Accès ouvert
2024
article
OpenAlex
Kathryn L. Shelley, Elspeth F. Garman
Radiation damage remains one of the major impediments to accurate structure solution in macromolecular crystallography. The artefacts of radiation damage can manifest as structural changes that result in incorrect biological interpretations being drawn from a model, they can reduce the resolution to …
us, gb
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Jon Agirre, Mihaela Atanasova, Haroldas Bagdonas, Charles B. Ballard et autres
The Collaborative Computational Project No. 4 (CCP4) is a UK-led international collective with a mission to develop, test, distribute and promote software for macromolecular crystallography. The CCP4 suite is a multiplatform collection of programs brought together by familiar execution routines, a set …
gb, br, fr, es, de, au, nl, cz, se, ch, us, it
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Amy Thomas, Elizabeth Oliver, Holly E. Baum, Kapil Gupta et autres
BACKGROUND: Saliva is easily obtainable non-invasively and potentially suitable for detecting both current and previous SARS-CoV-2 infection, but there is limited evidence on the utility of salivary antibody testing for community surveillance. METHODS: We established 6 ELISAs detecting IgA and IgG antibodies …
gb, pt
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
William Dawson, Kathryn L. Shelley, Jordan M. Fletcher, D. Arne Scott et autres
Differential sensing attempts to mimic the mammalian senses of smell and taste to identify analytes and complex mixtures. In place of hundreds of complex, membrane-bound G-protein coupled receptors, differential sensors employ arrays of small molecules. Here we show that arrays of computationally …
gb, de, us
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Alice Halliday, Anna E. Long, Holly E. Baum, Amy Thomas et autres
Low-volume antibody assays can be used to track SARS-CoV-2 infection rates in settings where active testing for virus is limited and remote sampling is optimal. We developed 12 ELISAs detecting total or antibody isotypes to SARS-CoV-2 nucleocapsid, spike protein or its receptor …
gb, it
(code pays fourni par la source)
Accès ouvert
2022
preprint
OpenAlex
Alice Halliday, Anna E. Long, Holly E. Baum, Amy Thomas et autres
Abstract Low-volume antibody assays can be used to track SARS-CoV-2 infection rates in settings where active testing for virus is limited and remote sampling is optimal. We developed 12 ELISAs detecting total or antibody isotypes to SARS-CoV-2 nucleocapsid, spike protein or its …
gb, it
(code pays fourni par la source)
Accès ouvert
2022
preprint
OpenAlex
Amy Thomas, Elizabeth Oliver, Holly E. Baum, Kapil Gupta et autres
Abstract Saliva is easily obtainable non-invasively and potentially suitable for detecting both current and previous SARS-CoV-2 infection. We established 6 standardised enzyme linked immunosorbent assays (ELISA) capable of detecting IgA and IgG antibodies to whole SARS-CoV-2 spike protein, to its receptor binding …
gb, pt
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Kathryn L. Shelley, Elspeth F. Garman
Abstract Radiation damage remains one of the major bottlenecks to accurate structure solution in protein crystallography. It can induce structural and chemical changes in protein crystals, and is hence an important consideration when assessing the quality and biological veracity of crystal structures …
gb
(code pays fourni par la source)
Accès ouvert
2021
dataset
OpenAlex
Kathryn L. Shelley, Elspeth F. Garman
Dataset comparing five different skewness metrics (including the Bnet metric) across 23 radiation damage datasets in the publication "Quantifying and comparing radiation damage in the Protein Data Bank"
gb
(code pays fourni par la source)
Accès ouvert
2021
dataset
OpenAlex
Kathryn L. Shelley, Elspeth F. Garman
Dataset comparing five different skewness metrics (including the Bnet metric) across 23 radiation damage datasets in the publication "Quantifying and comparing radiation damage in the Protein Data Bank"
gb
(code pays fourni par la source)
2021
article
OpenAlex
Kathryn L. Shelley, Elspeth F. Garman
During macromolecular crystallography (MX) data collection one or more crystals are exposed to a high flux of ionising radiation, which even at cryo-temperatures can damage the crystal(s), causing structural and chemical changes.If sufficiently severe, this damage can prevent solution of the crystal …
gb
(code pays fourni par la source)
Accès ouvert
2021
dataset
OpenAlex
Kathryn L. Shelley, Elspeth F. Garman
Dataset of Bnet values, plus associated metadata (resolution, Rwork, Rfree, temperature, etc.), for 23 radiation damage series deposited in the PDB that are analysed in the publication "Quantifying and comparing radiation damage in the Protein Data Bank"
gb
(code pays fourni par la source)