Bastien Rival

27 Toxicity of an Al₂O₃ nanoparticle and HCl mixture: inhalations in vivo versus in vitro at the air–liquid interface

M. Cherrière, Suzanne De Araujo, Myriam Oger, Christine Frédéric et autres

Abstract Combustion of composite solid propellants in rockets and missiles releases high concentrations of alumina nanoparticles (Al₂O₃ NPs) and gaseous hydrogen chloride (HCl), raising concerns about pulmonary toxicity from repeated inhalation, especially in military contexts. Advanced air–liquid interface (ALI) exposure systems offer …

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Delayed and non-linear systemic effects of mixed alumina nanoparticle and hydrogen chloride inhalation revealed by metabolomics

Noémie Chouan, Benjamin Métoyer, Bastien Rival, M. Cherrière et autres

Combustion of solid propellants releases alumina nanoparticles (Al₂O₃ NPs) and hydrogen chloride gas (HCl g ), raising concerns for exposed personnel. Conventional markers often lack sensitivity to detect subtle systemic effects that may precede overt toxicity. To address this gap, we combined …

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Many but not all pathogen-associated molecular patterns aggravate neurogenic heterotopic ossification after spinal cord injury

Selwin Gabriel Samuel, Hsu-Wen Tseng, Bastien Rival, Valérie Barbier et autres

BACKGROUND: Neurogenic heterotopic ossifications (NHOs) are heterotopic bones that develop in periarticular muscles after traumatic brain (TBI) and spinal cord injuries (SCI). The mechanisms leading to NHO are incompletely understood and the only effective treatment to-date remains surgical resection. We previously established …

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Additional file 1 of Many but not all pathogen-associated molecular patterns aggravate neurogenic heterotopic ossification after spinal cord injury

Selwin Gabriel Samuel, Hsu-Wen Tseng, Bastien Rival, Valérie Barbier et autres

Additional file 1.

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Additional file 1 of Many but not all pathogen-associated molecular patterns aggravate neurogenic heterotopic ossification after spinal cord injury

Selwin Gabriel Samuel, Hsu-Wen Tseng, Bastien Rival, Valérie Barbier et autres

Additional file 1.

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A semi-automated workflow to quantify γ-H2AX DNA damage in pulmonary cell models and lung tissue sections

M. Cherrière, Myriam Oger, Suzanne De Araujo, Farah Nasser et autres

The quantification of DNA double-strand breaks via γ-H2AX immunolabeling is a cornerstone of genotoxicity assessment, yet classical nucleus-based counting is frequently constrained by cell morphology, high confluence, and complex tissue architectures. To overcome these limitations, we developed and validated a semi-automated image …

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Beyond cytotoxicity: pollutant mixtures elicit unconventional epithelial-fibroblast signaling in a human lung air-liquid interface co-culture model

J. Fredoc-Louison, M. Cherrière, Bastien Rival, Suzanne De Araujo et autres

Introduction Combined exposures to airborne nanoparticles and acidic gases are plausible during industrial accidents and in military settings involving propellants. Aluminum oxide nanoparticles (Al 2 O 3 NPs), widely used in industry and present in propellant formulations, together with hydrogen chloride (HCl), …

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Interleukin-6 Does Not Contribute to Neurogenic Heterotopic Ossification Pathogenesis

Dorothée Girard, Hsu‐Wen Tseng, Bastien Rival, Valérie Barbier et autres

Neurogenic heterotopic ossifications (NHOs) are ectopic bones developing in periarticular muscles after severe central nervous system injuries such as spinal cord injuries (SCI) and traumatic brain injuries (TBI). The pathogenesis of NHO is still poorly understood, and the only effective therapy remains …

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Spinal cord injury dysregulates fibro-adipogenic progenitors miRNAs signaling to promote neurogenic heterotopic ossifications

Jules Gueguen, Dorothée Girard, Bastien Rival, Juliette Fernandez et autres

Neurogenic heterotopic ossifications are intramuscular bone formations developing following central nervous system injury. The pathophysiology is poorly understood and current treatments for this debilitating condition remain unsatisfying. Here we explored the role of miRNAs in a clinically relevant mouse model that combines …

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Bacterial Lipopolysaccharides Exacerbate Neurogenic Heterotopic Ossification Development

Marjorie Salga, Selwin Gabriel Samuel, Hsu-Wen Tseng, Laure Gatin et autres

ABSTRACT Neurogenic heterotopic ossifications (NHO) are heterotopic bones that develop in periarticular muscles after severe central nervous system (CNS) injuries. Several retrospective studies have shown that NHO prevalence is higher in patients who suffer concomitant infections. However, it is unclear whether these …

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Producing vesicle-free cell culture additive for human cells extracellular vesicles manufacturing

Bileyle Lorenzini, Juliette Peltzer, Sylvie Goulinet, Bastien Rival et autres

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Production and use of extracellular vesicles-depleted human platelet lysate to improve large, clinical grade-compatible production of therapeutic human cell-derived extracellular vesicles

Juliette Peltzer, Sylvie Goulinet, Bileyle Lorenzini, Bastien Rival et autres

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