Nadine Keller

Structure and biosynthesis of deoxy-polyamine in Xenorhabdus bovienii

Sebastian L. Wenski, Natalie Berghaus, Nadine Keller, Helge B. Bode

Polyamine moieties have been described as part of the fabclavine and zeamine family of natural products. While the corresponding biosynthetic gene clusters have been found in many different proteobacteria, a unique BGC was identified in the entomopathogenic bacterium Xenorhabdus bovienii. Mass spectrometric …

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Rücktitelbild: Promoter Activation in Δhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing (Angew. Chem. 52/2019)

Edna Bode, Antje K. Heinrich, Merle Hirschmann, Desalegne Abebew et autres

Die gezielte Aktivierung von Biosynthesegenclustern in Δhfq-Mutanten verschiedener Proteobakterien vereinfacht die Isolierung und biologische Testung der dadurch exklusiv produzierten Naturstoffe, wie E. Bode et al. in ihrem Forschungsartikel auf S. 19133 zeigen. easyPACId (“Easy promoter activated compound identification”) aktiviert auch stille Gencluster, …

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Back Cover: Promoter Activation in Δhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing (Angew. Chem. Int. Ed. 52/2019)

Edna Bode, Antje K. Heinrich, Merle Hirschmann, Desalegne Abebew et autres

Selective activation of biosynthetic gene clusters in Δhfq strains of different proteobacteria facilitates isolation and bioactivity testing of (exclusively produced) natural products as described by H. B. Bode et al. in their Research Article on page 18957. Easy Promoter Activated Compound Identification …

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Promoter Activation in Δhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing

Edna Bode, Antje K. Heinrich, Merle Hirschmann, Desalegne Abebew et autres

Natural products (NPs) from microorganisms have been important sources for discovering new therapeutic and chemical entities. While their corresponding biosynthetic gene clusters (BGCs) can be easily identified by gene-sequence-similarity-based bioinformatics strategies, the actual access to these NPs for structure elucidation and bioactivity …

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Promoter Activation in Δhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing

Edna Bode, Antje K. Heinrich, Merle Hirschmann, Desalegne Abebew et autres

Abstract Natural products (NPs) from microorganisms have been important sources for discovering new therapeutic and chemical entities. While their corresponding biosynthetic gene clusters (BGCs) can be easily identified by gene‐sequence‐similarity‐based bioinformatics strategies, the actual access to these NPs for structure elucidation and …

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Improved cellulase expression in diploid yeast strains enhanced consolidated bioprocessing of pretreated corn residues

Steffi A. Davison, Nadine Keller, Willem Heber van Zyl, Riaan den Haan

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