Eliška Miková

A centrally positioned cluster of multiple centrioles in antigen-presenting cells fosters T cell activation

Isabel Stötzel, Ann-Kathrin Weier, Apurba Sarkar, Subhendu Som et autres

Cellular polarization plays a crucial role in regulating immunological processes and is often associated with reorientation of the centrosome. During immune synapse formation, centrosome repositioning in lymphocytes assists in T cell activation. While a single centrosome, consisting of two centrioles, is present …

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The Ability of Probiotic Strain Escherichia coli O83:K24:H31 to Modulate Gut Homeostasis and Immune Function After Antibiotic-Induced Dysbiosis

Eliška Miková, Eliška Krčmářová, Viktor Černý, Lydie Sklenářová et autres

A healthy microbiome and a homeostatic interaction between the microbiome and the host immune system are essential for proper nutrition and overall health. Excessive use of antibiotics (ATB) can disrupt the healthy gut microenvironment, leading to dysbiosis, a condition linked to a …

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The ability of probiotic strain Escherichia coli O83:K24:H31 to modulate gut homeostasis and immune function after antibiotic-induced dysbiosis

Eliška Miková, Eliška Krčmářová, Viktor Černý, Lydie Sklenářová et autres

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Multiple clustered centrosomes in antigen-presenting cells foster T cell activation without MTOC polarization

Isabel Stötzel, Ann-Kathrin Weier, Apurba Sarkar, Subhendu Som et autres

Abstract Cellular polarization plays a pivotal role in regulating immunological processes and is often associated with centrosome reorientation. During immune synapse (IS) formation centrosome repositioning in lymphocytes assists in T cell activation. While a single centrosome, consisting of two centrioles, is present …

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Immature neutrophils in cord blood exert increased expression of genes associated with antimicrobial function

Eliška Miková, Viktor Černý, Olga Novotná, Petra Petrásková et autres

Introduction: The immune systems of both the mother and the newborn face significant challenges during birth. Proper immune regulation after birth is essential for the survival of neonates. Numerous studies have demonstrated that the neonatal immune system is relatively immature, particularly in …

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Czech Young Immunologists: Bound by science, united in purpose

Sabina Vancikova, Iva Benešová, Viktor Černý, Petra Lázničková et autres

The history of Czech immunology features excellent scientists who contributed to the comprehension of the immune system despite the restrictions by the communist regime, such as Milan Hasek (immunological tolerance) [1], Jan Klein (immunogenetics) [2], Jaroslav Sterzl (gnotobiology) [3], and others. At …

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Author response for "Czech Young Immunologists: Bound by Science, United in Purpose"

Sabina Vancikova, Iva Benešová, Viktor Černý, Petra Lázničková et autres

Multiple centrosomes enhance migration and immune cell effector functions of mature dendritic cells

Ann-Kathrin Weier, Mirka Homrich, Stephanie Ebbinghaus, Pavel Jůda et autres

Centrosomes play a crucial role during immune cell interactions and initiation of the immune response. In proliferating cells, centrosome numbers are tightly controlled and generally limited to one in G1 and two prior to mitosis. Defects in regulating centrosome numbers have been …

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