Maria Vitória Gomes das Neves

In silico and in vitro investigation of the safety and immunomodulatory mechanisms of 7-hydroxyflavone

Vanessa da Silva Oliveira, Dahara Keyse Carvalho Silva, Maria Vitória Gomes das Neves, Sérgio Santos Silva et autres

7-Hydroxyflavone (7HF) is a natural flavonoid with recognized antioxidant and anti-inflammatory properties, but its immunomodulatory potential and underlying molecular mechanisms remain poorly defined. This study investigated the immunomodulatory activity of 7HF in human peripheral blood mononuclear cells (PBMCs) and murine splenocytes through …

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Ruthenium Complexes Containing Thiobenzamide Act as Potent and Selective Anti- Trypanosoma cruzi Agents through Apoptotic Cell Death

Maria Vitória Gomes das Neves, Isabela Santos Cezar, Edivaldo dos Santos Rodrigues, Felipe Cardoso Teixeira Bomfim et autres

High Resolution Image Download MS PowerPoint Slide Chagas disease remains a significant global health concern, with current therapies limited to benznidazole and nifurtimox, which have adverse effects and show reduced efficacy in the chronic phase. This study investigated ruthenium complexes with or …

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Alterations in Cardiac Metabolism by Trypanosoma cruzi Infection: A Metabolomic Assessment by RPLC-MS and GC–MS

Hanna Carvalho de Sá, Breno Cardim Barreto, Maria Vitória Gomes das Neves, Maria Carolina dos Santos et autres

, has been one of the leading causes of cardiac death in Latin America. Its pathogenesis and progression are still poorly understood. Thus, we performed an untargeted metabolomics analysis to understand the metabolic changes involved in the final acute phase of CD. …

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In silico, in vitro, and in vivo assessment of anti-Trypanosoma cruzi activity of the 1H-indazole-containing ruthenium complex FOR0E2

Isabela Santos Cezar, Maria Vitória Gomes das Neves, Jaqueline Wang da Silva, Ivanilson Pimenta Santos et autres

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Phenanthroline and hydroxyurea-based Co( iii ) complexes: synthesis, characterization and investigation of biological potential

Gabriela Cruz Fernandes, Lourdes Cardoso de Souza Neta, Maria Vitória Gomes das Neves, Isabela Santos Cezar et autres

It is undeniable that society has made significant advances in developing products and technologies to treat and remedy various diseases affecting the population.

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The effects of inflammation on connexin 43 in chronic Chagas disease cardiomyopathy

Breno Cardim Barreto, Maria Vitória Gomes das Neves, Carine Machado Azevedo Cardoso, Cássio Santana Meira et autres

Background Cardiac arrhythmias are the main cause of sudden death due to Chronic Chagasic Cardiomyopathy (CCC). Here we investigated alterations in connexin 43 (Cx43) expression and phosphorylation in cardiomyocytes as well as associations with cardiac arrhythmias in CCC. Methods C57Bl/6 mice infected …

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Prevalência da síndrome de burnout e fatores associados em biomédicos atuantes na região metropolitana de Salvador, BA

Isabela Santos Cezar, Catia Virgens Santos, Maria Vitória Gomes das Neves, Jéssica Santos Dias de Abreu et autres

Introdução: A síndrome de Burnout (SB) é um fenômeno caracterizado pelo esgotamento emocional crônico que pode gerar consequências físicas e psíquicas. A presença da SB é relatada em diversos profissionais da área de saúde. Contudo, a literatura carece de trabalhos que investiguem …

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Anti-Inflammatory Activities of Betulinic Acid: A Review

José Fernando Oliveira Costa, Cássio Santana Meira, Maria Vitória Gomes das Neves, Bruna Padilha Zurita Claro dos Reis et autres

Inflammatory diseases have a high prevalence and has become of great interest due to the increase in life expectancy and the costs to the health care system worldwide. Chronic diseases require long-term treatment frequently using corticosteroids and non-steroidal anti-inflammatory drugs, which are …

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Resistência adquirida por Enterobactérias ao tratamento por aminoglicosídeos no Brasil uma revisão sistemática da literatura

Thassila Nogueira Pitanga, Ícaro Ströbel Morais, Daniella Teixeira de Castro Cunha, Maria Vitória Gomes das Neves et autres

As enterobacterias sao microrganismos que constituem a microbiota intestinal humana, podendo causar inumeras infeccoes. Geralmente, a primeira escolha para o tratamento de infeccoes causadas por esses patogenos sao os farmacos da classe dos aminoglicosideos. Esses farmacos atuam promovendo a inibicao da sintese …