensive genomic profiling (CGP) of …

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A Case Series of Metastatic Malignant Gastrointestinal Neuroectodermal Tumors and Comprehensive Genomic Profiling Analysis of 20 Cases

Taylor Kandler, Eliane Cortez, Lani Kai Clinton, Amanda C. Hemmerich et autres

Malignant gastrointestinal neuroectodermal tumor (GNET) is an ultra-rare soft tissue sarcoma, therefore often misdiagnosed and has no available standard treatment. Here, we report 3 cases of metastatic GNET with variable clinical courses. Our small case series as well as extensive literature review, …

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Comprehensive genomic profiling of histologic subtypes of urethral carcinomas

Joseph M Jacob, Andrea Necchi, Petros D. Grivas, Michael M. Hughes et autres

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Landscape of Biomarkers in Non-small Cell Lung Cancer Using Comprehensive Genomic Profiling and PD-L1 Immunohistochemistry

Richard S.P. Huang, Eric Allan Severson, James Haberberger, Daniel L. Duncan et autres

Comprehensive genomic profiling (CGP) and immunohistochemistry (IHC) are important biomarker tools used for patients with non-small cell lung cancer (NSCLC) given the expanding number of standard-of-care therapies that require companion diagnostic testing. We examined 9450 NSCLC real-world patient samples that underwent both …

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Clinicopathologic and Genomic Characterization of PD-L1 Positive Urothelial Carcinomas

Richard S.P. Huang, James Haberberger, Lukas Harries, Eric Allan Severson et autres

Abstract Introduction Pembrolizumab was approved with an accompanying companion diagnostic (CDx) assay (PD-L1 DAKO 22C3) for urothelial carcinoma (UC). In this study, we further characterize the clinicopathologic and genomic features of UC that are programmed death-ligand 1 (PD-L1) positive. Materials and Methods …

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In search of novel synthetic lethality anti-cancer drug targets in intrahepatic cholangiocarcinoma: MTAP genomic loss.

Jeffrey S. Ross, Alexa Betzig Schrock, Russell William Madison, Natalie A. Danziger et autres

337 Background: The association of BRCA tumor suppressor gene (TSG) inactivation and PARP inhibitor efficacy through a mechanism of synthetic lethality (SL) is now well-established. Recently, the PRMT5 arginine methyltransferase dependence in cells with MTAP (S-methyl-5'-thioadenosine phosphorylase) genomic alterations (GA) has been …