Ana Martínez‐Feito

Effectiveness and retention of certolizumab pegol and JAK inhibitors in rheumatoid arthritis: a multicenter retrospective study stratified by rheumatoid factor status

Mitndbaim Parra-Moreno, Lourdes Ladehesa-Pineda, J. Calvo-Gutiérrez, Francisco José Cepas-Guitérrez et autres

Background Patients with rheumatoid arthritis (RA) and high levels of Rheumatoid Factor (RF) often present with a higher inflammatory burden and may show a reduced response to JAK inhibitors (JAKi). However, previous studies have demonstrated that certolizumab pegol (CZP) provides comparable efficacy …

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Pharmacogenetic biomarkers for predicting therapeutic response to JAK inhibitors in rheumatoid arthritis

Chamaida Plasencia-Rodríguez, Marta Novella-Navarro, Juan Luis Valdivieso Shephard, Ana Martínez‐Feito et autres

Abstract Objectives Rheumatoid arthritis (RA) is a chronic inflammatory disease of immune-mediated origin. Janus kinase inhibitors (JAK inhibitors) have expanded therapeutic options in recent years; however, clinical response varies among patients, and no biomarkers are currently available to predict their efficacy. The …

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Impact of lymphocyte transformation test on the diagnostic accuracy of the culprit drug in drug-induced cytopenias: a case-control study

Susana Martín-López, Olga P. Rogozina, Daniela Aguilar-Concepción, Miguel Álvarez-Montero et autres

Background Drug-induced cytopenias are serious adverse drug reactions (ADRs), often challenging to diagnose. While causality algorithms offer high sensitivity and positive predictive values, they exhibit low specificity and negative predictive values for identifying the causative drug(s). Therefore, complementary diagnostic tools are required. …

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The Role of the Lymphocyte Transformation Test in Immune-Related Adverse Events from Immune Checkpoint Inhibitors: A Case Series

Fiorela C. Dueñas Lopez, Zoraida del Solar Moreno, Daniela Aguilar-Concepción, Carmen Ruiz-Fernández et autres

Background: Immune-related adverse events (irAEs) represent a considerable complication associated with the use of immune checkpoint inhibitors (ICIs) in oncology patients. Assessing causality is particularly challenging in patients administered multiple therapeutic agents. The Lymphocyte Transformation Test (LTT) may aid in causality analysis, …

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Immunological Monitoring During Anti-CD20 Therapies to Predict Infection Risk and Treatment Response in Multiple Sclerosis Patients

Gabriel Torres Iglesias, Ana Martínez‐Feito, Laura Otero‐Ortega, MariPaz López-Molina et autres

BACKGROUND: Immunological monitoring in multiple sclerosis (MS) patients treated with disease-modifying drugs may help predict infectious complications and guide treatment. The main objective of this study was to evaluate whether anti-CD20 treatments in MS patients induce immunodeficiency and whether certain immunological parameters …

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Diagnostic performance of lymphocyte transformation test and flow cytometry in the identification of culprit drugs in organ-specific serious adverse drug reactions

Carmen Ruiz-Fernández, Ibtissam Akatbach-Bousaid, Olga P. Rogozina, Susana Martín-López et autres

OBJECTIVES: tests. The lymphocyte transformation test (LTT) is widely used, but flow cytometry has been proposed as an alternative due to LTT's limitations. This study evaluated the diagnostic performance of LTT and CD69 upregulation on T lymphocytes by flow cytometry. METHODS: A …

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Immune monitoring and risk of infection in pediatric liver transplantation: a prospective study

Ricardo Cuesta‐Martín de la Cámara, Laura Miguel‐Berenguel, Carmen Cámara, Itsaso Losantos-García et autres

Background Immune monitoring has been proposed to optimize immunosuppressive therapy in liver recipients. This study aims to describe immunological changes following liver transplantation in pediatric recipients and to identify immune markers associated with post-transplant complications. Methods The immunological status of 95 pediatric …

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ABS0271 RELEVANCE OF THE PRESENCE AND TITERS OF AUTOANTIBODIES (RHEUMATOID FACTOR AND ANTIPROTEIN CITRULLINATED PEPTIDE) IN THE LEVELS OF NON-ANTI-TNF DRUGS IN PATIENTS WITH RHEUMATOID ARTHRITIS

Sonia Santamaria, M.C.V. Moreira, M. Novella-Navarro, P. Nozal Aranda et autres

Background: Autoantibodies are the primary mechanism of pathogenicity in Rheumatoid Arthritis (RA), however, the diagnostic and prognostic significance of many of them remains unknown, with the most studied being the Rheumatoid Factor (RF), which targets the constant region (Fc) of IgG [1]. …

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ABS1004 UNRAVELING THE INFLUENCE OF RHEUMATOID FACTOR ON RA TREATMENT SUCCESS

Maria Juárez, Sofía P. Salas, M.C.V. Moreira, Ana Martínez‐Feito et autres

Background: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterized by synovial inflammation and articular bone destruction. A hallmark of RA is the presence of autoantibodies, such as rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA). RF are autoantibodies that target …

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Exosomal Protein Biomarkers in Arthritis: Deciphering the Inflammatory Profiles of RA and OA

C. Gómez, Chamaida Plasencia‐Rodríguez, Marta Novella-Navarro, Ana Martínez‐Feito et autres

Background/Objectives: Rheumatoid arthritis (RA) and osteoarthritis (OA) are highly prevalent diseases and their pathophysiology, diagnosis and treatment continue to be challenging. The aim of this study was to characterize and differentiate the profiles of the serum extracellular vesicles (EVs) isolated from RA …

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Do Obesity and Adipose Tissue Cytokines Influence the Response to Janus Kinase Inhibitors in Rheumatoid Arthritis?

Marta Novella-Navarro, Ana Maria Van Den Rym, C. López-Pedrera, Ana Martínez‐Feito et autres

Background: Obesity is a frequent comorbidity in rheumatoid arthritis (RA). This condition may lead these patients to have poorer disease control and a worse response to some of the available treatments. Objectives: We aim to analyze the role of body mass index …

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20967. TRATAMIENTO DE LA ESCLEROSIS MÚLTIPLE CON OCRELIZUMAB Y RITUXIMAB: MONITORIZACIÓN INMUNOLÓGICA A LARGO PLAZO PARA EVALUAR EL RIESGO DE INFECCIONES Y LA RESPUESTA AL TRATAMIENTO

Gabriel Torres Iglesias, Ana Martínez‐Feito, Laura Otero‐Ortega, M. López Molina et autres