Michael J. Gregory

Little evidence of cardiac involvement in Mild and Moderate Swimming- Induced Pulmonary Oedema (SIPE)

Anniina Lindqvist, Doug Hacking, Leah Wright, Brian Cowie et autres

au, us (code pays fourni par la source)

High incidence of multidrug-resistant organisms and modifiable risk factors associated with surgical site infections: a cohort study in a tertiary medical center in Kuala Lumpur, Malaysia from 2020 to 2023

Anis Najwa Muhamad, Cindy Shuan Ju Teh, Mohd Rusdi Draman Yusof, Yohan Khirusman Adnan et autres

BACKGROUND: Surgical site infections (SSIs) are a persistent challenge in healthcare, contributing significantly to patient morbidity, mortality, and healthcare costs. Despite advancements in preventive measures, SSIs remain prevalent, especially in countries like Malaysia where rates are higher than in high-income nations. METHODS: …

my, kh (code pays fourni par la source)

Etiology and risk factors for diarrheal disease amongst rural and peri-urban populations in Cambodia, 2012–2018

Gerard C. Kelly, Agus Rachmat, Robert D. Hontz, Marvin J. Sklar et autres

Diarrheal diseases are a leading cause of mortality and morbidity, disproportionally affecting persons residing in low and middle-income countries. Accessing high-resolution surveillance data to understand community-level etiology and risk remains challenging, particularly in remote and resource limited populations. A multi-year prospective cohort …

kh (code pays fourni par la source)

Leptospirosis infections among hospital patients, Sarawak, Malaysia

King-Ching Hii, Emily Robie, Izreena Saihidi, Antoinette Berita et autres

BACKGROUND: Leptospirosis diagnoses have increased in Sarawak, Malaysia in recent years. METHODS: To better understand the burden of disease and associated risk factors, we evaluated 147 patients presenting with clinical leptospirosis to local hospitals in Sarawak, Malaysia for the presence of Leptospira …

my, us, cn, sg (code pays fourni par la source)

Evaluation of the Immunogenicity and Protective Efficacy of an Enterotoxigenic Escherichia coli CFA/I Adhesin–Heat-Labile Toxin Chimera

Aisling O’Dowd, Milton Maciel, S. Poole, Michael G. Jobling et autres

Recent efforts to develop an enterotoxigenic Escherichia coli (ETEC) vaccine have focused on the antigenically conserved tip adhesins of colonization factors. We showed previously that intranasal immunization with dsc 19 CfaE, a soluble variant of the in cis donor strand-complemented tip adhesin …

us, pe (code pays fourni par la source)

Tracking Antimicrobial Resistance Determinants in Diarrheal Pathogens: A Cross-Institutional Pilot Study

Chris R. Taitt, Tomasz A. Łęski, Michael G. Prouty, Gavin W. Ford et autres

Infectious diarrhea affects over four billion individuals annually and causes over a million deaths each year. Though not typically prescribed for treatment of uncomplicated diarrheal disease, antimicrobials serve as a critical part of the armamentarium used to treat severe or persistent cases. …

us, kh, pe, Kenya (code pays fourni par la source)

An Observational Study of Sepsis in Takeo Province Cambodia: An in-depth examination of pathogens causing severe infections

Michelle Rozo, Kevin L. Schully, Casandra Philipson, Amitha Fitkariwala et autres

The world's most consequential pathogens occur in regions with the fewest diagnostic resources, leaving the true burden of these diseases largely under-represented. During a prospective observational study of sepsis in Takeo Province Cambodia, we enrolled 200 patients over an 18-month period. By …

us, kh (code pays fourni par la source)

Distribution of Capsular Types of Campylobacter jejuni Isolates from Symptomatic and Asymptomatic Children in Peru

Jesús Rojas, Nathanael D. Reynolds, Brian L. Pike, Nereyda Espinoza et autres

Campylobacter jejuni is the leading bacterial cause of diarrhea worldwide. A capsular polysaccharide (CPS) conjugate vaccine is under development and requires determination of the valency. However, distribution of CPS types circulating globally is presently poorly described. We aimed to determine whether CPS …

pe, us (code pays fourni par la source)

Evaluating the discriminating capacity of cell death (apoptotic) biomarkers in sepsis

Christopher Duplessis, Michael J. Gregory, Kenneth G. Frey, Matthew Bell et autres

BACKGROUND: Sepsis biomarker panels that provide diagnostic and prognostic discrimination in sepsis patients would be transformative to patient care. We assessed the mortality prediction and diagnostic discriminatory accuracy of two biomarkers reflective of cell death (apoptosis), circulating cell-free DNA (cfDNA), and nucleosomes. …

us (code pays fourni par la source)

The other Campylobacters: Not innocent bystanders in endemic diarrhea and dysentery in children in low-income settings

Ruthly François, Pablo Peñataro Yori, Saba Rouhani, Mery Siguas Salas et autres

BACKGROUND: Campylobacter is one of the main causes of gastroenteritis worldwide. Most of the current knowledge about the epidemiology of this food-borne infection concerns two species, C. coli and C. jejuni. Recent studies conducted in developing countries and using novel diagnostic techniques …

us, pe (code pays fourni par la source)

Melioidosis in lower provincial Cambodia: A case series from a prospective study of sepsis in Takeo Province

Kevin L. Schully, Catherine M Berjohn, Angela M. Prouty, Amitha Fitkariwala et autres

Melioidosis is a severe infectious disease caused by the gram-negative soil bacterium Burkholderia pseudomallei. Melioidosis is well known to be a major cause of morbidity and mortality in Southeast Asia, particularly in Thailand. However, melioidosis remains underreported in surrounding areas such as …

us, kh (code pays fourni par la source)

De novo identification of VRC01 class HIV-1–neutralizing antibodies by next-generation sequencing of B-cell transcripts

Jiang Zhu, Xueling Wu, Baoshan Zhang, Krisha McKee et autres

Next-generation sequencing of antibody transcripts provides a wealth of data, but the ability to identify function-specific antibodies solely on the basis of sequence has remained elusive. We previously characterized the VRC01 class of antibodies, which target the CD4-binding site on gp120, appear …

us, ca (code pays fourni par la source)