Accès ouvert
2026
article
OpenAlex
Rashmi Gupta, Breven S. Simcox, Kyle H. Rohde
ABSTRACT Mycobacterium abscessus ( Mab ) is a multidrug-resistant nontuberculous mycobacterium that causes debilitating tuberculosis (TB)-like pulmonary infections for which effective treatment options are lacking. One contributing factor to the poor in vivo efficacy of antibiotics may be the altered vulnerability of …
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Accès ouvert
2025
preprint
OpenAlex
Rashmi Gupta, Breven S. Simcox, Kyle H. Rohde
ABSTRACT Mycobacterium abscessus ( Mab ) is a multidrug-resistant nontuberculous mycobacterium that causes debilitating TB-like pulmonary infections for which effective treatment options are lacking. Poor in vivo drug efficacy may stem from altered vulnerability of drug targets driven by host-specific environmental conditions. …
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Accès ouvert
2024
article
OpenAlex
Breven S. Simcox, Kyle H. Rohde
Mycobacterium abscessus (Mab) is an opportunistic pathogen afflicting individuals with underlying lung disease such as Cystic Fibrosis (CF) or immunodeficiencies. Current treatment strategies for Mab infections are limited by its inherent antibiotic resistance and limited drug access to Mab in its in …
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Accès ouvert
2023
article
OpenAlex
Breven S. Simcox, Brooke R. Tomlinson, Lindsey N. Shaw, Kyle H. Rohde
Mycobacterium abscessus (Mab), an emerging opportunistic pathogen, predominantly infects individuals with underlying pulmonary diseases such as cystic fibrosis (CF). Current treatment outcomes for Mab infections are poor due to Mab’s inherent antibiotic resistance and unique host interactions that promote phenotypic tolerance and …
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2021
article
OpenAlex
Rashmi Gupta, Noora Mohammed S.A Al-Kharji, Maha A. Alqurafi, Thu Quynh Nguyen et autres
High Resolution Image Download MS PowerPoint Slide Commercial carbapenem antibiotics are being used to treat multidrug resistant (MDR) and extensively drug resistant (XDR) tuberculosis. Like other β-lactams, carbapenems are irreversible inhibitors of serine d,d -transpeptidases involved in peptidoglycan biosynthesis. In addition to …
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