Carolyn J. Hu

Cryo-EM structure of TGFBIp fibrils driven by a corneal dystrophy–linked mutation enables design of peptide inhibitors of aggregation

Yi Xiao Jiang, Łukasz Salwiński, Michael R. Sawaya, P. Ge et autres

Corneal dystrophy is a heterogeneous group of diseases which manifests clinically by progressive corneal opacity and diminishing visual acuity. A group of corneal dystrophies are linked to autosomal dominant mutations in transforming growth factor β-induced protein (TGFBIp) and characterized by extracellular amyloid-positive …

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Patient-Reported Outcomes of Concomitant Deltoid and/or Syndesmotic Reconstruction With Broström for Global Chronic Ankle Instability: The Role of Deltoid Stability

Steven M. Hadley, Eric H. Durudogan, Rachel F. Bergman, Sarah J. Westvold et autres

Background: Medial and syndesmotic instability are risk factors for failure to return to pre-injury activity following Broström. This investigation aims to understand the extent to which superficial deltoid reconstruction (DR) and/or syndesmotic reconstruction (SR) affect global ankle stability in patients with global …

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Augmented Broström and Improved Functional Outcomes as Measured by PROMIS Scores Compared With Broström Without Augmentation

Steven M. Hadley, Rachel F. Bergman, Sarah J. Westvold, Tanya Kukreja et autres

Background: No study has compared functional outcomes measured by validated Patient-Reported Outcomes Measurement Information System (PROMIS) measures of physical function (PF) and pain interference (PI) between augmented and nonaugmented Broström procedures. Purpose: To determine whether the augmented Broström procedure is associated with …

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Patient-Reported Outcomes of Concomitant Deltoid and/or Syndesmotic Repair in Patients Undergoing Broström for Chronic Ankle Instability

Rachel F. Bergman, Steven M. Hadley, Sarah Westvold, Eric H. Durudogan et autres

Category: Ankle, Sports Keywords: Broström, Syndesmotic Injury, Deltoid Ligament Injury Introduction/Purpose: Prior literature suggests that concurrent medial and syndesmotic instability are risk factors for higher rates of postoperative dissatisfaction and failure to return to pre-injury activity. However, few studies have evaluated patient-reported …

Outcomes of augmented versus non-augmented broström for lateral ankle instability in the setting of ankle deformity

Steven M. Hadley, Rachel F. Bergman, Sarah J. Westvold, Tanya Kukreja et autres

BACKGROUND: It is unclear whether Broström with InternalBrace™ augmentation enables patients with structural cavovarus deformity to achieve satisfactory patient-reported outcomes. Patient Reported Outcomes Measurement Information System (PROMIS) measures of physical function (PF) and pain interference (PI) are validated metrics of orthopaedic foot …

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Fear of Reinjury Limits Patient Functional Outcomes as Measured by PROMIS Following Augmented Broström Procedure

Steven M. Hadley, Rachel F. Bergman, Sarah Westvold, Tanya Kukreja et autres

Research Type: Level 3 - Retrospective cohort study, Case-control study, Meta-analysis of Level 3 studies Introduction/Purpose: Prior evidence suggests that fear of reinjury may impact return to activity following Broström ligament repair; however, this study did not examine the role of fear …

Broström with InternalBrace Augmentation Significantly Improves Ankle Stability Measured by the Cumberland Ankle Instability Tool Compared to Broström Without Augmentation

Steven M. Hadley, Rachel F. Bergman, Sarah Westvold, Tanya Kukreja et autres

Research Type: Level 3 - Retrospective cohort study, Case-control study, Meta-analysis of Level 3 studies Introduction/Purpose: Limited data exist regarding whether primary Broström with InternalBraceTM augmentation bolsters ankle stability compared to Broström without augmentation. The Cumberland Ankle Instability Tool (CAIT) is a …

Augmented Broström Enables Patients with Anatomic Ankle Deformities to Achieve Population Mean Function and Pain as Measured by PROMIS

Steven M. Hadley, Rachel F. Bergman, Sarah Westvold, Tanya Kukreja et autres

Research Type: Level 3 - Retrospective cohort study, Case-control study, Meta-analysis of Level 3 studies Introduction/Purpose: The extent to which primary Broström with InternalBraceTM augmentation enables patients with deformities to achieve satisfactory patient-reported outcomes is unclear. Patient Reported Outcomes Measurement Information System …

Augmented Broström is Associated with Improved Functional Outcomes as Measured by PROMIS Scores Compared to Broström Without Augmentation

Steven M. Hadley, Rachel F. Bergman, Sarah Westvold, Tanya Kukreja et autres

Research Type: Level 3 - Retrospective cohort study, Case-control study, Meta-analysis of Level 3 studies Introduction/Purpose: It is unknown whether primary Broström with InternalBraceTM augmentation results in improved functional outcomes compared to primary Broström without augmentation for patients with chronic lateral ankle …

Fear of Reinjury Limits Patient Functional Outcomes as Measured by PROMIS Following Augmented Broström Procedure

Steven M. Hadley, Rachel F. Bergman, Sarah J. Westvold, Tanya Kukreja et autres

Background: Fear of reinjury (FORI) can hinder recovery in several orthopaedic conditions, but its impact after augmented Broström repair is unknown. We sought to determine the prevalence of FORI and its association with functional outcomes in this setting. This study aims to …

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Liganded magnetic nanoparticles for magnetic resonance imaging of α-synuclein

Hope Pan, Melinda Balbirnie, Ke Hou, Naomi S. Sta Maria et autres

Aggregation of the protein α-synuclein (α-syn) is the histopathological hallmark of neurodegenerative diseases such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), which are collectively known as synucleinopathies. Currently, patients with synucleinopathies are diagnosed by physical …

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Daily Heart Rate per Step: A Wearables Metric Associated With Cardiovascular Disease in a Cross‐Sectional Study of the All of Us Research Program

Zhanlin Chen, C. Wang, Carolyn J. Hu, Kendra M. Ward et autres

Background Simple biometrics such as peak heart rate and exercise duration remain core predictors of cardiovascular disease (CVD). Commercial wearable devices track physical and cardiac electrical activity. Detailed, longitudinal data collection from wearables presents a valuable opportunity to identify new factors associated …

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