Robin Sebastian

Lamin A/C loss promotes R-loop-mediated genomic instability and poor survival in small-cell lung cancer

Christopher W. Schultz, Sourav Saha, Anjali Dhall, Yang Zhang et autres

Lamin A/C ( LMNA ), a key component of the nuclear envelope, is essential for maintaining nuclear integrity and genome organization [W. Xie et al. , Curr. Biol. 26 , 2651–2658 (2016)]. While LMNA dysregulation has been implicated in genomic instability across …

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NOTCH1 reverses immune suppression in small cell lung cancer through reactivation of STING

Yoo Sun Kim, Barzin Y. Nabet, Briana Cortez, Nai-Yun Sun et autres

Downregulation of antigen presentation and lack of immune infiltration are defining features of small cell lung cancer (SCLC), limiting response to immune checkpoint blockade (ICB). While a high-MHC class I, immune-inflamed subset benefits from ICB, underlying mechanisms of immune response in SCLC …

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Selective interactions at pre-replication complexes categorize baseline and dormant origins

Bhushan Thakur, Christophe E. Redon, Haiqing Fu, Robin Sebastian et autres

DNA synthesis in metazoans initiates within a select group of replication origins (baseline origins), whereas other (dormant) origins do not initiate replication despite recruiting apparently indistinguishable pre-replication complexes. Dormant origins are activated as backups when DNA synthesis stalls, allowing for complete genome …

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Abstract 6404: NOTCH1 drives immunogenicity through STING and improves survival with immune checkpoint blockade in small cell lung cancer

Yoo Sun Kim, Barzin Y. Nabet, Briana N. Cortez, Nai-Yun Sun et autres

Abstract Immune checkpoint blockade (ICB) combined with chemotherapy as a first-line treatment for extensive-stage small-cell lung cancer (ES-SCLC) has shown modest survival benefits. While a subset of patients with immune-inflamed tumors respond to ICB, the mechanisms underlying these responses and the lack …

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Supplementary Figure 2 from Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRPM4

Makito Mizunuma, Christophe E. Redon, Liton Kumar Saha, Andy D. Tran et autres

Morphological changes in TRPM4-KO and chronic exposure (CE) cells.

Supplementary Figure 5 from Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRPM4

Makito Mizunuma, Christophe E. Redon, Liton Kumar Saha, Andy D. Tran et autres

TRPM4 RNA expression and categories of gene sets enriched in response to Acetalax treatment.

Supplementary Figure Legends 1-6 from Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRPM4

Makito Mizunuma, Christophe E. Redon, Liton Kumar Saha, Andy D. Tran et autres

Legends for the Supplementary figures.

Supplementary Figure 4 from Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRPM4

Makito Mizunuma, Christophe E. Redon, Liton Kumar Saha, Andy D. Tran et autres

Scatter plot of Acetalax activity versus TRPM4 transcript expression.

Supplementary Figure 1 from Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRPM4

Makito Mizunuma, Christophe E. Redon, Liton Kumar Saha, Andy D. Tran et autres

Bisacodyl structure, effect on TNBC cell lines and similarity to Acetalax.

Supplementary Figure 6 from Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRPM4

Makito Mizunuma, Christophe E. Redon, Liton Kumar Saha, Andy D. Tran et autres

Exogenous TRPM4 expression sensitizes TRPM4 negative and acetalax-resistant MDAMB231 and MDAMB436 cells to acetalax.

Supplementary Figure 3 from Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRPM4

Makito Mizunuma, Christophe E. Redon, Liton Kumar Saha, Andy D. Tran et autres

Mitochondrial morphological changes caused by Acetalax in BT549.

Mechanism for local attenuation of DNA replication at double-strand breaks

Robin Sebastian, Eric G. Sun, Michael Fedkenheuer, Haiqing Fu et autres

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