Yinzhi Lin

Distinct and compensatory roles of STAG1 and STAG2 in post-mitotic genome refolding

Manzhu Wang, Fengnian Shan, Fuhai Liu, Sijian Xia et autres

Abstract The three-dimensional architecture of the eukaryotic genome is largely shaped by the cohesin complex, which contains either Stag1 or Stag2 subunits. Although both subunits contribute to chromatin organization, their specific functions in de novo loop formation during post-mitotic genome refolding remain …

cn, us, hk, np (code pays fourni par la source)

Nintedanib inhibits the VEGFR–ERK signaling pathway in human KRAS-mutated cancer cells

Sivasundaram Karnan, Akinobu Ota, Muhammad Nazmul Hasan, Toshinori Hyodo et autres

Abstract KRAS mutations are significant drivers in various cancers, and existing drug discovery attempts targeting these mutations have largely been unsuccessful, emphasizing the need for more effective therapies. In this study, the screening library, which contains 1,374 chemical compounds, identified nintedanib, a …

jp, bd, us (code pays fourni par la source)

Supplementary Video 1 from Ciliated Cells Drive Critical STING-Mediated Tumor Suppression in the Fallopian Tube Epithelium

Jose A. Colina, María Sol Recouvreux, Alexander M. Sobeck, Benjamin K. Johnson et autres

Oviductal organoids from STING-/- mice retained secretory and ciliated cell populations (video showing cilia beating)

Supplementary Table 1 from Ciliated Cells Drive Critical STING-Mediated Tumor Suppression in the Fallopian Tube Epithelium

Jose A. Colina, María Sol Recouvreux, Alexander M. Sobeck, Benjamin K. Johnson et autres

Human IHC antibodies used to stain normal, precursor, and ovarian tumors

Supplementary Figure 2 from Ciliated Cells Drive Critical STING-Mediated Tumor Suppression in the Fallopian Tube Epithelium

Jose A. Colina, María Sol Recouvreux, Alexander M. Sobeck, Benjamin K. Johnson et autres

STING1 expression is most highly expressed in ciliated cells of the FTE

Supplementary Video 2 from Ciliated Cells Drive Critical STING-Mediated Tumor Suppression in the Fallopian Tube Epithelium

Jose A. Colina, María Sol Recouvreux, Alexander M. Sobeck, Benjamin K. Johnson et autres

Oviductal organoids from wildtype mice retained secretory and ciliated cell populations (video showing cilia beating)

Supplementary Table 3 from Ciliated Cells Drive Critical STING-Mediated Tumor Suppression in the Fallopian Tube Epithelium

Jose A. Colina, María Sol Recouvreux, Alexander M. Sobeck, Benjamin K. Johnson et autres

Western blot antibodies

Supplementary Figure 7 from Ciliated Cells Drive Critical STING-Mediated Tumor Suppression in the Fallopian Tube Epithelium

Jose A. Colina, María Sol Recouvreux, Alexander M. Sobeck, Benjamin K. Johnson et autres

STING activation promotes paracrine signaling that amplifies stress responses in neighboring cells

Supplementary Figure 8 from Ciliated Cells Drive Critical STING-Mediated Tumor Suppression in the Fallopian Tube Epithelium

Jose A. Colina, María Sol Recouvreux, Alexander M. Sobeck, Benjamin K. Johnson et autres

p53 integrity modulates stress-induced signaling downstream of oxidative damage

Supplementary Table 8 from Ciliated Cells Drive Critical STING-Mediated Tumor Suppression in the Fallopian Tube Epithelium

Jose A. Colina, María Sol Recouvreux, Alexander M. Sobeck, Benjamin K. Johnson et autres

Quantification of IHC staining for STING conducted on a tumor microarray including cores from healthy FT, FT from patients with gynecological inflammation resulting from endometriosis or chronic salpingitis, and Stage I/Stage II HGSC

Data from Ciliated Cells Drive Critical STING-Mediated Tumor Suppression in the Fallopian Tube Epithelium

Jose A. Colina, María Sol Recouvreux, Alexander M. Sobeck, Benjamin K. Johnson et autres

Abstract Mitigating DNA damage in the fallopian tube epithelium (FTE) is essential for preventing tubo-ovarian high-grade serous carcinoma (HGSC). In this study, we demonstrated that the stimulator of interferon genes (STING) is abundantly expressed in the ciliated cells of the FTE and …

Supplementary Figure 1 from Ciliated Cells Drive Critical STING-Mediated Tumor Suppression in the Fallopian Tube Epithelium

Jose A. Colina, María Sol Recouvreux, Alexander M. Sobeck, Benjamin K. Johnson et autres

Multiplex IHC staining on a tumor microarray containing normal FTE and various stage HGSC samples