Accès ouvert
2026
preprint
OpenAlex
Alyssa F. Pybus, Junhao Qiu, Paulo C. Lyra, Khai Dang et autres
Abstract Survival analysis is a fundamental technique in biomedical research for modeling time-to-event data. It enables the identification of prognostic factors in disease, compares survival outcomes across treatment groups, and performs targeted treatment selection. A variety of machine learning (ML) approaches to …
us
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Alyssa F. Pybus, Isis Yanina Narvaez-Bandera, Tosin Jolaogun, Paulo C. Lyra et autres
Abstract Background: While immune checkpoint blockade (ICB) therapy can produce durable clinical responses and substantially improve patient outcomes, accurate predictors of outcomes are critical as up to half of patients with advanced disease derive limited or no benefit. Accurate ICB outcome prediction …
us
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Paulo C. Lyra, Junhao Qiu, Khai Dang, Alyssa F. Pybus et autres
Abstract Machine learning (ML) has revolutionized biomedical research, enabling accurate prediction from large and often high-dimensional datasets through statistical modeling and pattern recognition. Examples of ML applications include predicting patient responses to cancer therapies and classifying cancer lesions. However, the lack of …
us
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Isis Yanina Narvaez-Bandera, Alyssa F. Pybus, Tosin Jolaogun, P. C. Lyra et autres
Abstract Immune checkpoint blockade (ICB) has revolutionized cancer therapy, yet many patients derive limited benefit or experience adverse effects. Thus, it becomes crucial to identify when a patient is likely to respond well to ICB treatment, thereby guiding treatment decisions and improving …
us
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Alyssa F. Pybus, Raphael Kirchgaessner, Mr Jonathan Nguyen, Carlos Moran Segura et autres
There is an acute need to accurately identify patients with advanced melanoma who are most likely to respond to anti-PD1 immune checkpoint blockade (ICB) therapy. While anti-PD1 therapy can be highly effective in advanced melanoma patients, only 30-40% of patients respond well. …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Sara Bitarafan, Alyssa F. Pybus, Felix G. Rivera Moctezuma, Mohammad Adibi et autres
Current clinical trials are investigating gamma frequency sensory stimulation as a potential therapeutic strategy for Alzheimer's disease (AD); yet, we lack a comprehensive picture of the effects of this stimulation on multiple aspects of brain function. We previously showed that exposing mice …
us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
J. Fang, Saravanan Ayyadurai, Alyssa F. Pybus, Hiroshi Sugimoto et autres
Fabry disease, an X-linked lysosomal storage disorder caused by galactosidase α (GLA) gene mutations, exhibits diverse clinical manifestations, and poses significant diagnostic challenges. Early diagnosis and treatment are crucial for improved patient outcomes, pressing the need for reliable biomarkers. In this study, …
us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Alyssa F. Pybus, Sara Bitarafan, Rowan O. Brothers, Alivia Rohrer et autres
Repetitive mild traumatic brain injuries (rmTBI) sustained within a window of vulnerability can result in long term cognitive deficits, depression, and eventual neurodegeneration associated with tau pathology, amyloid beta (Aβ) plaques, gliosis, and neuronal and functional loss. However, a comprehensive study relating …
us
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Sara Bitarafan, Alyssa F. Pybus, Felix G. Rivera Moctezuma, Mohammad Adibi et autres
Background: Current clinical trials are investigating gamma frequency sensory stimulation as a potential therapeutic strategy for Alzheimer's disease, yet we lack a comprehensive picture of the effects of this stimulation on multiple aspects of brain function. While most prior research has focused …
us
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
J. Fang, Saravanan Ayyadurai, Alyssa F. Pybus, Hiroshi Sugimoto et autres
Abstract Fabry disease, an X-linked lysosomal storage disorder caused by galactosidase alpha (GLA) gene mutations, exhibits diverse clinical manifestations, and poses significant diagnostic challenges. Early diagnosis and treatment are crucial for improved patient outcomes, pressing the need for reliable biomarkers. In this …
jp
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Katie L. Bales, Austin M. Karesh, Kelleigh Hogan, Alicia S. Chacko et autres
Whole-body physical exercise has been shown to promote retinal structure and function preservation in animal models of retinal degeneration. It is currently unknown how exercise modulates retinal inflammatory responses. In this study, we investigated cytokine alterations associated with retinal neuroprotection induced by …
us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Alexis N. Pulliam, Alyssa F. Pybus, David A. Gaul, Samuel G. Moore et autres
Traumatic brain injury (TBI) is a significant source of disability in the United States and around the world and may lead to long-lasting cognitive deficits and a decreased quality of life for patients across injury severities. Following the primary injury phase, TBI …
us
(code pays fourni par la source)