Shari Wang

Rapid, HIF-1α-independent, response of VEGF secretion to decreased O 2 in mouse retina

Varun Kamat, Matthew K. Grumbine, Khang Bao, Lui Tsumura et autres

Vascular endothelial growth factor-A (VEGF) is a critical determinant of retinopathy due to vascular complications. Its expression is chronically regulated by transcription factors notably hypoxia-inducible factor-1α (HIF-1α) in response to decreased availability of oxygen [O 2 ]. We considered whether there is …

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Combined Prebiotic Dietary Inulin and VSL#3 Probiotics Modulate Gut Metabolites to Improve Energy Balance and Glucose Metabolism in Diet-Induced Obese Mice

Karolline S. May, Ángel Lee, Shari Wang, Robin Altman et autres

Objectives: Inulin, a prebiotic dietary fiber, reduces body weight gain and improves glucose metabolism in obese mice. In the current study, we sought to determine whether combining inulin supplementation with VSL#3, a probiotic blend, could further improve energy balance and glucose metabolism …

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Abstract 4135662: Dietary Inulin Improves Glucose Metabolism and Energy Balance in Obese Mice via Adipocyte Free Fatty Acid Receptor 2 (FFAR2)

Karolline S. May, Ángel Lee, Shari Wang, Caeley L. Bryan et autres

Background: Inulin is a non-digestible prebiotic dietary fiber that can promote metabolic health including reduced body weight and improved glucose metabolism via effects on gut microbiota. We hypothesize that inulin prevents obesity-associated cardiometabolic alterations by augmenting the production of short-chain fatty acids …

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The role of intestinal microbiota in physiologic and body compositional changes that accompany CLA-mediated weight loss in obese mice

Meifan Zhang, Yue S Yin, Karolline S. May, Shari Wang et autres

OBJECTIVE: Obesity continues to be a major problem, despite known treatment strategies such as lifestyle modifications, pharmaceuticals, and surgical options, necessitating the development of novel weight loss approaches. The naturally occurring fatty acid, 10,12 conjugated linoleic acid (10,12 CLA), promotes weight loss …

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Adipocyte-Specific Deletion of Free Fatty Acid Receptor 2 (FFAR2) Worsens Energy Metabolism in Diet-Induced Obese Mice

Karolline S. May, Shari Wang, Caeley L. Bryan, Martin J. Blaser et autres

Objectives: The short-chain fatty acid (SCFA) acetate, produced by gut microbes, beneficially impacts host metabolism. Because acetate binds free-fatty acid receptor 2 (FFAR2), which is highly expressed on adipocytes, we hypothesized that increasing systemic acetate improves adipose tissue function and prevents obesity-related …

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sTREM2 is a plasma biomarker for human NASH and promotes hepatocyte lipid accumulation

Vishal M Kothari, Christopher E. Savard, Jingjing Tang, Sum P. Lee et autres

BACKGROUND: Pathogenetic mechanisms of the progression of NAFL to advanced NASH coupled with potential noninvasive biomarkers and novel therapeutic targets are active areas of investigation. The recent finding that increased plasma levels of a protein shed by myeloid cells -soluble Triggering Receptor …

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Aging Increases Susceptibility to Develop Cardiac Hypertrophy following High Sugar Consumption

Ana P. Valencia, Jeremy D. Whitson, Shari Wang, Leon T. Nguyen et autres

Aging and poor diet are independent risk factors for heart disease, but the impact of high-sucrose (HS) consumption in the aging heart is understudied. Aging leads to impairments in mitochondrial function that result in muscle dysfunction (e.g., cardiac remodeling and sarcopenia). We …

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10,12-Conjugated linoleic acid supplementation improves HDL composition and function in mice

Tomáš Vaisar, Shari Wang, Mohamed Omer, Angela D. Irwin et autres

Obesity is associated with inflammation, insulin resistance, and type 2 diabetes, which are major risk factors for CVD. One dietary component of ruminant animal foods, 10,12-conjugated linoleic acid (10,12 CLA), has been shown to promote weight loss in humans. Previous work has …

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Comparison between genetic and pharmaceutical disruption of Ldlr expression for the development of atherosclerosis

Diego Juvenal Gomes, Shari Wang, Leela Goodspeed, Katherine E. Turk et autres

Antisense oligonucleotides (ASOs) against Ldl receptor (Ldlr-ASO) represent a promising strategy to promote hypercholesterolemic atherosclerosis in animal models without the need for complex breeding strategies. Here, we sought to characterize and contrast atherosclerosis in mice given Ldlr-ASO with those bearing genetic Ldlr …

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Sexually Dimorphic Relationships Among Saa3 (Serum Amyloid A3), Inflammation, and Cholesterol Metabolism Modulate Atherosclerosis in Mice

Alan Chait, Shari Wang, Leela Goodspeed, Diego Juvenal Gomes et autres

Objective: Expression of the extrahepatic acute-phase protein Saa3 (serum amyloid A3) increases in response to acute and chronic inflammatory stimuli and is elevated in adipose tissue and macrophages in obese mice. A recent report suggested that Saa3 is proatherogenic in male ApoE …

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Serum amyloid A–containing HDL binds adipocyte-derived versican and macrophage-derived biglycan, reducing its antiinflammatory properties

Chang Yeop Han, Inkyung Kang, Mohamed A. Omer, Shari Wang et autres

The ability of HDL to inhibit inflammation in adipocytes and adipose tissue is reduced when HDL contains serum amyloid A (SAA) that is trapped by proteoglycans at the adipocyte surface. Because we recently found that the major extracellular matrix proteoglycan produced by …

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Glycation of HDL blunts its anti-inflammatory and cholesterol efflux capacities in vitro, but has no effect in poorly controlled type 1 diabetes subjects

Diego Gomes Kjerulf, Shari Wang, Mohamed A. Omer, Asha Pathak et autres

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