Marcylene Vieira da Silveira

Effects of Bioactive Microalgal Pigment Intake on Metabolic Parameters, Cecal Distribution and Short-Chain Fatty Acids in a Diabetic Rat Model

Patrícia Acosta Caetano, Tatiele C. do Nascimento, Marcylene Vieira da Silveira, Duane Soares Vieira et autres

Type 2 diabetes mellitus (T2DM) represents a major global public health challenge, and bioactive compounds have been investigated as complementary nutritional strategies for disease management. This study evaluated, for the first time, the effects of carotenoids and chlorophylls (lipophilic extract) of Scenedesmus …

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Resveratrol as a potential natural compound to ameliorate cognitive impairment in aluminum-exposed mice: impacts on behavior, purinergic system, and brain inflammation

Arrigo Visentini, Karine Paula Reichert, Maria Rosa Chitolina Schetinger, Nathieli Bianchin Bottari et autres

Aluminum (Al³⁺) accumulates in the brain and has been linked to neurodegeneration. When combined with citrate, its absorption increase, raising the risk of neurodegenerative disorders such as Alzheimer’s disease. Resveratrol (RSV), a polyphenol with anti-inflammatory, antioxidant, and neuroprotective properties, has been associated …

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Capsaicin suppresses LPS-induced inflammatory responses via NLRP3/CASP-1/IL-1β axis and purinergic pathways in BV-2 microglial cells

Bianca Vedoin Copês Rambo, Milagros Fanny Vera Castro, Mairin Schott, Robson Lourenço da Silva Santos et autres

Abstract Microglial activation drives neuroinflammation, a key factor in many neurological diseases. The purinergic system is a major regulator of inflammatory responses and represents a promising target for controlling neuroinflammation. Capsaicin, a bioactive compound found in chili peppers, exhibits significant anti-inflammatory and …

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Cytotoxic and immunotoxic profile of HgCl2 involves alterations in purinergic signaling through the P2X7/NLRP3/CASP-1/IL-1β pathway: An in vitro study using human blood immune cells

Mairin Schott, Charles Elias Assmann, Bianca Vedoin Copês Rambo, Marcylene Vieira da Silveira et autres

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Quercetin and Tranylcypromine Improve Memory, Behavioral Performance, and Cholinergic Function in Male Rats Subjected to Chronic Restraint Stress

Vitor Bastianello Mostardeiro, Charles Elias Assmann, Adriel Antônio Schirmann, Marcylene Vieira da Silveira et autres

Background/Objectives: Major depressive disorder (MDD) is a debilitating illness, and chronic stress is a contributing factor for depressive symptoms. However, despite intense research, the mechanisms of MDD remain substantially unidentified. Quercetin is a powerful flavonoid and could be used as a possible …

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Resveratrol Alleviates Inflammatory Response Through P2X7/NLRP3 Signaling Pathway: In Silico and In Vitro Evidence from Activated Microglia

Bianca Fagan Bissacotti, Marcylene Vieira da Silveira, Charles Elias Assmann, Priscila Marquezan Copetti et autres

Background/Objectives: Chronic inflammation and inappropriate NLRP3 inflammasome regulation are related to many brain diseases. Purinergic mediators may play an important role in inflammation regulation and could be targeted for effective therapies for these illnesses. We evaluated resveratrol’s anti-neuroinflammatory potential in BV-2 microglia …

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The Cecal Distribution of Microalgal Pigments in Rats: Do Carotenoids and Chlorophylls Play a Pharmacobiotic Role?

Tatiele Casagrande do Nascimento, Patrícia Acosta Caetano, Marcylene Vieira da Silveira, Luiz Eduardo Lobo e Silva et autres

This study investigated the cecal distribution of lipophilic pigments (carotenoids and chlorophylls) from Scenedesmus obliquus and their effects on the activity of the intestinal microbiota in rats. Oleoresins containing different concentrations of microalgal pigments (from 0 to 600 µg·kg−1bw·d−1), previously characterized by …

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Inclusion of yeast and saccharides based-product to replace monensin in the diet of confined steers: performance, rumen environment, metabolism, animal health, and meat quality

Luísa Nora, Guilherme Luiz Deolindo, Mateus Henrique Signor, Andrei Lucas Rebelatto Brunetto et autres

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Dehydrated natural feed for dogs: influence on digestibility, immunity, and antioxidant response

Bruno Giorgio de Oliveira Cécere, Emerson Zatti, Bianca Fagan Bissacotti, Priscila Marquezan Copetti et autres

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Microalgae-Derived Carotenoid Extract and Biomass Reduce Viability, Induce Oxidative Stress, and Modulate the Purinergic System in Two Melanoma Cell Lines

Luísa Chitolina Schetinger, Loren S. B. de Jesus, Nathieli Bianchin Bottari, Altevir Rossato Viana et autres

Cutaneous melanoma (CM) is an aggressive and metastatic tumor, resulting in high mortality rates. Despite significant advances in therapeutics, the available treatments still require improvements. Thus, purinergic signaling emerged as a potential pathway to cancer therapy due to its involvement in cell …

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Neuroprotective effect of long‐term resistance physical exercise against memory damage elicited by a lipopolysaccharide‐induced neuroinflammation model in male rats

Vanessa Valéria Miron, Charles Elias Assmann, Vitor Bastianello Mostardeiro, Marcylene Vieira da Silveira et autres

Resistance exercise training (RET) is considered an excellent tool for preventing diseases with an inflammatory background. Its neuroprotective, antioxidant, and anti-inflammatory properties are responsible for positively modulating cholinergic and oxidative systems, promoting neurogenesis, and improving memory. However, the mechanisms behind these actions …

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Vanessa Valéria Miron, Charles Elias Assmann, Vitor Bastianello Mostardeiro, Marcylene Vieira da Silveira et autres