Yao Shen

Key challenges in communication across milestones of cancer care continuum: a systematic review

Viet Cuong Nguyen, Khoa Tran, Do-Quyen Thi Phan, Nguyen-Tuong Pham et autres

BACKGROUND: Effective communication is essential in cancer care, significantly influencing patients' emotional, psychological, and physical outcomes. As patients' needs and goals evolve across different stages of the cancer journey, communication barriers also change. This systematic review aimed to identify key communication barriers …

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Fibronectin 1 mediates pressure-induced aggressive phenotypes in colorectal cancer cells and cancer stem cells

Viet Cuong Nguyen, Kuang-Chao Cheng, Thuy-Tien Thi Phan, Thi-Luu Ho et autres

BACKGROUND: Multiple interacting factors within the tumor microenvironment, including mechanical pressure, extracellular matrix components, hypoxia, and vascular architecture, are known to promote cancer progression. Although fibronectin 1 functions as a critical extracellular matrix glycoprotein in colorectal cancer, its specific interaction with mechanical …

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Sclerofish A and B: Two Pairs of Enantiomeric Diterpenoids Featuring a 4/7/6-Fused Tricyclic Scaffold from the Soft Coral Sclerophytum humesi

Phuong Vu Luu, Thuy-Tien Thi Phan, Quoc-Dung Tran Huynh, Ngoc-Thac Pham et autres

High Resolution Image Download MS PowerPoint Slide Two pairs of enantiomeric diterpenoids, (±)-sclerofish A ( 1 ) and (±)-sclerofish B ( 2 ), featuring a rare 4/7/6-fused tricyclic framework, were isolated from the soft coral Sclerophytum humesi by molecular networking-guided isolation. Their …

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Critical radiosensitizing parameters of dual-modality gold nanodandelion against cancer radioresistance in MV X-ray and proton therapies

Yao Chen Chuang, Jeng‐Fong Chiou, Ping-Hsiu Wu, Yao Shen et autres

Gold-based nanomaterials have emerged as promising nanoradioenhancers (NREs), with growing experimental and clinical evidence supporting their efficacy in both photon and proton therapies. However, the underlying mechanisms of nanoparticle-induced radioenhancement in clinical radiotherapy remain unclear. Here, we investigate the NRE mechanisms of …

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Author response for "Targeting glutamine metabolism combined with nanoradioenhancer in radioresistant hepatocellular carcinoma"

Chia-Chun Kuo, Yao-Chen Chuang, Ping-Hsiu Wu, Wei-Min Chang et autres

Anticancer and Skin Anti-Inflammatory Triterpenoid Saponins from the Leaves of Miracle Fruit (Synsepalum dulcificum)

Quoc-Dung Tran Huynh, Shu-Man Hsieh Li, Thuy-Tien Thi Phan, Ta-Wei Liu et autres

Targeting glutamine metabolism combined with a nanoradioenhancer in radioresistant hepatocellular carcinoma

Chia‐Chun Kuo, Yao-Chen Chuang, Ping‐Hsiu Wu, Wei‐Min Chang et autres

CI = 0.462). These findings indicate that RT/GNDs@gelatin/DON achieved strong synergism (CI < 0.3), whereas RT/DON exhibited only moderate synergy (0.3 < CI < 0.7). Mechanistically, this dual-functional strategy not only augmented DNA damage, but also triggered mitochondrial dysfunction, leading to greater …

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Sclerohumins G-L: Selective cytotoxic diterpenoids featuring a 4/9-fused ring system from the soft coral Sclerophytum humesi

Phuong Vu Luu, Thuy-Tien Thi Phan, Huong-Giang Le, Lo-Yun Chen et autres

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Unusual diterpenoids featuring a 4/9-fused ring system from Sclerophytum humesi trigger intrinsic apoptosis via caspase-dependent PARP cleavage in pancreatic cancer

Phuong Vu Luu, Bo‐Rong Peng, Thuy-Tien Thi Phan, Quoc-Dung Tran Huynh et autres

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High-efficiency engineering of cell membrane nanovesicles with intrinsic homotypic targeting for precision cancer drug delivery

Thi-Luu Ho, T. Phan, I-Lin Tsai, T Huynh et autres

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Neutrophils and neutrophil extracellular traps: double-edged swords in cancer pathophysiology and therapy resistance

Yao Shen, Huijie Fang, Huiqi Xie, Xiaoqi Wang et autres

Among white blood cells (WBCs), neutrophils are the most abundant and multifunctional immune cells in the blood, which are also involved in diverse physiological and pathological processes, particularly affecting the deterioration of the tumor. Neutrophil extracellular traps (NETs), composed of chromatin DNA …

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Hepatic lipidomics reveals lipid metabolism reprogramming response to different branched-chain amino acids interventions in nonalcoholic fatty liver disease of laying hens

Huafeng Jian, Fengcheng Miao, Yi Zheng, Zhiyu Li et autres

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