Cortney C. Winkle

Beyond the cytoskeleton: The emerging role of organelles and membrane remodeling in the regulation of axon collateral branches

Gianluca Gallo, Kendra L. Taylor, Karen F. Greif, Stephanie L. Gupton et autres

The generation of axon collateral branches is a fundamental aspect of the development of the nervous system and the response of axons to injury. Although much has been discovered about the signaling pathways and cytoskeletal dynamics underlying branching, additional aspects of the …

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A novel Netrin-1–sensitive mechanism promotes local SNARE-mediated exocytosis during axon branching

Charles S. Park, Leslie M. McClain, Christopher Maglione, Cortney C. Winkle et autres

Localized plasma membrane expansion during axon branching mediated by Netrin-1 occurs via TRIM9-dependent regulation of SNARE-mediated vesicle fusion.Developmental axon branching dramatically increases synaptic capacity and neuronal surface area. Netrin-1 promotes branching and synaptogenesis, but the mechanism by which Netrin-1 stimulates plasma membrane …

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The E3 Ubiquitin Ligase TRIM9 Is a Filopodia Off Switch Required for Netrin-Dependent Axon Guidance

Stephanie L. Gupton, Nicholas P. Boyer, Dharmendra Kumar Pandey, Shalini Menon et autres

Neuronal growth cone filopodia contain guidance receptors and contribute to axon guidance; however, the mechanism by which the guidance cue netrin increases filopodia density is unknown. Here, we demonstrate that TRIM9, an E3 ubiquitin ligase that localizes to filopodia tips and binds …

Trim9 Deletion Alters the Morphogenesis of Developing and Adult-Born Hippocampal Neurons and Impairs Spatial Learning and Memory

Hyojin Kim, Reid H. J. Olsen, Stephanie L. Gupton, Juan Song et autres

During hippocampal development, newly born neurons migrate to appropriate destinations, extend axons, and ramify dendritic arbors to establish functional circuitry. These developmental stages are recapitulated in the dentate gyrus of the adult hippocampus, where neurons are continuously generated and subsequently incorporate into …

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Utilizing Combined Methodologies to Define the Role of Plasma Membrane Delivery During Axon Branching and Neuronal Morphogenesis

Stephanie L. Gupton, Cortney C. Winkle, Christopher C. Hanlin

During neural development, growing axons extend to multiple synaptic partners by elaborating axonal branches. Axon branching is promoted by extracellular guidance cues like netrin-1 and results in dramatic increases to the surface area of the axonal plasma membrane. Netrin-1-dependent axon branching likely …

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Membrane Trafficking in Neuronal Development: Ins and Outs of Neural Connectivity

Stephanie L. Gupton, Cortney C. Winkle

During development, neurons progress through rapid yet stereotypical shape changes to achieve proper neuronal connectivity. This morphological progression requires carefully orchestrated plasma membrane expansion, insertion of membrane components including receptors for extracellular cues into the plasma membrane and removal and trafficking of …

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TRIM9-dependent ubiquitination of DCC constrains kinase signaling, exocytosis, and axon branching

Fabio Urbina, Cortney C. Winkle, Kristen D. Phend, Caroline Monkiewicz et autres

Extracellular netrin-1 and its receptor deleted in colorectal cancer (DCC) promote axon branching in developing cortical neurons. Netrin-dependent morphogenesis is preceded by multimerization of DCC, activation of FAK and Src family kinases, and increases in exocytic vesicle fusion, yet how these occurrences …

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TRIM9-dependent ubiquitination of DCC constrains kinase signaling, exocytosis, and axon branching

Melissa Plooster, Shalini Menon, Cortney C. Winkle, Fabio Urbina et autres

Extracellular netrin-1 and its receptor deleted in colorectal cancer (DCC) promote axon branching in developing cortical neurons. Netrin-dependent morphogenesis is preceded by multimerization of DCC, activation of FAK and Src family kinases, and increases in exocytic vesicle fusion, yet how these occurrences …

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TRIM9-dependent ubiquitination of DCC constrains kinase signaling, exocytosis, and axon branching

Melissa Plooster, Shalini Menon, Cortney C. Winkle, Fabio Urbina et autres

Abstract Extracellular netrin-1 and its receptor DCC promote axon branching in developing cortical neurons. Netrin-dependent morphogenesis is preceded by multimerization of DCC, activation of FAK and Src family kinases, and increases in exocytic vesicle fusion, yet how these occurrences are linked is …

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Trim9 Deletion Alters the Morphogenesis of Developing and Adult-Born Hippocampal Neurons and Impairs Spatial Learning and Memory

Cortney C. Winkle, Reid H. J. Olsen, Hyojin Kim, Sheryl S. Moy et autres

UNLABELLED: During hippocampal development, newly born neurons migrate to appropriate destinations, extend axons, and ramify dendritic arbors to establish functional circuitry. These developmental stages are recapitulated in the dentate gyrus of the adult hippocampus, where neurons are continuously generated and subsequently incorporate …

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Beyond the cytoskeleton: The emerging role of organelles and membrane remodeling in the regulation of axon collateral branches

Cortney C. Winkle, Kendra L. Taylor, Erik W. Dent, Gianluca Gallo et autres

The generation of axon collateral branches is a fundamental aspect of the development of the nervous system and the response of axons to injury. Although much has been discovered about the signaling pathways and cytoskeletal dynamics underlying branching, additional aspects of the …

us (code pays fourni par la source)

Utilizing Combined Methodologies to Define the Role of Plasma Membrane Delivery During Axon Branching and Neuronal Morphogenesis

Cortney C. Winkle, Christopher C. Hanlin, Stephanie L. Gupton

During neural development, growing axons extend to multiple synaptic partners by elaborating axonal branches. Axon branching is promoted by extracellular guidance cues like netrin-1 and results in dramatic increases to the surface area of the axonal plasma membrane. Netrin-1-dependent axon branching likely …

us (code pays fourni par la source)