M. Howell

POS0373 PHASE 1 CLINICAL TRIAL EVALUATING THE PHARMACOKINETICS AND PHARMACODYNAMICS OF A NOVEL IL-17A AND BAFF DUAL ANTAGONIST IN SJOGREN’S SYNDROME

M. Howell, Kiran Nistala, P. Faghihi, Abid Sattar et autres

86O Serial monitoring of circulating tumor DNA (ctDNA) as a tumor-agnostic biomarker to inform clinical outcomes of patients receiving experimental cancer medicine

Kyrillus S. Shohdy, A. Ortega Franco, A. Saud, R. Abdeltawab et autres

Targeted sequencing of ctDNA is a promising biomarker to inform the prognosis of patients (pts) with advanced cancer and guide experimental therapeutics in the heterogenous setting of phase I trials. Serial monitoring provides an early indication of response to experimental therapeutics.

gb, Égypte (code pays fourni par la source)

O-22 The initial impact of a joint lung and enhanced supportive care clinic on patient outcomes at a cancer centre

Alexandra McDougall, Carles Escriu, M. Howell, Jonathan Heseltine et autres

Background Enhanced Supportive Care (ESC) promotes the earlier implementation of supportive care within cancer care (Bakitas, Tosteson, Li, et al. J Clin Oncol. 2015;33(13):1438–1445; Bandieri, Banchelli, Artioli, et al. BMJ Support Palliat Care. 2020;10(4):e32; Monnery, Benson, Griffiths, et al. Int J Palliat …

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1433P CNS efficacy of atezolizumab, bevacizumab, carboplatin and paclitaxel in patients with non-small cell lung cancer and actionable mutations

Michel P. Rathbone, Ciara O’Hagan, Atif J. Khan, T. Cook et autres

gb (code pays fourni par la source)

A Group-Based, Videoconference-Delivered Physical Activity Program for Cancer Survivors

Heather J. Leach, Mary E. Crisafio, M. Howell, Andrew Nicklawsky et autres

ABSTRACT Introduction/Purpose Virtually supervised, group-based exercise presents an innovative way to expand the reach of exercise-oncology programs and help cancer survivors increase physical activity (PA) and connect with other participants. This study examined the feasibility, acceptability, and preliminary effects of a group-based …

us (code pays fourni par la source)

A Group-based Videoconferencing Intervention To Increase Physical Activity, Fitness, And Group Cohesion In Cancer Survivors

Heather J. Leach, Mary E. Crisafio, M. Howell, Andrew Nicklawsky et autres

PURPOSE: Group-based videoconferencing presents a viable and innovative way to help cancer survivors increase physical activity (PA), improve fitness outcomes, and connect with other participants. This study examined the effects of a pilot intervention on PA, muscular endurance, and group cohesion. METHODS: …

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Beta-testing Of A Synchronous, Virtually-delivered Group-based Exercise Program For Cancer Survivors

Heather J. Leach, Mary E. Crisafio, M. Howell, Lydia M. Prien

PURPOSE: The COVID-19 pandemic forced many face-to-face exercise programs for cancer survivors to shut down or transition to online delivery. Supervision from a qualified instructor and social support from other participants are integral components for successful exercise program adherence, but it is …

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Acute High-Intensity Interval Exercise in Multiple Sclerosis with Mobility Disability

Mary Hidde, M. Howell, Alexa DeBord, Heather J. Leach

Dear Editor-in-Chief, High-intensity interval training (HIIT) to improve a variety of physiologic outcomes is growing in popularity among clinical populations. However, limited evidence exists for HIIT among individuals with multiple sclerosis with high mobility disability (1–3). Thus, we read the article by …

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An improved cleaning system to reduce microbial contamination of poultry transport crates in the United Kingdom

Robert J. Atterbury, Adriano M. Gigante, D.B. Tinker, M. Howell et autres

AIM: Following previous research on improving the cleaning of crates used to transport broiler chickens from the farm to the abattoir, a demonstration project was undertaken to investigate improvements in crate washing on a commercial scale. METHODS AND RESULTS: The soak tank …

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Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study

Dominic G. Rothwell, Mahmood Ayub, Natalie Cook, Fiona Thistlethwaite et autres

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Mutation pattern analysis reveals polygenic mini-drivers associated with relapse after surgery in lung adenocarcinoma

Laura Bennett, M. Howell, Danish Memon, Chris Smowton et autres

The genomic lesions found in malignant tumours exhibit a striking degree of heterogeneity. Many tumours lack a known driver mutation, and their genetic basis is unclear. By mapping the somatic mutations identified in primary lung adenocarcinomas onto an independent coexpression network derived …

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Truncation- and motif-based pan-cancer analysis reveals tumor-suppressing kinases

Andrew Hudson, Natalie L. Stephenson, Cynthia Li, Eleanor W. Trotter et autres

A major challenge in cancer genomics is identifying "driver" mutations from the many neutral "passenger" mutations within a given tumor. To identify driver mutations that would otherwise be lost within mutational noise, we filtered genomic data by motifs that are critical for …

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